ChemicalBook > CAS DataBase List > 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name
4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.
130636-61-2
Chemical Name
4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms
BUTTPARK 36\08-67;1-Boc-4-(4-nitrobenzyl)piperazine;N2-{[(2-Methyl-2-Propanyl)Oxy]Carbonyl}-L-Glutamine;1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine;tert-butyl 4-[(4-nitrophenyl)Methyl]piperazine-1-carboxylate;4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%;4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylic acid tert-butyl ester;tert-butyl 4-[(4-nitrophenyl)methyl]piperazine-1-carboxylate - [AC77724];4-[(4-NITROPHENYL)METHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
CBNumber
CB4199461
Molecular Formula
C16H23N3O4
Formula Weight
321.37
MOL File
130636-61-2.mol
More
Less

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Melting point:
99-100 °C
Boiling point:
436.5±40.0 °C(Predicted)
Density 
1.208±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
5.49±0.10(Predicted)
Appearance
White to light yellow Solid
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B656773
Product name
1-Boc-4-(4-Nitrobenzyl)piperazine
Packaging
250mg
Price
$45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0002708
Product name
4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity
95.00%
Packaging
250MG
Price
$187.95
Updated
2021/12/16
Matrix Scientific
Product number
071894
Product name
1-Boc-4-(4-Nitrobenzyl)piperazine
Purity
95+%
Packaging
1g
Price
$278
Updated
2021/12/16
AK Scientific
Product number
X9773
Product name
1-Boc-4-(4-Nitrobenzyl)piperazine
Packaging
25g
Price
$717
Updated
2021/12/16
Matrix Scientific
Product number
071894
Product name
1-Boc-4-(4-Nitrobenzyl)piperazine
Purity
95+%
Packaging
5g
Price
$759
Updated
2021/12/16
More
Less

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

100-11-8

57260-71-6

130636-61-2

General procedure for the synthesis of tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate from 4-nitrobenzyl bromide and N-BOC-piperazine: Potassium carbonate (3 g) was added to a solution containing tert-butyl 1-piperazinecarboxylate (0.74 g, 4 mmol) and 4-nitrobenzyl bromide (0.86 g, 4 mmol) in N,N-dimethylformamide (DMF, 5 mL). The reaction mixture was stirred at room temperature for 4 hours. After the reaction was completed, the product was extracted with ethyl acetate (50 mL) and the organic phase was washed with water (20 mL x 3). The organic layer was dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography using ethyl acetate as eluent to afford the target compound tert-butyl 4-(4-nitrobenzyl)-1-piperazinecarboxylate (3) (1.22 g, 95% yield) with a melting point of 99-100 °C. 1H NMR (DMSO-d6) data were as follows: δ 8.21-8.19 (d, 2H, J = 8.8 Hz, Ar-H), 7.61 -7.59 (d, 2H, J = 8.0 Hz, Ar-H), 3.63 (s, 2H, CH2), 3.34-3.30 (m, 4H, partially fuzzy, 2 × CH2), 2.35-2.32 (m, 4H, 2 × CH2), 1.39 (s, 9H, 3 × CH3). Elemental analysis (C16H23N3O4) results are consistent with calculated values.

References

[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 19, p. 5592 - 5599
[2] Patent: US2004/34033, 2004, A1. Location in patent: Page/Page column 12; Sheet 1
[3] Patent: US2007/249649, 2007, A1. Location in patent: Page/Page column 116
[4] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 120
[5] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 122

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 48 Germany 1 India 1 United Kingdom 5 United States 11 Global 66
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Nantong MYBio-pharm. Co., Ltd.
Tel
0513-85921823 18662920231
Fax
86-513-85012876
Email
sales@ntminyanmedical.com
Country
China
ProdList
4108
Advantage
58
Shanghai Kahn Pharmaceutical Co., Ltd.
Tel
021-34979681; 17701870669
Fax
021-34979681
Email
41513101@qq.com
Country
China
ProdList
1785
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Chengdu Xiaojia Technology Co., Ltd.
Tel
15902830537
Email
zhanghao@happysyn.com
Country
China
ProdList
3180
Advantage
55
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Yantai ShengKailun Chemical Technology Co., Ltd.
Tel
13356901049
Fax
QQ：1025383091
Email
3119594100@qq.com
Country
China
ProdList
7964
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
JinJin Le Chemical Co., Ltd
Tel
18001959627(微信同号) 18001959627
Email
jjlchem2@163.com
Country
China
ProdList
9981
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai ruichang pharmaceutical technology co., LTD
Tel
18621054990
Email
maychemicals@sina.com
Country
China
ProdList
673
Advantage
58
Shanghai UCHEM Inc.
Tel
+862156762820 +86-13564624040
Email
sales@myuchem.com
Country
China
ProdList
8460
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29798
Advantage
58
Nantong puyue biomedical Co., Ltd
Tel
0513-0513-0513-89158300 18014392889
Fax
0513-89158198
Email
sales@puyerbiopharma.com
Country
China
ProdList
4956
Advantage
58
Zhengzhou Alpha Chemical Co. LTD
Tel
0371-0371-53732842 13383863444
Fax
QQ：3002612166
Email
3002612166@qq.com
Country
China
ProdList
9996
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Shanghai Hanlin biology science and technology co., ltd
Tel
183-0212-4410 18302124410
Email
Djt18302124410@163.com
Country
China
ProdList
3000
Advantage
58
Shanghai Aizikang Pharmaceutical Research Co., Ltd
Tel
18721109360
Email
306685371@qq.com
Country
China
ProdList
1944
Advantage
58
Beijing Stronger Science Co., Ltd.
Tel
0531-88924771 15614660963
Email
elsa.hang@strongerscience.com
Country
China
ProdList
10623
Advantage
58
JinOu Biomedical (Nanjing) Co., Ltd.
Tel
13000000000
Fax
jinoupharma@163
Email
jinoupharma@163.com
Country
China
ProdList
11721
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Beijing InnoChem Science & Technology Co., Ltd.
Tel
15652467323
Email
sales@inno-chem.com.cn
Country
China
ProdList
8293
Advantage
58
Suzhou Highfine Biotech Co., Ltd
Tel
0512-69209928 18796809688
Email
zhouyingxiang@highfine.com
Country
China
ProdList
1356
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Yantai Sheng Kai Lun Biological Products Co. , Ltd.
Tel
13356901049
Email
mark@sklnchem.cn
Country
China
ProdList
7997
Advantage
58
Shanghai Haohong Scientific Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Beijing FYF Chemicals Co., Ltd
Tel
010-57903446 15869909019
Email
168931144@qq.com
Country
China
ProdList
4965
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50751
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Shanghai Zunlijia Life Technology Co., Ltd
Tel
021-34045219 13062664914
Email
huji@zunlijia.com
Country
China
ProdList
10027
Advantage
58
Wuhan WinYuanBei Trading Company
Tel
86-13349903920 13349903920
Fax
-
Email
869523959@qq.com
Country
China
ProdList
9627
Advantage
58
Sichuan Boyou Biotechnology Co., Ltd
Tel
028-65791793 18140026355
Email
568470422@qq.com
Country
China
ProdList
9459
Advantage
58
Aikon International Limited
Tel
025-58851090 13408877820
Email
2850281427@qq.com
Country
China
ProdList
10000
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
14580
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Jinan Yaode Biotechnology Co., Ltd
Tel
17805033575
Email
baiyu1.618@163.com
Country
China
ProdList
146
Advantage
58
Anyang Xiyan Technology Co., LTD
Tel
17525889330
Email
17525889330@163.com
Country
China
ProdList
7856
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
33024
Advantage
60
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49941
Advantage
58
PT CHEM GROUP LIMITED
Tel
+86-85511178;
Email
peter68@ptchemgroup.com
Country
China
ProdList
35425
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Suzhou Rovathin Foreign Trade Co.,Ltd
Tel
--
Fax
--
Email
sales@rovathin.com
Country
China
ProdList
4395
Advantage
58
Shanghai PI Chemicals Ltd.
Tel
--
Fax
--
Email
sales@pipharm.com
Country
China
ProdList
6344
Advantage
56
More
Less

View Lastest Price from 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co
Product
4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 130636-61-2
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-13

130636-61-2, 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

4-(4-NITRO-BENZYL)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER HYDROCHLORIDE 4-[CARBOXY-(4-NITRO-PHENYL)-METHYL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 4-(4-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

  • 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 4-[(4-NITROPHENYL)METHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
  • BUTTPARK 36\08-67
  • tert-butyl 4-[(4-nitrophenyl)Methyl]piperazine-1-carboxylate
  • 1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine
  • 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%
  • 1-Boc-4-(4-nitrobenzyl)piperazine
  • 4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylic acid tert-butyl ester
  • 1-Piperazinecarboxylic acid, 4-[(4-nitrophenyl)methyl]-, 1,1-dimethylethyl ester
  • N2-{[(2-Methyl-2-Propanyl)Oxy]Carbonyl}-L-Glutamine
  • tert-butyl 4-[(4-nitrophenyl)methyl]piperazine-1-carboxylate - [AC77724]
  • 130636-61-2
  • API intermediates