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4-(4-Fluorophenyl)butanoic acid

Product Name
4-(4-Fluorophenyl)butanoic acid
CAS No.
589-06-0
Chemical Name
4-(4-Fluorophenyl)butanoic acid
Synonyms
CHEMBRDG-BB 4002813;TIMTEC-BB SBB010216;4-Fluorobenzenebutanoic acid;4-(p-fluorophenyl)butyric acid;4-(4-FLUOROPHENYL)BUTYRIC ACID;-(4-Fluorophenyl)butanoic acid;Benzenebutanoic acid, 4-fluoro-;4-(4-Fluorophenyl)butanoic acid
CBNumber
CB4168566
Molecular Formula
C10H11FO2
Formula Weight
182.19
MOL File
589-06-0.mol
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4-(4-Fluorophenyl)butanoic acid Property

Melting point:
45 °C
Boiling point:
161-164 °C(Press: 4 Torr)
Density 
1.182±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
4.75±0.10(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
589-06-0(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi,Xn
Risk Statements 
22-41
Safety Statements 
26-39
HazardClass 
IRRITANT
HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B434933
Product name
4-(4-Fluorophenyl)butanoicAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
020616
Product name
4-(4-Fluorophenyl)butyric acid
Purity
97%
Packaging
500mg
Price
$24
Updated
2021/12/16
Matrix Scientific
Product number
020616
Product name
4-(4-Fluorophenyl)butyric acid
Purity
97%
Packaging
1g
Price
$39
Updated
2021/12/16
Oakwood
Product number
032484
Product name
4-(4-Fluorophenyl)butyric acid
Packaging
1g
Price
$39
Updated
2021/12/16
Oakwood
Product number
032484
Product name
4-(4-Fluorophenyl)butyric acid
Packaging
250mg
Price
$15
Updated
2021/12/16
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4-(4-Fluorophenyl)butanoic acid Chemical Properties,Usage,Production

Synthesis

366-77-8

589-06-0

Synthesis of 4-(4-fluorophenyl)butyric acid: 4-(4-fluorophenyl)-4-oxobutanoic acid (0.98 g, 5 mmol) and 85% KOH (0.79 g, 12 mmol) were added to a round bottomed flask fitted with a Dean-Stark apparatus and a reflux condenser and suspended in diethylene glycol (10 mL). 50% hydrazine monohydrate (1.20 g, 12 mmol) was added slowly at room temperature and the reaction mixture was subsequently heated to 120-130 °C and maintained for 2 hours. After about 45 min, the reaction mixture became homogeneous. after 2 h, the temperature was increased to 180-200 °C and stirring was continued for 3 h. Residual hydrazine and water were removed by means of a Dean-Stark water separator. After completion of the reaction, it was cooled to room temperature, diluted with H2O (10 mL) and poured into 2.5N aqueous HCl (20 mL). The organic product was extracted with EtOAc (3 x 15 mL), the organic phases were combined, washed with brine (10 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Purification by column chromatography (30-50% EtOAc/hexane) afforded the target product 4-(4-fluorophenyl)butanoic acid as a clear viscous oil (0.32 g, 35%).1H NMR (500 MHz, CDCl3): δ 11.50 (br, 1H), 7.16 (m, 2H), 7.00 (m, 2H), 2.67 (t, J = 7.6 Hz, 2H), 2.40 (t, J = 7.4 Hz, 2H), 1.97 (quin, J = 7.5 Hz, 2H).13C NMR (125 MHz, CDCl3): δ 180.16, 161.34 (d, J = 243.4 Hz), 136.74, 129.76 (d, J = 7.3 Hz), 115.09 (d, J = 7.3 Hz), 115.09 (d, J = 7.3 Hz), 115.09 (d, J = 7.3 Hz), 115.09 (d, J = 7.3 Hz), 115.09 (d, J = 7.3 Hz) 115.09 (d, J = 20.9 Hz), 34.09, 33.20, 26.24.

References

[1] Patent: US5872118, 1999, A
[2] Patent: US6124284, 2000, A
[3] Patent: US5719186, 1998, A
[4] Archiv der Pharmazie, 1998, vol. 331, # 12, p. 395 - 404
[5] Patent: WO2015/134973, 2015, A1. Location in patent: Page/Page column 98

4-(4-Fluorophenyl)butanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-Fluorophenyl)butanoic acid Suppliers

China 88 Germany 1 India 4 Switzerland 3 Ukraine 1 United Kingdom 11 United States 18 Global 126
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Alfa Aesar
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400-6106006
Fax
021-67582001/03/05
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saleschina@alfa-asia.com
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China
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Energy Chemical
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China
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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86-027-87531808
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China
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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+86-21-54096319
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sales@sinch.com.cn
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China
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Heterochem
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027-88041443 13072715837
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027-51829379
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Shanghai Youd Chemical Technology Co., Ltd.
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021-37910092; 15821801668
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021-37910267
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cong44@126.com
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China
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Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
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China
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Baiyin Chengze Chemical Technology Co., Ltd.
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+86 943-8535351 13389336721
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+86-943-8535351
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sales@chengzechem.com
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China
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View Lastest Price from 4-(4-Fluorophenyl)butanoic acid manufacturers

Career Henan Chemical Co
Product
4-(4-Fluorophenyl)butanoic acid 589-06-0
Price
US $2.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
ask
Release date
2019-12-24

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  • TIMTEC-BB SBB010216
  • CHEMBRDG-BB 4002813
  • 4-(4-FLUOROPHENYL)BUTYRIC ACID
  • 4-(p-fluorophenyl)butyric acid
  • 4-(4-Fluorophenyl)butanoic acid
  • 4-Fluorobenzenebutanoic acid
  • Benzenebutanoic acid, 4-fluoro-
  • -(4-Fluorophenyl)butanoic acid
  • 589-06-0
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