ChemicalBook > CAS DataBase List > 4-PHENYL-1,2,3-THIADIAZOLE

4-PHENYL-1,2,3-THIADIAZOLE

Product Name
4-PHENYL-1,2,3-THIADIAZOLE
CAS No.
25445-77-6
Chemical Name
4-PHENYL-1,2,3-THIADIAZOLE
Synonyms
BUTTPARK 91\16-70;4-phenylthiadiazole;4-PHENYL-1,2,3-THIADIAZOLE;1,2,3-Thiadiazole, 4-phenyl-;4-Phenyl-1,2,3-thiadiazole ,98%
CBNumber
CB4213954
Molecular Formula
C8H6N2S
Formula Weight
162.21
MOL File
25445-77-6.mol
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4-PHENYL-1,2,3-THIADIAZOLE Property

Melting point:
78°C
Boiling point:
100°C 1,5mm
Density 
1.241±0.06 g/cm3(Predicted)
Flash point:
100°C/1.5mm
storage temp. 
Store at -20°C
solubility 
DMF: 3 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form 
A crystalline solid
pka
-4.23±0.22(Predicted)
BRN 
119480
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Safety

Hazard Codes 
Xi
Safety Statements 
22-24/25
HazardClass 
IRRITANT
HS Code 
29420000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S541524
Product name
4-PHENYL-1,2,3-THIADIAZOLE
Purity
Aldrich
Packaging
250mg
Price
$29.8
Updated
2024/03/01
Alfa Aesar
Product number
L20197
Product name
4-Phenyl-1,2,3-thiadiazole
Packaging
1g
Price
$109
Updated
2021/12/16
Alfa Aesar
Product number
L20197
Product name
4-Phenyl-1,2,3-thiadiazole
Packaging
5g
Price
$416
Updated
2021/12/16
Alfa Aesar
Product number
L20197
Product name
4-Phenyl-1,2,3-thiadiazole
Packaging
250mg
Price
$43.2
Updated
2021/12/16
Cayman Chemical
Product number
10011055
Product name
4-phenyl-1,2,3-Thiadiazole
Packaging
100mg
Price
$31
Updated
2023/06/20
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4-PHENYL-1,2,3-THIADIAZOLE Chemical Properties,Usage,Production

Description

Cytochrome P450 (CYP450) enzymes are a superfamily of oxidative catalysts important in the biosynthesis and metabolism of a wide range of endogenous molecules as well as the metabolism of xenobiotics. For example, CYP2B4 metabolizes substituted amines, CYP2E1 metabolizes various alcohols and halogenated alkenes, and CYP1A2 catalyzes the oxygenation of aromatic compounds and polycyclic hydrocarbons. 4-phenyl-1,2,3-Thiadiazole is, at 100 μM, a selective inhibitor of certain CYP450 enzymes (CYP2B4, CYP2E1), but not others (CYP1A2), with inactivation occurring in a mechanism-based manner. 1,2,3-Thiadiazole compounds and their derivatives, including 4-phenyl-1,2,3-thiadiazole, are also commonly used as fungicides, herbicides, and plant growth regulators.

Chemical Properties

Off-white to light brown solid

Synthesis Reference(s)

Journal of Medicinal Chemistry, 28, p. 442, 1985 DOI: 10.1021/jm00382a009

4-PHENYL-1,2,3-THIADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-PHENYL-1,2,3-THIADIAZOLE Suppliers

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