ChemicalBook > CAS DataBase List > 1-(2-Methoxyphenyl)piperazine hydrochloride

1-(2-Methoxyphenyl)piperazine hydrochloride

Product Name: 1-(2-Methoxyphenyl)piperazine hydrochloride
CAS No.: 5464-78-8
Chemical Name: 1-(2-Methoxyphenyl)piperazine hydrochloride
Synonyms: OMPP;TIMTEC-BB SBB003293;Urapidil Impurity B;)piperazine hydrochL;LABOTEST-BB LT00159868;Urapidil Impurity 6 HCl;1,3-dimethyl-17-nitrosourea;2-MethoxyphenylPiperazineHCl;o-Methoxyphenyl Piperazine HCl;1-(2-Methoxylphenyl)-Piperazin
CBNumber: CB4166128
Molecular Formula: C11H17ClN2O
Formula Weight: 228.71848
MOL File: 5464-78-8.mol

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1-(2-Methoxyphenyl)piperazine hydrochloride Property

Melting point:: 217-219 °C(lit.)
Boiling point:: 130-133C
Density: 1.106g/cm
refractive index: 1,574-1,576
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO and Methanol.
form: A crystalline solid
Sensitive: Hygroscopic
BRN: 4276925
InChI: InChI=1S/C11H16N2O.ClH/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13;/h2-5,12H,6-9H2,1H3;1H
InChIKey: DDMVHGULHRJOEC-UHFFFAOYSA-N
SMILES: N1(C2=CC=CC=C2OC)CCNCC1.[H]Cl
CAS DataBase Reference: 5464-78-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-28A
RIDADR: UN2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 270067
Product name: 1-(2-Methoxyphenyl)piperazine hydrochloride
Purity: 97%
Packaging: 100g
Price: $80.5
Updated: 2025/07/31

TCI Chemical

Product number: M3643
Product name: 1-(2-Methoxyphenyl)piperazine Hydrochloride
Packaging: 5G
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: M3643
Product name: 1-(2-Methoxyphenyl)piperazine Hydrochloride
Packaging: 25G
Price: $117
Updated: 2025/07/31

Frontier Specialty Chemicals

Product number: JK956738
Product name: 1-(2-Methoxyphenyl)piperazine hydrochloride
Purity: 99%
Packaging: 25g
Price: $32
Updated: 2021/12/16

Matrix Scientific

Product number: 075374
Product name: 1-(2-Methoxyphenyl)piperazine hydrochloride
Purity: 95+%
Packaging: 100g
Price: $116
Updated: 2021/12/16

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1-(2-Methoxyphenyl)piperazine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

1-(2-Methoxyphenyl)piperazine hydrochloride is Off-White Solid

Uses

1-(2-Methoxyphenyl)piperazine hydrochloride is used as reference material for forensic laboratories. It is used in chemical synthesis studies.

Synthesis

95520-98-2

5464-78-8

Procedure for the synthesis of compound 6: In a double necked round bottom flask (RB flask), tert-butyl 4-(2-methoxyphenyl)piperazine-1-carboxylate (Compound 5, 0.600 g, 0.00205 mol, 1 equiv.) was dissolved in ethyl ether (10 mL) followed by addition of ethyl ether hydrochloric acid solution. The reaction mixture was stirred at room temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw material, the ether was removed by evaporation under reduced pressure to give a solid product. The solid product was washed with ethyl acetate and then dried to give the final 1-(2-methoxyphenyl)piperazine hydrochloride (compound 6) as a white solid (0.425 g, 90.08% yield).

References

[1] Patent: US2010/331307, 2010, A1. Location in patent: Page/Page column 19
[2] Patent: WO2011/72174, 2011, A1. Location in patent: Page/Page column 100
[3] Patent: WO2012/3418, 2012, A2. Location in patent: Page/Page column 92

1-(2-Methoxyphenyl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(2-Methoxyphenyl)piperazine hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-(2-Methoxyphenyl)piperazine hydrochloride 5464-78-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-20

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(2-Methoxyphenyl)piperazine hydrochloride 5464-78-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2025-04-01

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Urapidil Impurity 18(Hydrochloride) 5464-78-8
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-03

5464-78-8, 1-(2-Methoxyphenyl)piperazine hydrochlorideRelated Search:

3-(METHOXYMETHOXY)BENZALDEHYDE Piperazine Anisole (Trifluoromethoxy)benzene p-Anisaldehyde Topotecan hydrochloride 4-Methoxyphenylacetone p-Anisidine 4-Methoxybenzylchloride 1-(4-Methoxyphenyl)piperazine 1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine 97% 4-(3-Hydroxypropylamino)-1,3-dimethyluracil 1,3-Propanediamine, N1-(3-chloropropyl)- O-DesMethyl Urapidil 6-[(3-chloropropyl)amino]-1,3-dimethyluracil URAPIDIL 5-METHYL- Urapidil N-Oxide 2-Demethoxy-2-chloro urapidil

LABOTEST-BB LT00159868

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1-(2-METHOXYPHENYL)-PEPIPAZINE HCL

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TIMTEC-BB SBB003293

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o-Methoxyphenyl Piperazine HCl

1-(2-Methoxylphenyl)-Piperazin

1-(2-methoxyphenyl)piperazine hydrochloride (intermediate of naftopidil)

2-MethoxyphenylPiperazineHCl

OMPP

4-(2-Methoxyphenyl)piperazine Hydrochloride

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1(2-Methoxyphenyl)piperazine hydrochloride 99%

1-(2-Methoxyphenyl)piperazine hydrochloride,99%

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1-(2-Methoxyphenyl)piperazine hydrochloride, 99% 50GR

1-(2-methoxylpheny)-piperazine hydrochloride

1-(2-methoxyphenyl)piperazine DIHCL

Urapidil impurity 6 hydrochloride

Urapidil Impurity 6 HCl

)piperazine hydrochL

1-(2-Methoxyphenyl)piperazine HCl / Base

Factory Wholesale 1- (2-Methoxyphenyl) Hydrochloride CAS?5464-78-8?with Fast Delivery

Piperazine, 1-(2-methoxyphenyl)-, hydrochloride (1:1)

1-(2-methoxyphenyl)-Piperazine hydrochloride (1:1)

Urapidil Impurity B

Urapidil Impurity 18(Hydrochloride)

1,3-dimethyl-17-nitrosourea

1-(2-Methoxyphenyl)piperazine hydrochloride, OMPP, TIMTEC-BB SBB003293, Urapidil Impurity B, Piperazine hydrochL, LABOTEST-BB LT00159868, Urapidil Impurity 6 HCl, 2-MethoxyphenylPiperazineHCl, o-Methoxyphenyl Piperazine HCl, 1-(2-Methoxylphenyl)-Piperazin, 1-(o-Methoxyphenyl)piperazineHCl, 1-(2-Methoxyphenyl)piperazinehydrochloride, 1-(2-Methoxylphenyl)-PiperazineHydrochloride99%, 1-(2-Methoxyphenyl)piperazinemonohydrochloride, 1-(o-Methoxyphenyl)piperazineHCl, o-Methoxyphenyl Piperazine HCl, 1-

Urapidil Impurity(Hydrochloride)

5464-78-8

2049025-49-1

C11H16N2OHClC11H17ClN2O

C11H16N2OClH

C11H17N2OCl

C11H17ClN2O

C11H16N2OHCl

Building Blocks

Heterocyclic Building Blocks

Piperazines

PiperazineDerivative

Aromatics

Building Blocks

Heterocyclic Building Blocks

Piperidines, Piperidones, Piperazines

Heterocycles

Piperaizine

Piperazine derivates

Heterocyclic Compounds

(intermediate of naftopidil)