Oxolamine
- Product Name
- Oxolamine
- CAS No.
- 959-14-8
- Chemical Name
- Oxolamine
- Synonyms
- 683M;683 M;Bredon;AF-438;OXOLAMINE;Ossolamina;BRN 0527181;Oxolamine (base and/or unspecified salts);5-[2-(diethylamino)ethyl]-3-phenyl-1,2,4-oxadiazole;1,2,4-OXADIAZOLE,5-(2-DIETHYLAMINO)ETHYL)-3-PHENYL-
- CBNumber
- CB5491924
- Molecular Formula
- C14H19N3O
- Formula Weight
- 245.32
- MOL File
- 959-14-8.mol
Oxolamine Property
- Melting point:
- 25°C
- Boiling point:
- bp0.4 127°
- Density
- 1.0516 (rough estimate)
- refractive index
- 1.5310 (estimate)
- pka
- 9.40±0.25(Predicted)
- form
- Liquid
- LogP
- 2.393
- CAS DataBase Reference
- 959-14-8(CAS DataBase Reference)
Safety
- Toxicity
- LD50 oral in rat: > 2gm/kg
Oxolamine Chemical Properties,Usage,Production
Originator
Bredon,Organon
Uses
Oxolamine is a antiinflammatory drug used as a cough suppressant.
Definition
ChEBI: N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine is an oxadiazole and a ring assembly.
Manufacturing Process
18.7 g 3-chloro-propionyl chloride in 50 ml of dry ether was added dropwise with stirring to the cooled with ice solution 40 g of N-hydroxybenzamidine in 450 ml dry ester. A dense precipitate had fallen. The mixture was stirred 0.5 hour at room temperature and then was filtered off. The precipitate was thoroughly washed with water for a removal hydrochloride of starting Nhydroxybenzamidine whereas N-(amino)phenylmethylene-3-Cl-propionamide didnt solve. It was dried in vacuum over P2O5. Yield of clean product 94% from theoretical. MP: 98°-99°C. The solution of 9.2 g diethyl amine in 50 ml dry benzene was added dropwise to a suspension of above prepared N(amino)phenylmethylene-3-Cl-propionamide in dry benzene with stirring and cooling.
The mixture was warmed and stirred else 2 hours after adding. Then it was cooled, washed two times with water and dried over CaCl2. Then the solvent was removed. The residue was distilled in vacuum. Diethyl-[2-(3phenyl[1,2,4]oxadiasol-5)ethyl]amine (oxolamine) had BP: 127°C/0.4 mm. Yield 10.5 g.
Therapeutic Function
Antitussive, Antiinflammatory
Safety Profile
Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
Oxolamine Preparation Products And Raw materials
Raw materials
Preparation Products
Oxolamine Suppliers
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7815
- Advantage
- 57
- Tel
- 0510-86010668
- Fax
- 0510-86010668
- sales@biopharmamatrix.com
- Country
- China
- ProdList
- 3354
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 029-87576359 17691182729
- Fax
- 029-88380327
- 1018@dideu.com
- Country
- China
- ProdList
- 1982
- Advantage
- 58
- Tel
- 021-50676523 18019098996
- info@acelybio.com
- Country
- China
- ProdList
- 3967
- Advantage
- 58
- Tel
- +8613288715578
- sales@hbmojin.com
- Country
- China
- ProdList
- 12453
- Advantage
- 58
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19892
- Advantage
- 58
- Tel
- 029-89275612 +8618991951683
- Fax
- 8618991951683
- mcbio_sales@163.com
- Country
- China
- ProdList
- 2255
- Advantage
- 58
- Tel
- 0551-65418671
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34572
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30255
- Advantage
- 58
View Lastest Price from Oxolamine manufacturers
- Product
- Oxolamine 959-14-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-01
- Product
- Oxolamine 959-14-8
- Price
- US $1.00/PCS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-05-31