2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

ChemicalBook > CAS DataBase List > 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

Product Name: 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
CAS No.: 304896-28-4
Chemical Name: 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Synonyms: AGK2;CS-2248;SIRT,AGK2;AGK2;AGK-2;AGK 2;SIRT2 Inhibitor, AGK2;AGK2, sirtuin2 (SIRT2) inhibitor;SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem;2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-(5-quinolyl)acrylamide;2-Cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide;2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
CBNumber: CB42101251
Molecular Formula: C23H13Cl2N3O2
Formula Weight: 434.27
MOL File: 304896-28-4.mol

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2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Property

Boiling point:: 675.1±55.0 °C(Predicted)
Density: 1.445±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble2mg/mL, clear (warmed)
form: Yellow solid
pka: 8.87±0.43(Predicted)
color: White to Yellow to Orange

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 2934.99.4400

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A8231
Product name: AGK2
Purity: ≥97% (HPLC), powder
Packaging: 5mg
Price: $158
Updated: 2024/03/01

Sigma-Aldrich

Product number: 566324
Product name: SIRT2 Inhibitor, AGK2
Packaging: 5mg
Price: $216
Updated: 2024/03/01

TCI Chemical

Product number: A3193
Product name: AGK-2
Purity: >97.0%(HPLC)
Packaging: 5mg
Price: $47
Updated: 2024/03/01

TCI Chemical

Product number: A3193
Product name: AGK-2
Purity: >97.0%(HPLC)
Packaging: 25mg
Price: $163
Updated: 2024/03/01

Cayman Chemical

Product number: 13145
Product name: AGK2
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Chemical Properties,Usage,Production

Uses

AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

Definition

ChEBI: 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-(5-quinolinyl)-2-propenamide is a member of quinolines.

Biological Activity

Selective inhibitor of SIRT2 (IC 50 = 3.5 μ M). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μ M. Reduces α -synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.

Biochem/physiol Actions

AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.

References

[1]. outeiro tf, kontopoulos e, altmann sm, et al. sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of parkinson's disease. science, 2007, 317(5837): 516-519.
[2]. scuderi c, stecca c, bronzuoli mr, et al. sirtuin modulators control reactive gliosis in an in vitro model of alzheimer's disease. front pharmacol, 2014, 5: 89.
[3]. rotili d, tarantino d, nebbioso a, et al. discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. j med chem, 2012, 55(24): 10937-10947.

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide manufacturers

Career Henan Chemical Co

Product: 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide 304896-28-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-02-18

Career Henan Chemical Co

Product: 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide 304896-28-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-02-18

304896-28-4, 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamideRelated Search:

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2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem

CS-2248

AGK2;AGK-2;AGK 2

AGK2

SIRT2 Inhibitor, AGK2

2-Cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide

2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide USP/EP/BP

SIRT,AGK2

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-(5-quinolyl)acrylamide

AGK2, sirtuin2 (SIRT2) inhibitor

304896-28-4

C23H13Cl2N3O2AgK2

C23H13Cl2N3O2

Inhibitors