D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE

ChemicalBook > CAS DataBase List > D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE

D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE

Product Name: D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
CAS No.: 26993-30-6
Chemical Name: D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
Synonyms: SPA;S1P;SPHINGOSINE-1-PHOSPHATE;1-SPP;SPN-1-P;SPHINGOSINE-1-PO4;Quetiapine Impurity 54-d8;SPHINGOSINE-1-PHOSPHORIC ACID;Sphingosine-1-phosphate (d18:1);D-erythro-Sphingosin-1-phosphate
CBNumber: CB4181497
Molecular Formula: C18H38NO5P
Formula Weight: 379.47
MOL File: 26993-30-6.mol

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D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Property

Melting point:: 179-189°C
Boiling point:: 548.8±60.0 °C(Predicted)
Density: 1.094±0.06 g/cm3(Predicted)
RTECS: RG2260500
storage temp.: -20°C
solubility: methanol: THF: water (6:3:1): >0.5 mg/mL
form: waxy solid
pka: 1.76±0.10(Predicted)
color: yellow
Sensitive: Light Sensitive
Stability:: Moisture, Temperature Sensitive; Hygroscopic
CAS DataBase Reference: 26993-30-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29225090
DEA Controlled Substances: CSCN: 1635
CAS SCH: IV
NARC: N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 73914
Product name: Sphingosine 1-phosphate
Purity: ≥98.0% (TLC)
Packaging: 1mg
Price: $320
Updated: 2024/03/01

Sigma-Aldrich

Product number: 567727
Product name: Sphingosine 1-phosphate
Packaging: 1mg
Price: $239
Updated: 2024/03/01

Alfa Aesar

Product number: J66459
Product name: Sphingosine 1-phosphate
Packaging: 1mg
Price: $228
Updated: 2023/06/20

Alfa Aesar

Product number: J66459
Product name: Sphingosine 1-phosphate
Packaging: 5mg
Price: $784
Updated: 2023/06/20

Cayman Chemical

Product number: 62570
Product name: Sphingosine 1-phosphate
Purity: ≥98%
Packaging: 1mg
Price: $74
Updated: 2024/03/01

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D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Chemical Properties,Usage,Production

Description

Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P₁ and G_qi5, which allows for phospholipase C stimulation by G_i proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P₂ and S1P₃ receptors (EC₅₀s = 8 and 11 nM, respectively). Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity. S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.

Chemical Properties

Off-White to Grey Powder

Uses

A ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12.

Uses

A putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrations with no toxic effects thereby making it a possible agent for prevention of tumor cell metastasis and inflammatory processes. It mobilizes intracellular calcium stores, decreases cellular cAMP, activates phospholipase D and does not inhibitprotein kinase C.

Uses

D-erythro-Dihydrosphingosine-1-phosphate is a saturated analog of D-erythro-Sphingosine-1-phosphate a putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrations with no toxic effects thereby making it a possible agent for prevention of tumor cell metastasis and inflammatory processes.

Definition

ChEBI: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1

General Description

Sphingosine-1-phosphate (S1P), a sphingolipid, is an important cellular metabolite and signaling lipid in animal cells. It has also been found in yeasts and plants. Sphingosine kinases (SPKs) catalyzes the synthesis of S1P from spingosine and regulates S1P levels. It is the end product of ceramide catabolism and is metabolized to phosphoethanolamine and hexadecenal by S1P lyase. S1P is produced in endothelial cells.

Biological Activity

Endogenous second messenger involved in the control of cell proliferation and motility, and Ca 2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors, S1P 1-5 . Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.

Biochem/physiol Actions

A lipid second messenger that binds to S1P1 and S1P3 receptors. Mobilizes intracellular Ca2+ stores and decreases cellular cAMP. Activates phospholipase D. S1P stimulates the migration of endothelial cells but inhibits the migration of other cell types. Induces angiogenesis.

storage

Store at +4°C

References

1) Spiegel and Milstien (2003)?Sphingosine-1-phosphate: an enigmatic signaling lipid; Nat. Rev. Mol. Cell Biol.,?4?397 2) Rosen?et al. (2009)?Sphingosine-1-phosphate receptor signaling; Annu. Rev .Biochem.,?78?743 3) Maceyka?et al. (2012)?Sphingosine-1-phosphate signaling and its role in disease; Trends Cell Biol.,?22?50

D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Preparation Products And Raw materials

Raw materials

Preparation Products

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D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Suppliers

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View Lastest Price from D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE manufacturers

Career Henan Chemical Co

Product: Sphingosine 1-phosphate 26993-30-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-25

26993-30-6, D-ERYTHRO-SPHINGOSINE-1-PHOSPHATERelated Search:

(-)PPP BORRELIDIN Roscovitine NVP-BEZ 235 Dihydrosphingosine(sphinganine) SPHINGOMYELIN D-ERYTHRO-SPHINGOSINE CAGED D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE-13C2,D2 D-erythro-dihydro-D-sphingosine-1-phosphate D-ERYTHRO-SPHINGOSINE 1-PHOSPHATE (CAGED) N-ACETYL-D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE, [ACETYL-1-14C] D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE, N-OCTANOYL-

1-SPP

D-erythro-Sphingosine-1-phosphate - CAS 26993-30-6 - Calbiochem

(E)-D-ERYTHRO-2-AMINO-1-(DIHYDROGENPHOSPHATE)-4-OCTADECENE-1,3-DIOL

D-ERYTHRO-DIHYDROSPHINGOSINE-1-PHOSPHATE

D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE

SPA

SPHINGOSINE-1-PHOSPHATE

SPHINGOSINE-1-PHOSPHATE, D-ERYTHRO

SPHINGOSINE-1-PHOSPHORIC ACID

SPHINGOSINE-1-PO4

SPN-1-P

S1P

SHINGOSINE-1-PHOSPHATE \ EDG-1 RECEPTOR

D-erythro-Sphingosine 1-phosphate,96%

D-erythro-Sphingosin-1-phosphate

1,3-Octadecanediol, 2-amino-, 1-(dihydrogen phosphate), D-erythro- (8C I)

(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate

Sphingosine-1-phosphate (d18:1)

(2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid

(2S,3R,4E)-2-AMino-4-octadecene-1,3-diol 1-(Dihydrogen phosphate)

(2S,3R,E)-2-aMino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate

4-[(9-β-D-Ribofuranosyl-9H-purin-6-yl)amino]-benzenesulfonic acid sodium-potassium salt

4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-

Mouse Sphingosine-1-phosphate elisa kit

(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate

Quetiapine Impurity 54-d8

D-erythro Sphingosine-1-phosphate, agonist of S1P receptors

26993-30-6

C18H38NO5P

proteins

Chemical Activators

Activators

Fatty Acid Derivatives & Lipids

Glycerols

Inhibitors

Protein Kinase Inhibitors and Activators

Angiogenic FactorsSphingolipids

Angiogenesis

Cancer Research

Lipids in Cell Signaling

Sphingoid base 1-phosphatesCell Signaling and Neuroscience

Sphingoid bases

Sphingolipids

Lysophospholipid receptor and related