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2-Hydroxybenzylamine

Product Name
2-Hydroxybenzylamine
CAS No.
932-30-9
Chemical Name
2-Hydroxybenzylamine
Synonyms
2-(Aminomethyl)phenol;2-HydroxybenzyL;Phenol, 2-(aminomethyl)-;2-HOBA;NSC 127870;Salicylamine;α-AMino-o-cresol;o-HydroxybenzylaMine;2-Hydroxybenzylamine;2-Hydroxybenzylamine,98%
CBNumber
CB4197977
Molecular Formula
C7H9NO
Formula Weight
123.15
MOL File
932-30-9.mol
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2-Hydroxybenzylamine Property

Melting point:
127 °C
Boiling point:
245.0±15.0 °C(Predicted)
Density 
1.141±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Methanol (Very Slightly, Heated)
form 
Solid
pka
8.63±0.35(Predicted)
color 
Beige to Brown
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29222990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS008020
Product name
2-(aminomethyl)phenol
Purity
Aldrich
Packaging
250mg
Price
$209
Updated
2024/03/01
Cayman Chemical
Product number
25357
Product name
2-HOBA
Purity
≥98%
Packaging
250mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
25357
Product name
2-HOBA
Purity
≥98%
Packaging
500mg
Price
$84
Updated
2024/03/01
Cayman Chemical
Product number
25357
Product name
2-HOBA
Purity
≥98%
Packaging
1g
Price
$155
Updated
2024/03/01
Cayman Chemical
Product number
25357
Product name
2-HOBA
Purity
≥98%
Packaging
5g
Price
$680
Updated
2024/03/01
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2-Hydroxybenzylamine Chemical Properties,Usage,Production

Description

2-Hydroxybenzylamine (2-HOBA), also known as salicylamide, is a potent γKA scavenger that scavenges γKAs 980-fold faster than the formation of γKA protein adducts and therefore protects cells from the deleterious effects of γKA adducts. 2-HOBA is currently being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl electrophile formation, such as the cognitive decline observed with Mild Cognitive Impairment or Alzheimer's disease.

Chemical Properties

white to light yellow crystal powder.

Uses

2-Hydroxybenzylamine is a potent γ-ketoaldehyde scavenger that has been shown to protects cardiac sodium channel (NaV1.5) from oxidant-induced inactivation.

Production Methods

A simplified method for extracting 2-hydroxybenzylamine from buckwheat is as follows:
1. Dry the roots, stems, and seeds of buckwheat separately. Grind them into a powder using liquid nitrogen.
2. Mix the powder with deionized water and adjust the pH of the solution to 5.0. Add an enzyme mixture consisting of cellulase and pectinase, with a weight ratio of 2:1 to the powder. Perform enzymatic hydrolysis at a temperature of 25°C for 40 minutes. Filter the mixture after hydrolysis.
3. Mix the filter residue obtained in step 2 with 95% ethanol using a solid-liquid ratio of 1g:10mL. Perform ultrasonic extraction at an ultrasound power density of 100W/cm2, ultrasound frequency of 30kHz, extraction temperature of 20°C, and extraction time of 30 minutes. Repeat the extraction process three times, filter the extracts, and combine them.
4. Concentrate the supernatant obtained in step 3 under reduced pressure to obtain a Chemicalbook extract. Add a 3 wt% sodium hydroxide solution to dissolve the extract. Filter the solution to obtain the filtrate.
5. Adjust the filtrate obtained in step 4 to pH 3 using hydrochloric acid, resulting in an adjusted solution. Pass the adjusted solution through an NDA-150 resin column at a temperature of 20°C and a flow rate of 10 BV/h until saturated adsorption is achieved.
6. After reaching saturated adsorption, elute the filtrate obtained in step 4 with an 8 wt% sodium hydroxide solution at 50°C and a flow rate of 2 BV/h. Collect twice the volume of the column volume. Then, elute the filtrate obtained in step 5 with a 3 wt% sodium hydroxide solution at 50°C and a flow rate of 2 BV/h. Collect once the volume of the column volume. Lastly, elute the filtrate obtained in step 5 with water at 60°C and a flow rate of 3 BV/h. Collect once the volume of the column volume. Combine the three eluents.
7. Concentrate the combined eluents under reduced pressure and recrystallize them using edible alcohol. Separate the crystals to obtain 2-hydroxybenzylamine.

Synthesis Reference(s)

Tetrahedron, 48, p. 4301, 1992 DOI: 10.1016/S0040-4020(01)80441-5

2-Hydroxybenzylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxybenzylamine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35906
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11605
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
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60
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18736
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
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57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
13761588971 13761588971
Fax
021 51613951
Email
vivian.zhu@3wpharm.com
Country
China
ProdList
9840
Advantage
57
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View Lastest Price from 2-Hydroxybenzylamine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Hydroxybenzylamine 932-30-9
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-29
Hebei Guanlang Biotechnology Co,.LTD
Product
2-Hydroxybenzylamine 932-30-9
Price
US $9.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
100tons
Release date
2022-01-21
Honest Joy Holdings Limited
Product
2-Hydroxybenzylamine 932-30-9
Price
US $0.00/KG
Min. Order
1KG
Purity
97.2%
Supply Ability
100 tons
Release date
2022-02-22

932-30-9, 2-HydroxybenzylamineRelated Search:


  • 2-(3-CHLOROPHENOXY)MALONDIALDEHYDE
  • 2-HYDROXYBENZYLAMINE[2-(AMINOMETHYL)PHENOL]
  • Phenol, 2-(aminomethyl)-
  • 2-(Aminomethyl)phenol
  • 2-Hydroxybenzylamine
  • 2-Hydroxybenzylamine, (2-Hydroxyphenyl)methylamine
  • 2-HydroxybenzylaMine, 98% 1GR
  • 2-HydroxybenzeneMethanaMine
  • NSC 127870
  • o-HydroxybenzylaMine
  • α-AMino-o-cresol
  • Salicylamine
  • 2-Hydroxybenzylamine,98%
  • 2-HOBA
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  • 2-Hydroxybenzylamine USP/EP/BP
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  • 932-30-9
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aminomethyl's
  • Phenyls & Phenyl-Het
  • Amine
  • Phenyls & Phenyl-Het
  • Anilines, Aromatic Amines and Nitro Compounds