ChemicalBook > CAS DataBase List > 4-BROMO-2-METHOXYBENZOIC ACID

4-BROMO-2-METHOXYBENZOIC ACID

Product Name
4-BROMO-2-METHOXYBENZOIC ACID
CAS No.
72135-36-5
Chemical Name
4-BROMO-2-METHOXYBENZOIC ACID
Synonyms
5-Bromo-2-carboxyanisole;4-BROMO-2-METHOXYBENZOIC ACID;2-Methoxy-4-bromobenzoic acid;Benzoic acid,4-broMo-2-Methoxy-
CBNumber
CB4188012
Molecular Formula
C8H7BrO3
Formula Weight
231.04
MOL File
72135-36-5.mol
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4-BROMO-2-METHOXYBENZOIC ACID Property

Melting point:
155-159°C
Boiling point:
318.1±27.0 °C(Predicted)
Density 
1.625±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
3.86±0.10(Predicted)
form 
powder
color 
Off white
InChI
InChI=1S/C8H7BrO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4H,1H3,(H,10,11)
InChIKey
CEZLPETXJOGAKX-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(Br)C=C1OC
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25
Safety Statements 
45
RIDADR 
2811
WGK Germany 
3
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
734802
Product name
4-Bromo-2-methoxybenzoic acid
Purity
97%
Packaging
1g
Price
$18.2
Updated
2023/06/20
TRC
Product number
B699570
Product name
4-Bromo-2-methoxybenzoic acid
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB55634
Product name
4-Bromo-2-methoxybenzoic acid
Packaging
100g
Price
$100
Updated
2021/12/16
Matrix Scientific
Product number
024997
Product name
4-Bromo-2-methoxybenzoic acid
Purity
98%
Packaging
25g
Price
$109
Updated
2021/12/16
AK Scientific
Product number
X2798
Product name
4-Bromo-2-methoxybenzoic acid
Packaging
25g
Price
$151
Updated
2021/12/16
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4-BROMO-2-METHOXYBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

Pale yellow liquid

Uses

4-Bromo-2-methoxybenzoic acid is a nucleophilic reagent that can be used to synthesize other compounds.

Reactions

4-Bromo-2-methoxybenzoic acid reacts with lithium aluminium hydride (LiAlH) and aluminium hydride (AlH) to produce lithium 4-bromo-2-methoxybenzoate and aluminium 4-bromo-2-methoxybenzoate, respectively. These compounds are used in organic synthesis as Grignard reagents for the introduction of methoxy groups.

Synthesis

1666-28-0

74-88-4

72135-36-5

General procedure for the synthesis of 2-methoxy-4-bromobenzoic acid from 2-hydroxy-4-bromobenzoic acid and iodomethane: 1. in a dry reaction flask, 2-hydroxy-4-bromobenzoic acid (1.2 g, 5.53 mmol) was dissolved in N,N-dimethylformamide (30 mL). 2. Potassium carbonate (2.3 g, 16.59 mmol) and iodomethane (861 μL, 13.83 mmol) were added to the above solution. 3. The reaction mixture was stirred at room temperature for 18 h. 4. 4. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the solvent. 5. The residue was dissolved in ethyl acetate and washed with deionized water. 6. 6. The aqueous layer was separated and back-extracted with ethyl acetate (2×). 7. All organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. 8. After filtration to remove the desiccant, the filtrate was concentrated under vacuum to give 2-methoxy-4-bromobenzoic acid as an orange oil (1.27 g, 94% yield). 9. The product was characterized by 1H NMR (400 MHz, CDCl3) and LRMS APCI: 1H NMR δ 3.88 (s, 1H), 3.90 (s, 3H), 7.11-7.15 (m, 2H), 7.68 (d, 1H); LRMS APCI m/z 245/247 [M + H]+ .

References

[1] Patent: WO2006/100588, 2006, A1. Location in patent: Page/Page column 55-56

4-BROMO-2-METHOXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-2-METHOXYBENZOIC ACID Suppliers

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View Lastest Price from 4-BROMO-2-METHOXYBENZOIC ACID manufacturers

Career Henan Chemical Co
Product
4-BROMO-2-METHOXYBENZOIC ACID 72135-36-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg;10kg;100kg
Release date
2019-08-29

72135-36-5, 4-BROMO-2-METHOXYBENZOIC ACIDRelated Search:

4-BROMO-2-METHOXYBENZALDEHYDE 4-BROMO-3-METHOXYBENZOIC ACID METHYL ESTER 3-BROMO-4-METHOXYBENZOIC ACID,3-Bromo-4-methoxybenzoic acid, 98+% 2-Bromo-5-methoxybenzoic acid, 98+%,2-BROMO-5-METHOXYBENZOIC ACID,2-BROMO-5-METHOXYBENZOIC ACID 98% 3-Bromo-2-methoxybenzoic acid METHYL 4-BROMO-2-METHOXYBENZOATE 98 2-BROMO-6-METHOXYBENZOIC ACID 5-BENZOYLOXY-2-BROMO-4-METHOXYBENZOIC ACID 4-Bromo-3-methoxybenzoic acid 5-BROMO-2-METHOXYBENZOIC ACID,5-Bromo-2-methoxybenzoic acid 5-Bromo-o-anisic acid 2-Bromo-5-methoxybenzoic acid hydrazide 4-Acetamido-5-bromo-2-methoxybenzoic acid methyl ester 2-BROMO-5-METHOXYBENZOIC ACID METHYL ESTER 4-BROMO-2-METHOXYBENZOIC ACID ETHYL ESTER 4-BROMO-2,5-DIMETHOXYBENZOIC ACID TERT-BUTYL 4-BROMO-2-METHOXYBENZOATE 4-BROMO-2-METHOXYBENZOIC ACID 4-BROMO-2-METHOXYBENZOIC ACID METHYL ESTER

  • 4-BROMO-2-METHOXYBENZOIC ACID
  • Benzoic acid,4-broMo-2-Methoxy-
  • 2-Methoxy-4-bromobenzoic acid
  • 5-Bromo-2-carboxyanisole
  • 72135-36-5
  • 72135-35-6
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Acids & Esters
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Bromine Compounds