ChemicalBook > CAS DataBase List > 5-methyl-1H-pyrazole-3-carbaldehyde
5-methyl-1H-pyrazole-3-carbaldehyde
- Product Name
- 5-methyl-1H-pyrazole-3-carbaldehyde
- CAS No.
- 3273-44-7
- Chemical Name
- 5-methyl-1H-pyrazole-3-carbaldehyde
- Synonyms
- 5-Methyl-3-forMylpyrazole;3-ForMyl-5-Methylpyrazole;5-Methylpyrazole-3-carbaldehyde;5-methyl-1H-pyrazole-3-carbaldehyde;5-Methyl-1H-pyrazole-3-carboxaldehyde;1H-Pyrazole-3-carboxaldehyde, 5-methyl-;5-methyl-1H-pyrazole-3-carbaldehyde(SALTDATA: FREE);3-methyl-1H-pyrazole-5-carbaldehyde(SALTDATA: FREE)
- CBNumber
- CB42134059
- Molecular Formula
- C5H6N2O
- Formula Weight
- 110.11
- MOL File
- 3273-44-7.mol
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5-methyl-1H-pyrazole-3-carbaldehyde Property
- Melting point:
- 190 °C
- Boiling point:
- 294.2±20.0 °C(Predicted)
- Density
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 11.76±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
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Safety
- RIDADR
- UN2811
- HazardClass
- IRRITANT
- HS Code
- 2933199090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
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N-Bromosuccinimide Price
TRC
- Product number
- M336415
- Product name
- 5-Methyl-1H-pyrazole-3-carbaldehyde
- Packaging
- 500mg
- Price
- $240
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR925890
- Product name
- 5-Methyl-1H-pyrazole-3-carbaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $355
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 016461
- Product name
- 3-Methyl-1H-pyrazole-5-carbaldehyde
- Packaging
- 2.500g
- Price
- $573
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 016461
- Product name
- 3-Methyl-1H-pyrazole-5-carbaldehyde
- Packaging
- 500mg
- Price
- $144
- Updated
- 2021/12/16
Chemenu
- Product number
- CM112608
- Product name
- 5-methyl-1H-pyrazole-3-carbaldehyde
- Purity
- 95+%
- Packaging
- 10g
- Price
- $739
- Updated
- 2021/12/16
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5-methyl-1H-pyrazole-3-carbaldehyde Chemical Properties,Usage,Production
Synthesis
4027-57-0
3273-44-7
General procedure for the synthesis of 5-methyl-1H-pyrazole-3-carbaldehyde from ethyl 3-methylpyrazole-5-carboxylate: 3-ethoxycarbonyl-5-methylpyrazole (1.0 g, 4.34 mmol) was dissolved in 15 ml of purified toluene under the protection of nitrogen, diisobutylaluminum hydride (DIBAL, 8.68 ml, 8.62 mmol) was added slowly and the reaction was carried out at -78 C. The reaction was stirred. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio hexane: ethyl acetate = 6:1). Upon completion of the reaction, the reaction was quenched by slow addition of methanol and water and the resulting mixture was filtered through a bed of diatomaceous earth and the aqueous layer was extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The concentrate was purified by column chromatography (eluent ratio of hexane: ethyl acetate: dichloromethane = 3:1:1) to afford the target product 5-methyl-1H-pyrazole-3-carbaldehyde in 82.4% yield. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 9.92 (s, 1H), 6.68 (s, 1H), 2.82 (s, 3H).
References
[1] Patent: EP1757590, 2007, A1. Location in patent: Page/Page column 5
[2] Patent: US2007/49604, 2007, A1. Location in patent: Page/Page column 3
5-methyl-1H-pyrazole-3-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-methyl-1H-pyrazole-3-carbaldehyde manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 5-methyl-1H-pyrazole-3-carbaldehyde 3273-44-7
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
Shaanxi Dideu Medichem Co. Ltd
- Product
- 5-Methyl-1H-pyrazole-3-carbaldehyde 3273-44-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-11
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