5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT

ChemicalBook > CAS DataBase List > 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT

5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT

Product Name: 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT
CAS No.: 1949-20-8
Chemical Name: 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT
Synonyms: OXOLAMINE CITRATE;AF-438 citrate;OxolaminCitrate;SKF-9976 citrate;CITRATO OXOLAMINA;CITRATE OXOLAMINE;Oxolamine Citric Acid;OXOLAMINE CITRATE SALT;Oxolamine citrate (SKF-9976;oxolamine dihydrogen citrate
CBNumber: CB4212634
Molecular Formula: C20H27N3O8
Formula Weight: 437.44
MOL File: 1949-20-8.mol

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5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Property

Melting point:: 141-142 °C
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
color: Crystals. Sltly sol in water and alc

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: RO0720000
Toxicity: TDLo orl-rat: 15 g/kg/1Y-I:CAR EMPSAL 2,1,63 orl-rat LD50:1650 mg/kg BJPCAL 16,209,61

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O2256
Product name: Oxolamine citrate salt
Packaging: 25g
Price: $83.3
Updated: 2024/03/01

Usbiological

Product number: 165764
Product name: Oxolamine Citrate
Packaging: 1g
Price: $319
Updated: 2021/12/16

TRC

Product number: O857450
Product name: OxolamineCitrate
Packaging: 25g
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008452
Product name: OXOLAMINE CITRATE SALT
Purity: 95.00%
Packaging: 10MG
Price: $400.02
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008452
Product name: OXOLAMINE CITRATE SALT
Purity: 95.00%
Packaging: 25G
Price: $469.6
Updated: 2021/12/16

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5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Chemical Properties,Usage,Production

Originator

Bredon,Organon

Uses

Oxolamine Citrate, is a antiinflammatory drug used as a cough suppressant.

Manufacturing Process

18.7 g 3-chloro-propionyl chloride in 50 ml of dry ether was added dropwise with stirring to the cooled with ice solution 40 g of N-hydroxybenzamidine in 450 ml dry ester. A dense precipitate had fallen. The mixture was stirred 0.5 hour at room temperature and then was filtered off. The precipitate was thoroughly washed with water for a removal hydrochloride of starting Nhydroxybenzamidine whereas N-(amino)phenylmethylene-3-Cl-propionamide didnt solve. It was dried in vacuum over P2O5. Yield of clean product 94% from theoretical. MP: 98°-99°C. The solution of 9.2 g diethyl amine in 50 ml dry benzene was added dropwise to a suspension of above prepared N(amino)phenylmethylene-3-Cl-propionamide in dry benzene with stirring and cooling.
The mixture was warmed and stirred else 2 hours after adding. Then it was cooled, washed two times with water and dried over CaCl2. Then the solvent was removed. The residue was distilled in vacuum. Diethyl-[2-(3phenyl[1,2,4]oxadiasol-5)ethyl]amine (oxolamine) had BP: 127°C/0.4 mm. Yield 10.5 g.

Therapeutic Function

Antitussive, Antiinflammatory

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx. See also AMINES and other oxolamhe entries

5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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1949-20-8, 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALTRelated Search:

Oxolamine Sodium citrate Citric acid Omeprazole 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT 3,5-DIMETHYL-1,2,4-OXADIAZOLE 2-(3-PHENYL-[1,2,4]OXADIAZOL-5-YL)-ETHYLAMINE Ammonium citrate tribasic Ammonium citrate dibasic 5-METHYL-3-PHENYL-1,2,4-OXADIAZOLE

OXOLAMINE CITRATE

OXOLAMINE CITRATE SALT

2,4-oxadiazole,5-(2-(diethylamino)ethyl)-3-phenyl-citrate

3-phenyl-5-(beta-(diethylamino)ethyl)-1,2,4-oxadiazolecitrate

5-beta-diethylaminoethyl-3-phenyl-1,2,4-oxadiazolecitrate

OxolaminCitrate

5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE

5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT

oxolamine dihydrogen citrate

Oxolamine Citric Acid

CITRATO OXOLAMINA

AF-438 citrate

SKF-9976 citrate

CITRATE OXOLAMINE

Oxolamine citrate (SKF-9976

Oxolamine Citric AcidQ: What is Oxolamine Citric Acid Q: What is the CAS Number of Oxolamine Citric Acid Q: What is the storage condition of Oxolamine Citric Acid Q: What are the applications of Oxolamine Citric Acid

inhibit,anti-inflammatory,SKF9976,respiratory,Oxolamine,AF 438,SKF 9976,SKF-9976,suppressant,cough,tract,Oxolamine citrate,AF-438,diseases,Inhibitor,AF438

1949-20-8

C14H19N3OC6H8O7

C14H19N3OC6H78O7

Building Blocks

Amino Alcohols

Oxygen Compounds

Organic Building Blocks