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Isofagomine D-Tartrate

Product Name
Isofagomine D-Tartrate
CAS No.
957230-65-8
Chemical Name
Isofagomine D-Tartrate
Synonyms
Isofagomine tartrate;Isofagomine D-Tartrate;D-Isofagomine D-Tartrate;Afegostat DTartrate,Afegostat D Tartrate;Afegostat D-Tartrate (D-Isofagomine (D-Tartrate);Afegostat D-Tartrate (Synonyms: D-Isofagomine (D-Tartrate);(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate
CBNumber
CB41873108
Molecular Formula
C10H19NO9
Formula Weight
297.26
MOL File
957230-65-8.mol
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Isofagomine D-Tartrate Property

Melting point:
124-126°C
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
Soluble in DMSO (up to 2 mg/ml)
form 
solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16137
Product name
Isofagomine (D-tartrate)
Purity
≥95%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
16137
Product name
Isofagomine (D-tartrate)
Purity
≥95%
Packaging
5mg
Price
$202
Updated
2024/03/01
Cayman Chemical
Product number
16137
Product name
Isofagomine (D-tartrate)
Purity
≥95%
Packaging
10mg
Price
$364
Updated
2024/03/01
Usbiological
Product number
293800
Product name
Isofagomine D-tartrate
Packaging
5mg
Price
$460
Updated
2021/12/16
TRC
Product number
I816010
Product name
IsofagomineD-Tartrate
Packaging
5mg
Price
$180
Updated
2021/12/16
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Isofagomine D-Tartrate Chemical Properties,Usage,Production

Description

Isofagomine tartrate (957230-65-8) is a competitive inhibitor of human lysosomal β-glucosidase, IC50?= 0.06 μM.1?Increases the activity of N370S mutant acid β-glucosidase (GlcCerase) in Gaucher fibroblasts.2?Displays a direct pharmacological chaperone effect greatly increasing the amount of newly synthesized GlcCerase that traffics out of the ER.2

Chemical Properties

Isofagomine D-Tartrate is Off-White Solid

Uses

Isofagomine D-Tartrate is used as human acid ?glucosidase inhibitor and for the treatment of Gaucher disease

Uses

Used as human acid β-glucosidase inhibitor and for the treatment of Gaucher disease.

References

1) Kuriyama?et al.?(2008),?In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell culture; Bioorg. Med. Chem.,?16?7330 2) Steet?et al. (2006),?The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms; Proc. Natl. Acad. Sci. USA,?103?13813

Isofagomine D-Tartrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Isofagomine D-Tartrate Suppliers

J & K SCIENTIFIC LTD.
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957230-65-8, Isofagomine D-TartrateRelated Search:


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