ChemicalBook > CAS DataBase List > 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT

5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT

Product Name
5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT
CAS No.
1949-20-8
Chemical Name
5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT
Synonyms
OXOLAMINE CITRATE;AF-438 citrate;OxolaminCitrate;SKF-9976 citrate;CITRATO OXOLAMINA;CITRATE OXOLAMINE;Oxolamine Citric Acid;OXOLAMINE CITRATE SALT;Oxolamine citrate (SKF-9976;oxolamine dihydrogen citrate
CBNumber
CB4212634
Molecular Formula
C20H27N3O8
Formula Weight
437.44
MOL File
1949-20-8.mol
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5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Property

Melting point:
141-142 °C
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
color 
Crystals. Sltly sol in water and alc
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
RO0720000
Toxicity
TDLo orl-rat: 15 g/kg/1Y-I:CAR EMPSAL 2,1,63 orl-rat LD50:1650 mg/kg BJPCAL 16,209,61
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O2256
Product name
Oxolamine citrate salt
Packaging
25g
Price
$83.3
Updated
2024/03/01
Usbiological
Product number
165764
Product name
Oxolamine Citrate
Packaging
1g
Price
$319
Updated
2021/12/16
TRC
Product number
O857450
Product name
OxolamineCitrate
Packaging
25g
Price
$75
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008452
Product name
OXOLAMINE CITRATE SALT
Purity
95.00%
Packaging
10MG
Price
$400.02
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008452
Product name
OXOLAMINE CITRATE SALT
Purity
95.00%
Packaging
25G
Price
$469.6
Updated
2021/12/16
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5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Chemical Properties,Usage,Production

Originator

Bredon,Organon

Uses

Oxolamine Citrate, is a antiinflammatory drug used as a cough suppressant.

Manufacturing Process

18.7 g 3-chloro-propionyl chloride in 50 ml of dry ether was added dropwise with stirring to the cooled with ice solution 40 g of N-hydroxybenzamidine in 450 ml dry ester. A dense precipitate had fallen. The mixture was stirred 0.5 hour at room temperature and then was filtered off. The precipitate was thoroughly washed with water for a removal hydrochloride of starting Nhydroxybenzamidine whereas N-(amino)phenylmethylene-3-Cl-propionamide didnt solve. It was dried in vacuum over P2O5. Yield of clean product 94% from theoretical. MP: 98°-99°C. The solution of 9.2 g diethyl amine in 50 ml dry benzene was added dropwise to a suspension of above prepared N(amino)phenylmethylene-3-Cl-propionamide in dry benzene with stirring and cooling.
The mixture was warmed and stirred else 2 hours after adding. Then it was cooled, washed two times with water and dried over CaCl2. Then the solvent was removed. The residue was distilled in vacuum. Diethyl-[2-(3phenyl[1,2,4]oxadiasol-5)ethyl]amine (oxolamine) had BP: 127°C/0.4 mm. Yield 10.5 g.

Therapeutic Function

Antitussive, Antiinflammatory

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx. See also AMINES and other oxolamhe entries

5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Suppliers

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1949-20-8, 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALTRelated Search:


  • OXOLAMINE CITRATE
  • OXOLAMINE CITRATE SALT
  • 2,4-oxadiazole,5-(2-(diethylamino)ethyl)-3-phenyl-citrate
  • 3-phenyl-5-(beta-(diethylamino)ethyl)-1,2,4-oxadiazolecitrate
  • 5-beta-diethylaminoethyl-3-phenyl-1,2,4-oxadiazolecitrate
  • OxolaminCitrate
  • 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE
  • 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT
  • oxolamine dihydrogen citrate
  • Oxolamine Citric Acid
  • CITRATO OXOLAMINA
  • AF-438 citrate
  • SKF-9976 citrate
  • CITRATE OXOLAMINE
  • Oxolamine citrate (SKF-9976
  • Oxolamine Citric AcidQ: What is Oxolamine Citric Acid Q: What is the CAS Number of Oxolamine Citric Acid Q: What is the storage condition of Oxolamine Citric Acid Q: What are the applications of Oxolamine Citric Acid
  • inhibit,anti-inflammatory,SKF9976,respiratory,Oxolamine,AF 438,SKF 9976,SKF-9976,suppressant,cough,tract,Oxolamine citrate,AF-438,diseases,Inhibitor,AF438
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