ChemicalBook > CAS DataBase List > H-GLU(OBZL)-OTBU HCL

H-GLU(OBZL)-OTBU HCL

Product Name
H-GLU(OBZL)-OTBU HCL
CAS No.
105590-97-4
Chemical Name
H-GLU(OBZL)-OTBU HCL
Synonyms
H-Glu(OBzl)-OtBu;Glu(Obzl)OtBu.HCl;H-GLU(OBZL-OTBU HC;H-GLU(OBZL)-OTBU HCL;L-Glu(OBzl)-OtBu·HCl;H-L-GLU(BZL)-OTBU HCL;H-L-GLU(OBZL)-OTBU HCL;GLUTAMIC ACID(OBZL)-OTBU HCL;H-Glu(Obzl)-Otbu hydrochloride;H-GLU(OBZL)-OTBU HCL USP/EP/BP
CBNumber
CB4161628
Molecular Formula
C16H24ClNO4
Formula Weight
329.82
MOL File
105590-97-4.mol
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H-GLU(OBZL)-OTBU HCL Property

Melting point:
104-107°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO, Methanol
form 
Solid
color 
Off-White
InChI
InChI=1/C16H23NO4.ClH/c1-16(2,3)21-15(19)13(17)9-10-14(18)20-11-12-7-5-4-6-8-12;/h4-8,13H,9-11,17H2,1-3H3;1H/t13-;/s3
InChIKey
TWBZXIOAVCJDKR-PHCOUKOGNA-N
SMILES
C1(C=CC=CC=1)COC(=O)CC[C@H](N)C(=O)OC(C)(C)C.Cl |&1:12,r|
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Safety

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
G598185
Product name
H-Glu(obzl)-otbuHydrochloride
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
X8766
Product name
H-Glu(OBzl)-OtBuHCl
Packaging
10g
Price
$101
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0017611
Product name
(5-BENZYL-1-TERT-BUTYL-2-AMINOPENTANEDIOATE HYDROCHLORIDE
Purity
98.00%
Packaging
1G
Price
$139.65
Updated
2021/12/16
Activate Scientific
Product number
AS38878
Product name
(S)-5-Benzyl 1-tert-butyl 2-aminopentanedioate hydrochloride
Purity
97% ee
Packaging
25g
Price
$239
Updated
2021/12/16
Activate Scientific
Product number
AS38878
Product name
(S)-5-Benzyl 1-tert-butyl 2-aminopentanedioate hydrochloride
Purity
97% ee
Packaging
1g
Price
$22
Updated
2021/12/16
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H-GLU(OBZL)-OTBU HCL Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

L-Glutamic Acid 1-(1,1-Dimethylethyl) 5-(Phenylmethyl) Ester Hydrochloride, is a versatile building block in the peptide chemistry. It can be used in the synthesis of series of dynamic peptides.

Uses

H-Glu(obzl)-otbu HCl

Synthesis

540-88-5

1676-73-9

105590-97-4

The general procedure for the synthesis of (S)-5-benzyl 1-tert-butyl 2-aminoglutarate hydrochloride from tert-butyl acetate and L-glutamic acid 5-benzyl ester was as follows: L-glutamic acid 5-benzyl ester (75 g) was dissolved in 750 ml of tert-butyl acetate, and the temperature of the reaction system was maintained at a temperature of less than 5°C by cooling the system with ice water from an external source. 26 ml of perchloric acid was added dropwise slowly in this condition, and after completion of addition, the temperature of the reaction system was raised to 25°C. The reaction was monitored by TLC until complete conversion of L-glutamic acid 5-benzyl ester. After completion of the addition, the temperature of the reaction system was raised to 25°C and the reaction was monitored by TLC until complete conversion of L-glutamic acid 5-benzyl ester. After the reaction was completed, the pH of the reaction solution was adjusted to 7-8 with aqueous sodium carbonate, and the aqueous and organic layers were separated. The organic layer was washed sequentially with water and brine and subsequently dried with anhydrous sodium sulfate. After filtration to remove the desiccant, tert-butyl acetate was removed by vacuum distillation at 50°C to obtain an oil. The oily substance was diluted with a small amount of ether and the pH was subsequently adjusted to 4-5 by addition of a pre-prepared ether hydrochloride solution, at which time the product precipitated. The precipitate was collected by filtration and dried to give 90 g of (S)-5-benzyl 1-tert-butyl 2-aminopentanedioate hydrochloride with a purity of 98.5% and a final yield of 80%.

References

[1] Patent: CN105541649, 2016, A. Location in patent: Paragraph 0014

H-GLU(OBZL)-OTBU HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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H-GLU(OBZL)-OTBU HCL Suppliers

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View Lastest Price from H-GLU(OBZL)-OTBU HCL manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-Glu(Obzl)-Otbu.HCl 105590-97-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-26
Career Henan Chemical Co
Product
H-GLU(OBZL)-OTBU HCL 105590-97-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-22

105590-97-4, H-GLU(OBZL)-OTBU HCLRelated Search:

gamma-Benzyl L-glutamate Diethyl L-glutamate hydrochloride H-GLU(OET)-OH H-GLU(OALL)-OALL P-TOSYLATE H-GLU(OBZL)-OBZL HCL synthesis-021-HCl L-Glutamic acid 5-cyclohexyl ester L-Glutamic acid dibenzyl ester 4-toluenesulfonate H-Gln(Trt)-OH.H2O H-Glu(Gly-him)-OH ETHYL 4-AMINOBUTYRATE HYDROCHLORIDE L-Norvaline ethyl ester hydrochloride Glycine tert butyl ester hydrochloride L-Alanine Isopropyl Ester Hydrochloride L-(+)-Glutamic acid hydrochloride H-Glu-OMe H-GLY-OIPR HCL H-NVA-OME HCL

  • H-GLU(OBZL)-OTBU HCL
  • H-L-GLU(BZL)-OTBU HCL
  • H-L-GLU(OBZL)-OTBU HCL
  • L-GLUTAMIC ACID ALPHA-T-BUTYL-DELTA-BENZYL DIESTER HYDROCHLORIDE
  • L-GLUTAMIC ACID ALPHA-T-BUTYL-GAMMA-BENZYL-DIESTER HYDROCHLORIDE
  • L-GLUTAMIC ACID GAMMA-BENZYL ESTER ALPHA-T-BUTYL ESTER
  • GLUTAMIC ACID(OBZL)-OTBU HCL
  • 5-benzyl 1-tert-butyl (2S)-2-aminopentanedioate hydrochloride
  • GLUTAMIC ACID ALPHA-TERT-BUTYL-GAMMA-BENZYL DIESTER HYDROCHLORIDE
  • L-Glutamicacidγ-benzylesterα-tert·butylesterhydrochloride
  • H-Glu(Obzl)-Otbu hydrochloride
  • L-Glutamic acid alpha-t-butyl-gamma-benzyl ester hydrochloride
  • L-GLUTAMIC ACID-A-T-BUTYL-Y-BENZYL DIESTER HYDROCHLORIDE
  • L-GLUTAMIC ACID-.GAMMA.-BENZYLESTER .ALPHA.-TERT-BUTYLESTER HYDROCHLORIDE
  • L-Glutamicacid-benzylestera-tertutylesterhydrochloride
  • (S)-5-benzyl 1-tert-butyl 2-aminopentanedioate hydrochloride
  • L-Glutamic acid γ-benzyl ester α-tert·butyl est
  • Glu(Obzl)OtBu.HCl
  • H-Glu(OBzl)-OtBu·HCl L-GlutaMicacidγ-benzylesterα-tert·butylesterhydrochloride
  • H-L-Glu(Bzl)-OtBu Hydrochloride
  • L-Glu(OBzl)-OtBu·HCl
  • L-Glutamic acid γ-benzyl ester α-tert-butyl ester hydrochloride≥ 99% (HPLC)
  • 5-O-benzyl 1-O-tert-butyl (2S)-2-aminopentanedioate,hydrochloride
  • H-GLU(OBZL-OTBU HC
  • L-GlutaMic acid, 1-(1,1-diMethylethyl) 5-(phenylMethyl) ester, hydrochloride
  • hydrochloride of α-tert-butyl-γ-benzyl L-glutaMate
  • L-GlutaMic acid,1-(1,1-diMethylethyl) 5-(phenylMethyl) ester, hydrochloride (1:1)
  • L-Gluotbu-5-(phenylmethyl) ester hydrochloride
  • H-Glu(OBzl)-OtBu
  • H-GLU(OBZL)-OTBU HCL USP/EP/BP
  • L-Glutamic acid γ-benzyl ester α-tert-butyl ester hydrochloride
  • 5-O-benzyl 1-O-tert-butyl (2S)-2-aminopentanedioate
  • L-Glutamic Acid 5-Benzyl 1-tert-Butyl Ester Hydrochloride
  • L-Glutamic acid γ-benzyl ester α-tert-butyl ester hydrochloride, >98%
  • L-Glutamic acid γ-benzyl ester α-tert·butyl est
  • (S)-5-Benzyl 1-tert-butyl 2-aminopentanedioate HCl
  • 105590-97-4
  • 626-64-1
  • C16H24ClNO4