Z-NVA-OH

Product Name: Z-NVA-OH
CAS No.: 21691-44-1
Chemical Name: Z-NVA-OH
Synonyms: Z-NVA-OH;Cbz-Nva-OH;Z-L-Nva-OH;Z-NORVALINE;Z-APE(2)-OH;CBZ-L-NVA-OH;Z-L-NORVALINE;Z-Nva-OH ,98%;CBZ-L-NORVALINE;Z-L-norvaline99%
CBNumber: CB4187707
Molecular Formula: C13H17NO4
Formula Weight: 251.28
MOL File: 21691-44-1.mol

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Z-NVA-OH Property

Boiling point:: 439.4±38.0 °C(Predicted)
Density: 1.184±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 4.00±0.20(Predicted)
CAS DataBase Reference: 21691-44-1(CAS DataBase Reference)

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Safety

HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Usbiological

Product number: 285602
Product name: Z-L-norvaline
Packaging: 10g
Price: $363
Updated: 2021/12/16

Activate Scientific

Product number: AS29383
Product name: N-Cbz-L-norvaline
Purity: 95+% ee
Packaging: 100g
Price: $389
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4158-1-S4
Product name: Cbz-L-Norvaline
Packaging: 100g
Price: $456
Updated: 2021/12/16

Activate Scientific

Product number: AS29383
Product name: N-Cbz-L-norvaline
Purity: 95+% ee
Packaging: 5G
Price: $57
Updated: 2021/12/16

AK Scientific

Product number: V4383
Product name: Z-Nva-OH
Packaging: 100g
Price: $602
Updated: 2021/12/16

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Z-NVA-OH Chemical Properties,Usage,Production

Uses

Z-NVA-OH is also known as Cbz-L-norvaline. It could be used to synthesise Z-Nva-Ser(Bu’)-Gly-OPh. In specific steps, as follows: the protected dipeptide(53.1 g. 124mM) and Tos.OH.H2O (33.6g. 124mM) were dissolved in DMF (200) and hydrogenolysed overnight in the presence of 10% Pd/C (6g), then filtered and concentrated to 100ml. Z-Nva-OH (37.4g. 149mM) was dissolved in CH2Cl2 (170ml) and NMM (16.4ml. 149mM) added. After cooling to -20℃, pivaloyl chloride (17.8ml. 145 mM) was added, and the solution was stirred for 20 minutes before the precooled DMF solution from above was added. Following the addition of NMM (13.6 ml, 124 mM), the reaction was stirred at - 20℃ for 3 hr, then maintained at room temperature overnight. The solution was evaporated, and the product dissolved in EtOAc. Washing with acid and base in the usual way, followed by crystallisation from EtOAc/petroleum ether yielded Z-Nva-Ser(Bu’)-Gly-OPh[1].

References

[1] I.J. Galpin. “Peptides—XXXXII.” Tetrahedron 37 17 (1981): Pages 3017-3023.

Z-NVA-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-NVA-OH Suppliers

Canada 1 China 156 Germany 4 India 5 Japan 4 Switzerland 1 United Kingdom 3 United States 15 Global 189

BOC Sciences

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View Lastest Price from Z-NVA-OH manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Z-NVA-OH 21691-44-1
Price: US $0.00/Kg/Bag
Min. Order: 100g
Purity: 99.0%min
Supply Ability: 500kgs
Release date: 2021-08-23

Career Henan Chemical Co

Product: Z-NVA-OH 21691-44-1
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-31

21691-44-1, Z-NVA-OHRelated Search:

N-Benzyloxycarbonyl-N'-(tert-Butoxycarbonyl)-L-lysine N-Cbz-L-Aspartic acid 4-benzyl ester Z-N-ME-GLU(OTBU)-OH Z-NVA-OSU Cbz-Valine ganciclovir 9-MethoxyMethyl Guanine N-Carboxybenzyl D-Valacyclovir S, S-Isovalganciclovir Impurity Ganciclovir Impurity 3 Valaciclovir EP Impurity H N-t-Boc-valacyclovir N-Methyl Valganciclovir Hydrochloride [2-(2-Amino-6-chloro-9H-purin-9-yl)ethyl]propanedioic acid dimethyl ester N-ForMyl Valacyclovir N-T-BOC-VALACYCLOVIR-D4 H-MEVAL-OH HCL Valaciclovir Ep Impurity C 194155-99-2

BENZYLOXYCARBONYL-L-NORVALINE

Norvaline reference substance

CBZ-L-NORVALINE

Z-APE(2)-OH

Z-L-ALPHA-AMINOVALERIC ACID

Z-L-2-AMINOVALERIC ACID

Z-NVA-OH

Z-NORVALINE

Z-L-NHCH[CH3(CH2)2]-COOH

Z-L-NORVALINE

RARECHEM AL CF 0968

N-CBZ-L-NORVALINE

N-CARBOBENZOXY-L-NORVALINE

N-ALPHA-CARBOBENZOXY-L-NORVALINE

N-ALPHA-CARBOBENZOXY-L-2-AMINO-PENTANOIC ACID

N-ALPHA-CBZ-L-NORVALINE

Cbz-Nva-OH

NALPHA-Benzyloxycarbonyl-L-norvaline

N-alpha-Benzyloxycarbonyl-L-norvaline, (S)-N-alpha-Z-2-amino-valeric acid

Z-L-Nva-OH

Z-L-NORVALINE extrapure

N-Carbobenzoxy-DL-norvaline

N-Cbz-DL-norvaline

Z-Nva-OH ,98%

Z-L-a-aMinovaleric acid

(2S)-2-{[(benzyloxy)carbonyl]aMino}pentanoic acid

L-Norvaline, N-[(phenylmethoxy)carbonyl]-

Z-L-norvaline99%

(2S)-2-(phenylmethoxycarbonylamino)pentanoic acid

2-(phenylmethoxycarbonylamino)pentanoic acid

Valacyclovir Impurity 5

Valacyclovir Impurity 5 (N-Cbz-L-Norvaline)

Valacyclovir Impurity 26

(2S)-2-(phenylmethoxycarbonylamino)pentanoicaci

Z-NVA-OH USP/EP/BP

CBZ-L-NVA-OH

Diethylcarbamazine Impurity 2（Diethylcarbamazine EP Impurity B）

21691-44-1

Peptide