Pemoline Property

Melting point:

255-256°C

Boiling point:

307.77°C (rough estimate)

Density 

1.2662 (rough estimate)

refractive index 

1.5570 (estimate)

storage temp. 

Store at RT

solubility 

DMSO: soluble28mg/mL

pka

pKa 10.5 (Uncertain)

form 

solid

color 

white

CAS DataBase Reference

2152-34-3(CAS DataBase Reference)

NIST Chemistry Reference

4(5H)-oxazolone, 2-amino-5-phenyl-(2152-34-3)

Safety

Hazard Codes 

Xn,C,F,T

Risk Statements 

22-34-11-20/21/22

Safety Statements 

16-26-36/37/39-45-36/37-36

WGK Germany 

3

RTECS 

PB8750000

Hazardous Substances Data

2152-34-3(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 500 mg/kg (Schafer)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Pemoline Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Deltamine,Aron,France,1960

Uses

A CNS stimulant. Controlled Substance

Definition

ChEBI: A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.

Manufacturing Process

It is preferably prepared by reacting mandelic acid ethyl ester with guanidine in boiling alcoholic solution whereby it is obtained as difficultly soluble precipitate with a yield of 90%.
This compound is a white, crystalline compound melting at 256°-257°C with decomposition. It is readily soluble in concentrated aqueous alkali hydroxide solutions and in concentrated aqueous mineral acids.

brand name

Cylert (Abbott).

Therapeutic Function

Psychostimulant

World Health Organization (WHO)

Pemoline was introduced in 1975 for the treatment of attentiondeficit disorder. Because of its central stimulating effects it has also been used in weight control in combination with anorectic agents, laxatives.

General Description

Pemoline, 2-amino-5-phenyl-4(5H)-oxazolone (Cylert), hasa unique structure.
The compound is described as having an overall effect onthe CNS like that of methylphenidate. Pemoline requires 3to 4 weeks of administration, however, to take effect. A partialexplanation for the delayed effect may be that one of theactions of the agent, as observed in rats, is to increase therate of synthesis of DA.

Biological Activity

Long-acting central stimulant that induces self-injurious behavior in rats. Acts as an indirect monoamine agonist.