Pemetrexed

Product Name: Pemetrexed
CAS No.: 137281-23-3
Chemical Name: Pemetrexed
Synonyms: PEMETREXED;(S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid;Premetred;PEMETREXED;Pemetrexedum;Pemetrexed99%;Pemetrexedaci;(R)-Pemetrexed;PeMetrexed-15C5;PeMetrexed-13C5
CBNumber: CB4170583
Molecular Formula: C20H21N5O6
Formula Weight: 427.41
MOL File: 137281-23-3.mol

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Pemetrexed Property

Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: slightly sol. in Methanol
form: powder to crystal
pka: 3.58±0.10(Predicted)
color: White to Blue
Merck: 14,7077
CAS DataBase Reference: 137281-23-3(CAS DataBase Reference)

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Safety

RTECS: LZ9950100
HS Code: 2933.99.9701
Hazardous Substances Data: 137281-23-3(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2288
Product name: Pemetrexed Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 250mg
Price: $80
Updated: 2024/03/01

TCI Chemical

Product number: P2288
Product name: Pemetrexed Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $200
Updated: 2024/03/01

Tocris

Product number: 6185
Product name: Pemetrexed
Purity: ≥98%(HPLC)
Packaging: 50
Price: $63
Updated: 2021/12/16

TRC

Product number: A604980
Product name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicAcid
Packaging: 250mg
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BP164240
Product name: Pemetrexed
Packaging: 100mg
Price: $135
Updated: 2021/12/16

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Pemetrexed Chemical Properties,Usage,Production

Chemical Properties

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt is Off-White Solid

Uses

Pemetrexed is used in the treatment of malignant pleural mesothelioma (MPM) and erectile dysfunction therapy.

Definition

ChEBI: Pemetrexed is an N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). It has a role as an antineoplastic agent, an antimetabolite, an EC 2.1.1.45 (thymidylate synthase) inhibitor, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor. It is a pyrrolopyrimidine and a N-acyl-L-glutamic acid. It is a conjugate acid of a pemetrexed(2-).

brand name

Alimta (Lilly).

Side effects

The most common side effects for pemetrexed include fatigue, nausea, vomiting, anorexia, mucositis, myelosuppression ± infection, bleeding, rash, diarrhea and ↑ LFTs.
Severe myelosuppression is often dose-limiting for pemetrexed. Sepsis, in some cases fatal, have occurred in approximately 1% of patients in clinical trials. Prophylactic folic acid and intramuscular vitamin B12 supplements are necessary to reduce hematologic or non-hematologic toxicities.
Pemetrexed may cause serious and in some cases fatal dermatologic toxicities. Rarely, StevensJohnson syndrome and toxic epidermal necrolysis have been reported.

storage

Store at +4°C

Mode of action

Pemetrexed is a pyrrolopyrimidine antifolate that exerts its antineoplastic activity by inhibiting thymidylate synthase (TS), glycinamide ribonucleotide formyltransferase (GARFT) and dihydrofolate reductase (DHFR), which are involved in folate metabolism and DNA synthesis, resulting in inhibition of purine and thymidine nucleotide synthesis.

Pemetrexed Preparation Products And Raw materials

Raw materials

Preparation Products

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Pemetrexed Suppliers

Canada 2 China 261 China Hong Kong 1 Europe 1 France 2 Germany 4 India 46 Israel 1 Italy 2 Japan 1 South Korea 1 United Kingdom 7 United States 32 Global 361

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View Lastest Price from Pemetrexed manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: Pemetrexed 137281-23-3
Price: US $2.54/kg
Min. Order: 1kg
Purity: 99.49
Supply Ability: 60 tons
Release date: 2024-08-23

Hebei Weibang Biotechnology Co., Ltd

Product: PeMetrexed-13C5 137281-23-3
Price: US $9.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2021-10-20

Guangzhou PI PI BIOTECH INC

Product: Pemetrexed 137281-23-3
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 10g
Release date: 2021-09-20

137281-23-3, PemetrexedRelated Search:

Pemetrexed Disodium Pemetrexed disodium hemipentahydrate Pemetrexed Pyrrolo[2,3-d]pyrimidin-4-ol 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine CHEMBRDG-BB 9071517 2-AMINO-5-METHYL-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE CHEMBRDG-BB 9071952 CHEMBRDG-BB 9071469

(S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid

PeMetrexed-13C5

PeMetrexed-15C5

N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-GlutaMic acid (PeMetrexed acid)

N-[4-[2-(2-AMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic acid

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedi

N-[4-[2-(2-Amino-4,7

(2R)-2-{[4-(2-{2-aMino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid

N-(4- 2-(2-AMino-4,7-Dihydro-4-oxo-1H-pyrrol...

PeMetrexed disodiuM INT-6

(S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid

The sour sour of the United States

Pemetrexed Hydrate

Pemetrexed - Labeled 15N,13C5

(R)-Pemetrexed

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentan

PEMETREXED ACID

PEMETREXED

N-(4-[2-(2-Amino-4,7-Dihydro-4-oxo-1H-pyrrolo)[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Gluamic Acid

Pemetrexed99%

L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt

PEFLOXACINMESYLATE

Premetred disodium

Pemetrexedum

Premetred

PemetrexedHydrate&gt

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrroL

)benzamido)pentanedioic acid

3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidi...

PemetrexedQ: What is Pemetrexed Q: What is the CAS Number of Pemetrexed Q: What is the storage condition of Pemetrexed Q: What are the applications of Pemetrexed

PEMETREXED

Pemetrexedaci

137281-23-3

C20H21N5O6xH2O

Anti-cancer & immunity

API

CIALIS