ChemicalBook > CAS DataBase List > MORPHOLINE-4-SULFONYL CHLORIDE

MORPHOLINE-4-SULFONYL CHLORIDE

Product Name: MORPHOLINE-4-SULFONYL CHLORIDE
CAS No.: 1828-66-6
Chemical Name: MORPHOLINE-4-SULFONYL CHLORIDE
Synonyms: Albb-005583;Morpholinosulfonyl chloride;4-MORPHOLINESULFONYL CHLORIDE;MORPHOLINE-4-SULFONYL CHLORIDE;MORPHOLINE-4-SULFONYL CHLORIDE ISO 9001：2015 REACH
CBNumber: CB4227379
Molecular Formula: C4H8ClNO3S
Formula Weight: 185.63
MOL File: 1828-66-6.mol

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MORPHOLINE-4-SULFONYL CHLORIDE Property

Melting point:: 72.36° C (Predicted)
Boiling point:: 300℃
Density: 1.53
Flash point:: 135℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -10.95±0.20(Predicted)
form: Solid or Liquid
color: Colorless or White to Yellow
InChI: InChI=1S/C4H8ClNO3S/c5-10(7,8)6-1-3-9-4-2-6/h1-4H2
InChIKey: KXIBCCFSAMRWIC-UHFFFAOYSA-N
SMILES: N1(S(Cl)(=O)=O)CCOCC1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
RIDADR: UN3265
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: M723915
Product name: Morpholine-4-sulfonylChloride
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: Z4320
Product name: Morpholine-4-sulfonylchloride
Packaging: 4x25g
Price: $527
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0030865
Product name: MORPHOLINE-4-SULFONYL CHLORIDE
Purity: 95.00%
Packaging: 2.5G
Price: $1227.82
Updated: 2021/12/16

Matrix Scientific

Product number: 021511
Product name: Morpholine-4-sulfonyl chloride
Purity: 95%
Packaging: 1g
Price: $14
Updated: 2021/12/16

Matrix Scientific

Product number: 021511
Product name: Morpholine-4-sulfonyl chloride
Purity: 95%
Packaging: 5g
Price: $34
Updated: 2021/12/16

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MORPHOLINE-4-SULFONYL CHLORIDE Chemical Properties,Usage,Production

Uses

Morpholine-4-sulfonyl chloride is used as an intermediate in organic synthesis for the preparation of benzothiazole compounds or thiazolecarboxamide derivatives and other organic heterocyclic compounds.

Synthesis

110-91-8

1828-66-6

1. 10.0 mL of dichloromethane (CH2Cl2) was added to a 50 mL round bottom flask and cooled in an ice bath. 2. 0.300 mL of sulfuryl chloride (SO2Cl2) was slowly added to the cooled dichloromethane. 3. 213 mg of morpholine was dissolved in 3.0 mL of dichloromethane and slowly added to the above reaction mixture, kept cool in an ice bath. 4. 520 mg of trimethylamine was added and the reaction mixture was stirred at room temperature for about 2 hours. 5. Upon completion of the reaction, the product was dissolved with 20.0 mL of chloroform and subsequently washed with 20.0 mL of ice water. 6. The chloroform phase was separated, dried over magnesium sulfate (MgSO4) and filtered. 7. The filtrate was distilled under pressure to give 160 mg of morpholine-4-sulfonyl chloride in about 23.3% yield. 8. 70.0 mg of (R)-N-methyl-N-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine was added to a 5 mL round-bottomed flask and dissolved in 1.00 mL of dichloromethane. 9. 0.0390 mL morpholine-4-sulfonyl chloride was added, followed by 0.0590 mL N,N-diisopropylethylamine and stirred overnight at room temperature. 10. The reaction mixture was concentrated under pressure and the residue was purified by fast column chromatography (MeOH:CH2Cl2 = 2:98). 11. The purified grades were collected, concentrated under reduced pressure and further dried under vacuum to give 47.0 mg (R)-N-methyl-N-(1-(morpholinosulfonyl)pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine in about 40.2% yield. 12. The product was analyzed by 1H NMR. 12. The product was structurally confirmed by 1H NMR and LRMS (ESI).

References

[1] Patent: WO2005/117904, 2005, A2. Location in patent: Page/Page column 463-464
[2] Patent: US5587388, 1996, A
[3] Patent: EP601486, 1994, A1
[4] Patent: US2006/223759, 2006, A1. Location in patent: Page/Page column 218
[5] Justus Liebigs Annalen der Chemie, 1959, vol. 624, p. 25,29

MORPHOLINE-4-SULFONYL CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MORPHOLINE-4-SULFONYL CHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Morpholine-4-sulfonyl chloride 1828-66-6
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-06

Career Henan Chemical Co

Product: MORPHOLINE-4-SULFONYL CHLORIDE 1828-66-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-23

1828-66-6, MORPHOLINE-4-SULFONYL CHLORIDERelated Search:

Morpholine-2-carbonitrile hydrochloride Methyl Morpholine-3-carboxylate-HCl 2-Morpholinecarboxylicacid,methylester(9CI) methyl morpholine-2-carboxylate hydrochloride MORFOLINE METHYLCARBAMATE Nifedipine 4-Chlorosulfonylimidazole 1-N-BOC-MORPHOLINE Dimethylsulfamoyl chloride METHYLSULFAMOYL CHLORIDE 2-methylmorpholine-4-sulfonyl chloride DIETHYLSULFAMOYL CHLORIDE 2,6-DIMETHYLMORPHOLINE-4-SULFONYL CHLORIDE MORPHOLINE-4-SULFONYL CHLORIDE

4-MORPHOLINESULFONYL CHLORIDE

MORPHOLINE-4-SULFONYL CHLORIDE

Albb-005583

Morpholinosulfonyl chloride

MORPHOLINE-4-SULFONYL CHLORIDE ISO 9001：2015 REACH

1828-66-6

C4H8ClNO3S