ChemicalBook > CAS DataBase List > 5,6-DICHLORO-3-PYRIDINEMETHANOL

5,6-DICHLORO-3-PYRIDINEMETHANOL

Product Name: 5,6-DICHLORO-3-PYRIDINEMETHANOL
CAS No.: 54127-30-9
Chemical Name: 5,6-DICHLORO-3-PYRIDINEMETHANOL
Synonyms: Dichloropyridinemethanol;5,6-DICHLORONICOTINYL ALCOHOL;5,6-DICHLORO-3-PYRIDINEMETHANOL;2,3-Dichloro-5-pyridinemethanol;3-Pyridinemethanol, 5,6-dichloro-;5,6-Dichloro-3-pyridinemethanol>(5,6-Dichloro-3-pyridinyl)methanol;(5,6-dichloropyridin-3-yl)methanol;5,6-dichloro-3-pyridinemethanol96+%;2,3-DICHLORO-5-HYDROXYMETHYLPYRIDINE
CBNumber: CB4191359
Molecular Formula: C6H5Cl2NO
Formula Weight: 178.02
MOL File: 54127-30-9.mol

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5,6-DICHLORO-3-PYRIDINEMETHANOL Property

Melting point:: 76°C
Boiling point:: 297.7±35.0 °C(Predicted)
Density: 1.478
storage temp.: Sealed in dry,Store in freezer, under -20°C
form: powder to crystal
pka: 12.96±0.10(Predicted)
color: White to Gray to Brown

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D2402
Product name: 5,6-Dichloro-3-pyridinemethanol
Purity: >96.0%(GC)
Packaging: 1g
Price: $139
Updated: 2025/07/31

TCI Chemical

Product number: D2402
Product name: 5,6-Dichloro-3-pyridinemethanol
Purity: >96.0%(GC)
Packaging: 5g
Price: $481
Updated: 2025/07/31

TRC

Product number: D436190
Product name: 5,6-Dichloro-3-pyridinemethanol
Packaging: 5g
Price: $375
Updated: 2021/12/16

Apolloscientific

Product number: OR17551
Product name: 2,3-Dichloro-5-(hydroxymethyl)pyridine
Purity: 95+%
Packaging: 1g
Price: $67
Updated: 2021/12/16

Matrix Scientific

Product number: 056477
Product name: (5,6-Dichloropyridin-3-yl)methanol
Purity: >95%
Packaging: 1g
Price: $69
Updated: 2021/12/16

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5,6-DICHLORO-3-PYRIDINEMETHANOL Chemical Properties,Usage,Production

Uses

5,6-Dichloro-3-pyridinemethanol acts as a novel CXCR3 (CXC chemokine receptor) inhibitor. It also is used in the synthesis of pyridine-based histone deacetylase inhibitors.

Synthesis

41667-95-2

54127-30-9

The general procedure for the synthesis of 5,6-dichloro-3-pyrimidinemethanol from 5,6-dichloropyridine-3-carboxylic acid was as follows: 859 mL (859 mmol) of a tetrahydrofuran solution of 1 M borane/tetrahydrofuran complex was slowly added dropwise to 110 g (573 mmol) of 5,6-dichloronicotinic acid in 250 mL of a tetrahydrofuran solution at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously at that temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to 0°C and subsequently adjusted to alkaline with saturated aqueous potassium carbonate solution. Most of the tetrahydrofuran was removed on a rotary evaporator and the residue was extracted several times with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated aqueous sodium chloride, and then dried over sodium sulfate. The organic phases were concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (silica gel 60-Merck, particle size: 0.04 to 0.063 mm) with ethyl acetate:cyclohexane (1:2) as the mobile phase, resulting in 62 g (61% yield) of (5,6-dichloropyridin-3-yl)methanol. The product was characterized by 1H-NMR (CD3CN): δ[ppm] = 3.31 (t, 1H), 4.60 (d, 2H), 7.85 (s, 1H), 8.26 (s, 1H).

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 13, p. 5620 - 5637
[2] Patent: US2009/181947, 2009, A1. Location in patent: Page/Page column 39
[3] Patent: US2009/247551, 2009, A1. Location in patent: Page/Page column 27
[4] Patent: US2010/48646, 2010, A1. Location in patent: Page/Page column 25
[5] Patent: US6737435, 2004, B1. Location in patent: Page/Page column 18

5,6-DICHLORO-3-PYRIDINEMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6-DICHLORO-3-PYRIDINEMETHANOL Suppliers

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