ChemicalBook > CAS DataBase List > PENITREM A

PENITREM A

Product Name: PENITREM A
CAS No.: 12627-35-9
Chemical Name: PENITREM A
Synonyms: PENITREM A;TREMORTIN A;JDUWHZOLEDOQSR-JKPSMKLGSA-N;Penitrem A Nsc354845;Penitrem A, blocker of KCa1.1;PENITREM A, PENICILLIUM PAXILLI;Penitrem A from Penicillium paxilli;penitrem A from penicillium palitans;7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14b...;2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
CBNumber: CB4155421
Molecular Formula: C37H44ClNO6
Formula Weight: 634.2
MOL File: 12627-35-9.mol

Less

PENITREM A Property

Melting point:: 238°C
Density: 1.0241 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 6 mg/ml)
form: White solid.
pka: 13.22±0.70(Predicted)
color: Amorphous solid
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Less

Safety

Hazard Codes: T+,T
Risk Statements: 26/27/28
Safety Statements: 36/37/39-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: RY7535000
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 29349990
Toxicity: LD50 orl-mus: 10 mg/kg 41KEAL -,108,78

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H300Fatal if swallowed

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P3053
Product name: Penitrem A
Purity: ≥95% (HPLC and TLC)
Packaging: 1mg
Price: $350
Updated: 2025/07/31

Sigma-Aldrich

Product number: P3053
Product name: Penitrem A
Purity: ≥95% (HPLC and TLC)
Packaging: 5mg
Price: $1250
Updated: 2025/07/31

Cayman Chemical

Product number: 11347
Product name: Penitrem A
Purity: ≥98%
Packaging: 1mg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 11347
Product name: Penitrem A
Purity: ≥98%
Packaging: 5mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 11347
Product name: Penitrem A
Purity: ≥98%
Packaging: 10mg
Price: $284
Updated: 2024/03/01

Less

PENITREM A Chemical Properties,Usage,Production

Description

Penitrem A (12627-35-9) is a fungal mycotoxin that acts as a selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+?(BK, KCa1.1) channel (100% block at 10 nM).1?Displays brain neurotoxicity in rats along with dose-dependent convulsions and death.2?An important tool for studying the role of BK channels in vascular function which is effective in cellular, tissue and?in vivo?experiments.3?Inhibits BK channels in inside-out and cell-attached patches, whereas iberiotoxin (considered the gold standard BK channel blocker) does not.3?May be used to partially ablate Purkinje cells in immature rat cerebellum providing a model for neural stem cell transplantation studies.4

Chemical Properties

Solid

Occurrence

A series of closely related metabolites of Penicillium crustosum has recently been isolated and the components separated chromatographically. Penitrem A forms colourless crystals from EtOH.

Uses

Penitrem A has been used as Ca²⁺-Activated K⁺ (BK) channel blocker to study its effect on BK current in bag cell neurons.

Uses

Penitrem A is a tremorgenic mycotoxin isolated from Penicillium species. Penitrem A is a selective blocker of high-conductance Ca2+-activated potassium channels.

Definition

ChEBI: Penitrem A is an organooxygen compound and an organic heterotricyclic compound.

Biochem/physiol Actions

Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum.

Safety Profile

Poison by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Clí and NOx.

storage

-20°C

References

References/Citations:
(1) Knaus et al. (1994), Tremorgenic Indole Alkaloids Potently Inhibit Smooth Muscle High-Conductance Calcium-Activated Potassium Channels; Biochemistry, 33 5819
(2) Breton et al. (1998), Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study; Toxicon., 36 645
(3) Asano et al. (2012), Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function; J. Pharmacol. Exp.Ther., 342 453
(4) Lu et al. (2008), Toxin-produced Purkinje cell death: a model for neural stem cell transplantation studies; Brain Res. 1207 207

PENITREM A Preparation Products And Raw materials

Raw materials

Preparation Products

Less

PENITREM A Suppliers

China 75 Germany 3 India 1 Japan 1 Switzerland 3 United Kingdom 9 United States 19 Global 111

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4511
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Qingdao IniKem BioPharmaTech Co.,Ltd

Tel: 0532-58268780 18561687109;
Fax: -
Email: sales@inikem.com
Country: China
ProdList: 299
Advantage: 55

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10410
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-029-81024372 17792795018
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 9997
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
Country: CHINA
ProdList: 7974
Advantage: 58

Wuhan Dingxintong Pharmaceutical Co. , Ltd.

Tel: 15871722230
Fax: 2796190295
Email: 15871722230@163.com
Country: China
ProdList: 4686
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 11438
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4171
Advantage: 58

Hubei Qifei Pharmaceutical Chemical Co., Ltd

Tel: 027-59322506 18071128681
Fax: 027-59322506
Email: 1438082200@qq.com
Country: China
ProdList: 9921
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 29668
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Naturewill Biotechnology Co., Ltd.

Tel: 028-82632533 18113192475
Email: 3157321941@qq.com
Country: China
ProdList: 4993
Advantage: 58

Shanghai Saikerui Biotechnology Co. , Ltd.

Tel: 021-58000709 15900491054
Email: info@scrbio.com
Country: China
ProdList: 9881
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5002
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

BePure (Beijing) Biotechnology Co.

Tel: 58896805
Email: 7993601name@qq.com
Country: CHINA
ProdList: 6620
Advantage: 58

Shanghai Weiyite Biotechnology Co., Ltd

Tel: 15317051735
Email: zhaojing@wytsci.com
Country: China
ProdList: 9980
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Chengdu DeSiTe Biological Technology Co., Ltd

Tel: 17308096051
Email: 3001048290@qq.com
Country: China
ProdList: 6219
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Alomone Labs

Tel: 4008-168-068 13121892008
Email: info@alomone.com
Country: China
ProdList: 1241
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

BBI Solutions

Tel: +1 207-517-0284 13121892008
Email: BBIname@qq.com
Country: China
ProdList: 6048
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Nanjing Aoze Chemical Co., Ltd.

Tel: 15189842686
Email: 31735135@qq.com
Country: China
ProdList: 2881
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

Glacier Biotechnology (Shanghai) Co., Ltd

Tel: 18721971460
Country: CHINA
ProdList: 126
Advantage: 58

Qingdao Everest Technology & Trade Co., Ltd.

Tel: 13792478491
Country: CHINA
ProdList: 161
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Beijing Bai Ao Si Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: yangmei@bioneeds.net
Country: CHINA
ProdList: 6999
Advantage: 58

Shanghai Bosheng Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1310057982@qq.com
Country: CHINA
ProdList: 790
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6525
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

Beijing Chief-East Tech Co.,Ltd (Qwbio)

Tel: --
Fax: --
Email: info@qwbio.com
Country: China
ProdList: 6912
Advantage: 50

Beijing Sizhengbai Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: marketing@4abio.com
Country: CHINA
ProdList: 6401
Advantage: 58

Fujifilm Wako (Guangzhou) Trading Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 1409
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6646
Advantage: 58

12627-35-9, PENITREM ARelated Search:

Penicillin G potassium salt D-Penicillamine CYCLOPENT[B]INDOLE, 1,2,3,4-TETRAHYDRO-7-METHYL- 4-TERT-AMYLCYCLOHEXANOL TRANS-4-TERT-BUTYLCYCLOHEXANOL Dihydromyrcenol 4-tert-Butylcyclohexanol 5-Ethylindole (R)-(-)-Methyl glycidyl ether 4-Methylindole Ethylhexylglycerin TRANS-4-TERT-PENTYLCYCLOHEXANOL 2,5-Dimethylindole (+/-)-GEOSMIN (1R)-1-(3-CHLOROPHENYL)ETHANOL 1-Phenylcyclobutane-1-ol 1-CYCLOBUTYLETHANOL 2,4-DIMETHYL-1H-INDOLE

TREMORTIN A

Penitrem A from Penicillium paxilli

PENITREM A

PENITREM A, PENICILLIUM PAXILLI

penitrem A from penicillium palitans

Penitrem A Nsc354845

JDUWHZOLEDOQSR-JKPSMKLGSA-N

2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol

7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14b...

Penitrem A, blocker of KCa1.1

12627-35-9

C37H44ClNO6

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Monovalent Ion Channels

Potassium Channel Modulators

Ion Channels

Voltage-gated Ion Channels

antibiotic