AMINOPURVALANOL A

Product Name: AMINOPURVALANOL A
CAS No.: 220792-57-4
Chemical Name: AMINOPURVALANOL A
Synonyms: NG-97;AMINOPURVALANOL A;AMINOPURVALANOL A (APURV);(R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol;(2R)-2-[[6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL;1-Butanol, 2-[[6-[(3-amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-;inhibit,actin polymerization,Inhibitor,Cyclins,cancer cell differention,G2/M-phase transition,Apoptosis,Aminopurvalanol A,Cyclin dependent kinase,CDK,sperm fertilizing ability
CBNumber: CB4164371
Molecular Formula: C19H26ClN7O
Formula Weight: 403.91
MOL File: 220792-57-4.mol

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AMINOPURVALANOL A Property

Boiling point:: 639.0±65.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: Soluble to 100 mM in DMSO
form: White to brownish solid.
pka: 14.51±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21424
Product name: Aminopurvalanol A
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21424
Product name: Aminopurvalanol A
Purity: ≥98%
Packaging: 5mg
Price: $179
Updated: 2024/03/01

Tocris

Product number: 2072
Product name: AminopurvalanolA
Purity: ≥98%(HPLC)
Packaging: 10
Price: $225
Updated: 2021/12/16

Tocris

Product number: 2072
Product name: AminopurvalanolA
Purity: ≥98%(HPLC)
Packaging: 50
Price: $806
Updated: 2021/12/16

TRC

Product number: A628903
Product name: AminopurvalanolA
Packaging: 2.5mg
Price: $90
Updated: 2021/12/16

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AMINOPURVALANOL A Chemical Properties,Usage,Production

Uses

Aminopurvalanol A is a reversible and ATP-competitive inhibitor of Cdks.

Definition

ChEBI: Aminopurvalanol is a purvalanol and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor.

Biological Activity

Cell-permeable cyclin-dependent kinase inhibitor. IC 50 values are 0.033, 0.033, 0.028 and 0.020 μ M for cdk1/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5/p35 respectively. Inhibits ERK1 (IC 50 = 12.0 μ M) and ERK2 (IC 50 = 3.1 μ M) and is 3000-fold selective over a range of other protein kinases (IC 50 > 100 μ M). Arrests cell cycle at G 2 /M boundary (IC 50 = 1.25 μ M), and induces apoptosis at concentrations > 10 μ M.

Enzyme inhibitor

This cell-permeable purvalanol derivative (FW = 403.92 g/mol), also named (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)- 9H-purin-2-yl]amino]-3-methyl-1-butanol, targets cdk1/cyclin B (IC50 = 0.033 μM), cdk2/cyclin A (IC50 = 0.033 μM), cdk2/cyclin E (IC50 = 0.028 μM), and cdk5/p35 (IC50 = 0.020 μM). It also inhibits ERK1 (IC50 = 12 μM) and ERK2 (IC50 = 3.1 μM), with 3000-times greater selectivity versus a range of other protein kinases (IC50 > 100 μM). Aminopurvalanol A arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations > 10 μM.

storage

Store at +4°C

AMINOPURVALANOL A Preparation Products And Raw materials

Raw materials

Preparation Products

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AMINOPURVALANOL A Suppliers

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220792-57-4, AMINOPURVALANOL ARelated Search:

Ro 3306 N9-ISOPROPYL-OLOMOUCINE (S)-ROSCOVITINE NU6140 3-amino-10H-acridine-9-thione ARCYRIAFLAVIN A 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE OLOMOUCINE II SU 9516 NU6102 OLOMOUCINE PURVALANOL A AMINOPURVALANOL A 6-ANILINOPURINE

NG-97

AMINOPURVALANOL A

(2R)-2-[[6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL

AMINOPURVALANOL A (APURV)

1-Butanol, 2-[[6-[(3-amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-

(R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol

inhibit,actin polymerization,Inhibitor,Cyclins,cancer cell differention,G2/M-phase transition,Apoptosis,Aminopurvalanol A,Cyclin dependent kinase,CDK,sperm fertilizing ability

220792-57-4

C19H26ClN7O