6-BROMO-IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID
- Product Name
- 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID
- CAS No.
- 903129-78-2
- Chemical Name
- 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID
- Synonyms
- 6-broMoH-iMidazo[1;6-bromo-1H-imidazo[1,2-a]...;2-a]pyridine-8-carboxylic acid;6-bromo-8-imidazo[1,2-a]pyridinecarboxylic acid;6-BROMO-IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID;IMidazo[1,2-a]pyridine-8-carboxylic acid, 6-broMo-;6-bromo-1H-imidazo[1,2-a]pyridine-8-carboxylic acid
- CBNumber
- CB4166067
- Molecular Formula
- C8H5BrN2O2
- Formula Weight
- 241.04
- MOL File
- Mol file
6-BROMO-IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID Property
- Density
- 1.89±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -1.37±0.41(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB148306
- Product name
- 6-Bromoimidazo[1,2-a]pyridine-8-carboxylicacid
- Packaging
- 50mg
- Price
- $78
- Updated
- 2021/12/16
- Product number
- FB148306
- Product name
- 6-Bromoimidazo[1,2-a]pyridine-8-carboxylicacid
- Packaging
- 100mg
- Price
- $136
- Updated
- 2021/12/16
- Product number
- FB148306
- Product name
- 6-Bromoimidazo[1,2-a]pyridine-8-carboxylicacid
- Packaging
- 250mg
- Price
- $270
- Updated
- 2021/12/16
- Product number
- FB148306
- Product name
- 6-Bromoimidazo[1,2-a]pyridine-8-carboxylicacid
- Packaging
- 500mg
- Price
- $470
- Updated
- 2021/12/16
- Product number
- FB148306
- Product name
- 6-Bromoimidazo[1,2-a]pyridine-8-carboxylicacid
- Packaging
- 1g
- Price
- $818.75
- Updated
- 2021/12/16
6-BROMO-IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
97-97-2
52833-94-0
903129-78-2
GENERAL STEPS: 2-Amino-5-bromonicotinic acid (5.0 g, 23.04 mmol) and sodium acetate (3.78 g, 46.1 mmol) were dissolved in 100 mL of a 60% aqueous ethanol solution under stirring conditions. Subsequently, a solution of 2-chloro-1,1-dimethoxyethane (5.74 g, 46.1 mmol) in water (6 mL) was added to this solution and concentrated hydrochloric acid (1.0 mL) was added dropwise. The reaction mixture was heated to reflux for 2.5 hours. Upon completion of the reaction, the solvent was removed under reduced pressure and the residue was diluted with cold water and the pH adjusted to neutral (about 7) with saturated sodium bicarbonate solution. The reaction mixture was extracted with ethyl acetate (2 x 100 mL), the organic phases were combined, washed sequentially with water (2 x 100 mL) and brine (2 x 100 mL) and dried over anhydrous sodium sulfate. The crude product was purified by grinding with petroleum ether containing 2% ethyl acetate. 4.8 g of 6-bromoimidazo[1,2-a]pyridine-8-carboxylic acid was obtained in 86% yield. The product characterization data were as follows: 1H NMR (DMSO-d6, 300 MHz): δ 7.66 (d, 1H, J = 1.2 Hz, Ar), 7.79 (d, 1H, J = 1.5 Hz, Ar), 8.04 (s, 1H, Ar), 8.96 (d, 1H, J = 1.5 Hz, Ar); MS (ES+): m/e 242 (M + 1 ).
References
[1] Patent: WO2014/80241, 2014, A1. Location in patent: Page/Page column 41
6-BROMO-IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID manufacturers
- Product
- 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID 903129-78-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 100kg; 1000kg
- Release date
- 2019-12-25