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4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name
4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.
130636-61-2
Chemical Name
4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms
BUTTPARK 36\08-67;1-Boc-4-(4-nitrobenzyl)piperazine;N2-{[(2-Methyl-2-Propanyl)Oxy]Carbonyl}-L-Glutamine;1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine;tert-butyl 4-[(4-nitrophenyl)Methyl]piperazine-1-carboxylate;4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%;4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylic acid tert-butyl ester;tert-butyl 4-[(4-nitrophenyl)methyl]piperazine-1-carboxylate - [AC77724];4-[(4-NITROPHENYL)METHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
CBNumber
CB4199461
Molecular Formula
C16H23N3O4
Formula Weight
321.37
MOL File
130636-61-2.mol
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4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Melting point:
99-100 °C
Boiling point:
436.5±40.0 °C(Predicted)
Density 
1.208±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
5.49±0.10(Predicted)
Appearance
White to light yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B656773
Product name
1-Boc-4-(4-Nitrobenzyl)piperazine
Packaging
250mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
071894
Product name
1-Boc-4-(4-Nitrobenzyl)piperazine
Purity
95+%
Packaging
1g
Price
$278
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0002708
Product name
4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity
95.00%
Packaging
250MG
Price
$187.95
Updated
2021/12/16
AK Scientific
Product number
X9773
Product name
1-Boc-4-(4-Nitrobenzyl)piperazine
Packaging
25g
Price
$717
Updated
2021/12/16
Matrix Scientific
Product number
071894
Product name
1-Boc-4-(4-Nitrobenzyl)piperazine
Purity
95+%
Packaging
5g
Price
$759
Updated
2021/12/16
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4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

100-11-8

57260-71-6

130636-61-2

General procedure for the synthesis of tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate from 4-nitrobenzyl bromide and N-BOC-piperazine: Potassium carbonate (3 g) was added to a solution containing tert-butyl 1-piperazinecarboxylate (0.74 g, 4 mmol) and 4-nitrobenzyl bromide (0.86 g, 4 mmol) in N,N-dimethylformamide (DMF, 5 mL). The reaction mixture was stirred at room temperature for 4 hours. After the reaction was completed, the product was extracted with ethyl acetate (50 mL) and the organic phase was washed with water (20 mL x 3). The organic layer was dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography using ethyl acetate as eluent to afford the target compound tert-butyl 4-(4-nitrobenzyl)-1-piperazinecarboxylate (3) (1.22 g, 95% yield) with a melting point of 99-100 °C. 1H NMR (DMSO-d6) data were as follows: δ 8.21-8.19 (d, 2H, J = 8.8 Hz, Ar-H), 7.61 -7.59 (d, 2H, J = 8.0 Hz, Ar-H), 3.63 (s, 2H, CH2), 3.34-3.30 (m, 4H, partially fuzzy, 2 × CH2), 2.35-2.32 (m, 4H, 2 × CH2), 1.39 (s, 9H, 3 × CH3). Elemental analysis (C16H23N3O4) results are consistent with calculated values.

References

[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 19, p. 5592 - 5599
[2] Patent: US2004/34033, 2004, A1. Location in patent: Page/Page column 12; Sheet 1
[3] Patent: US2007/249649, 2007, A1. Location in patent: Page/Page column 116
[4] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 120
[5] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 122

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 48 Germany 1 India 1 United Kingdom 5 United States 11 Global 66
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co
Product
4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 130636-61-2
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-13

130636-61-2, 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

4-(4-NITRO-BENZYL)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER HYDROCHLORIDE 4-[CARBOXY-(4-NITRO-PHENYL)-METHYL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 4-(4-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

  • 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 4-[(4-NITROPHENYL)METHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
  • BUTTPARK 36\08-67
  • tert-butyl 4-[(4-nitrophenyl)Methyl]piperazine-1-carboxylate
  • 1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine
  • 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%
  • 1-Boc-4-(4-nitrobenzyl)piperazine
  • 4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylic acid tert-butyl ester
  • 1-Piperazinecarboxylic acid, 4-[(4-nitrophenyl)methyl]-, 1,1-dimethylethyl ester
  • N2-{[(2-Methyl-2-Propanyl)Oxy]Carbonyl}-L-Glutamine
  • tert-butyl 4-[(4-nitrophenyl)methyl]piperazine-1-carboxylate - [AC77724]
  • 130636-61-2
  • API intermediates