DIHYDROERGOTAMINE MESYLATE

Product Name: DIHYDROERGOTAMINE MESYLATE
CAS No.: 6190-39-2
Chemical Name: DIHYDROERGOTAMINE MESYLATE
Synonyms: Agit;detms;dhe45;DET MS;MT 300;DHE-45;Diergo;Ergont;Ikaran;Morena
CBNumber: CB4221630
Molecular Formula: C33H37N5O5.CH4O3S
Formula Weight: 679.79
MOL File: 6190-39-2.mol

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DIHYDROERGOTAMINE MESYLATE Property

Melting point:: 232°C
refractive index: -20 ° (C=0.25, JP Method)
storage temp.: Store at RT
solubility: methanol: 21 mg/mL
form: powder
color: white
Merck: 14,3174
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference: 6190-39-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
RIDADR: 1544
WGK Germany: 3
RTECS: KE7920000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2939690000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D1950000
Product name: Dihydroergotamine mesilate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: d1950000
Price: $153
Updated: 2024/03/01

TCI Chemical

Product number: D2633
Product name: Dihydroergotamine Mesylate
Purity: >97.0%(HPLC)
Packaging: 100mg
Price: $85
Updated: 2024/03/01

TCI Chemical

Product number: D2633
Product name: Dihydroergotamine Mesylate
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $311
Updated: 2024/03/01

Alfa Aesar

Product number: J63840
Product name: Dihydroergotamine methanesulfonate
Packaging: 1g
Price: $444.65
Updated: 2024/03/01

Alfa Aesar

Product number: J63840
Product name: Dihydroergotamine methanesulfonate
Packaging: 100mg
Price: $88.3
Updated: 2023/06/20

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DIHYDROERGOTAMINE MESYLATE Chemical Properties,Usage,Production

Description

Dihydroergotamine mesylate (6190-39-2) is a full agonist at serotonin 5HT1B and 5HT1D receptors, IC50= 2 and 2.2 nM respectively1 and also at 5HT1A and 5HT1F receptors2. One of the oldest agents for treatment of migraine.3 Also acts as a potent vasoconstrictor and alpha-adrenergic antagonist.4

Chemical Properties

White to Off-White Solid

Uses

α-Androgenic blocker with selective venoconstrictor properties. Also binds to serotonin 5HT1-receptors. Antimigraine.

Uses

vasoconstrictor, antimigraine

Uses

Agonist at vascular serotonin receptors; partial agonist at alpha-adrenergic and dopamine D2 receptors

Definition

ChEBI: The methanesulfonic acid salt of dihydroergotamine, a semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine. Both the mesylate and the tartrate salts are used for the treatment of migraine and orthostatic hypotens on.

brand name

D.H.E. 45 (Valeant); Migranal (Valeant) .

Biological Activity

Partial α -adrenergic agonist. Partial D 2 dopaminergic receptor agonist. Competitive 5-HT antagonist.

storage

Room temperature

References

Lesage et al. (1998), Agnostic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines; J. Pharmacol., 123 1655 Silberstein (1997), The pharmacology of ergotamine and dihydroergotamine; Headache, 37 Suppl 1 S15 Silberstein and McCrory (2003), Ergotamine and dihydroergotamine: history, pharmacology, and efficacy; Headache, 43 144 Lipton (1997), Ergotamine tartrate and dihydroergotamine mesylate: safety profiles; Headache, 37 Suppl.1 S33

DIHYDROERGOTAMINE MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DIHYDROERGOTAMINE MESYLATE manufacturers

Career Henan Chemical Co

Product: DIHYDROERGOTAMINE MESYLATE 6190-39-2
Price: US $1.00-2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,10kg,100kg
Release date: 2019-08-07

6190-39-2, DIHYDROERGOTAMINE MESYLATERelated Search:

Rapamycin Tacrolimus Zafirlukast Sunitinib Malate Dihydroergotoxine mesylate DIHYDROERGOTAMINE ergotamine DIHYDROERGOTAMINE MESYLATE Dihydroergotamine Mesylate USP,BP,JP,Eur,Ph

5'-Benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman

9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trionemonomethanesulfonate

9,10-dihydroergotaminemesylate

9,10-dihydro-ergotaminmonomethanesulfonate(salt)

Agit

Angionorm

D.H.E. 45

Dergotamine

DET MS

detms

Dihydroergotamine Mesylate (250 mg) (List Chemical)

MT 300

Dihydroergotamine Mesylate (250 mg)

ZOZUFVUTVAZUDP-OESQIVJBSA-N

Dihydroergotamine Mesylate (500 mg)

(5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-Methyl-5'-(phenylMethyl)ergotaMan-3',6',18-trione

dhe45

DHE-45

Diergo

Dihydergot

Dihydroergotamine monomethanesulfonate

dihydroergotaminemesilate

Dirgotarl

Endophleban

Ergomimet

Ergont

Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha,10alpha)-, monomethanesulfonate

Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, monomethanesulfonate (salt)

Ergotonin

Ikaran

Migranal

Morena

Orstanorm

Tonopres

Verladyn

9,10-DIHYDRO-12'-HYDROXY-2'-METHYL-5'-(PHENYLMETHYL)ERGOTAMAN-3',6',18-TRIONE MESYLATE

DIHYDROERGOTAMINE MESYLATE

DIHYDROERGOTAMINE METHANESULFONATE

DIHYDROERGOTAMINE METHANESULFONATE SALT

Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-methyl-5'-(phenylmethyl)-, (5'α,10α)-, monomethanesulfonate (salt)

DIHYDROERGOTAMINEMESYLATE,USP

Dihydroergocristine Mesilate Impurity 5（Dihydroergocristine Mesilate EP Impurity E）

Dihydroergotamine for peak identification CRS

Dihydroergotamine mesilate CRS

(6aR,9R,10aR)-N-((2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide methanesulfonate

DIHYDROERGOTAMINE MESYLATE USP/EP/BP

Dihydroergotamine Mesylate (1.0mg/ml in DMSO)

Dihydroergotamine for peak identification (Y0000831)

Dihydroergotamine mesilate (D1950000)

Dihydroergotamine Mesylate (1202005)

Dihydroergotamine Mesylate (DHE

Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-methyl-5'-(phenylmethyl)-, (5',10)-, monomethanesulfonate (salt)

Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)-, (5′α,10α)-, methanesulfonate (1:1)

6190-39-2

C34H41N5O8S

C33H37N5O5CH3SO3H

C33H37N5O5CH4O3S

MIGRANAL