Pyridomycin

Product Name: Pyridomycin
CAS No.: 18791-21-4
Chemical Name: Pyridomycin
Synonyms: Pyridomycin;3-Hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridylmethyl)-1,4-dioxa-8-azacyclododeca-6-yl]-2-pyridinecarboxamide;2-Pyridinecarboxamide, 3-hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridinylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]-
CBNumber: CB42282882
Molecular Formula: C27H32N4O8
Formula Weight: 540.57
MOL File: 18791-21-4.mol

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Pyridomycin Property

Melting point:: 222°
Boiling point:: 616.01°C (rough estimate)
Density: 1.3105 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Store at -20°C
solubility: DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
pka: 11.54±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17095
Product name: Pyridomycin
Purity: ≥95%
Packaging: 500μg
Price: $364
Updated: 2024/03/01

Cayman Chemical

Product number: 17095
Product name: Pyridomycin
Purity: ≥95%
Packaging: 2.5mg
Price: $1181
Updated: 2024/03/01

TRC

Product number: P997218
Product name: Pyridomycin
Packaging: 500μg
Price: $245
Updated: 2021/12/16

TRC

Product number: P997218
Product name: Pyridomycin
Packaging: 1000μg
Price: $395
Updated: 2021/12/16

Adipogen Life Sciences

Product number: BVT-0455-M001
Product name: Pyridomycin
Purity: ≥98%(1H-NMR,HPLC)
Packaging: 1mg
Price: $290
Updated: 2021/12/16

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Pyridomycin Chemical Properties,Usage,Production

Description

Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg/ml).

Uses

Pyridomycin is a potent antibiotic active against mycobacteria and some Gram negative bacteria, originally isolated from Streptomyces abidoflavus by Umezawa group at the NIH Japan in 1953, and since isolated from different species and published under several names. The unusual 12-membered macrocyclic depsipeptide comprises three unique sub-units incorporating two substituted pyridines. Pyridomycin is thought to target NADH-dependent enoyl (acyl-carrier-protein) reductase InhA. Recent reports of activity against isoniazid-resistant mycobacteria has seen pyridomycin identified as a potential lead for new generation antibiotics.

Uses

Pyridomycin is a potent antibiotic active against mycobacteria.

Pyridomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyridomycin Suppliers

China 27 India 1 United Kingdom 1 United States 3 Global 32

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
Advantage: 58

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

18791-21-4, PyridomycinRelated Search:

Clindamycin Azithromycin Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Daptomycin Gentamicin

3-Hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridylmethyl)-1,4-dioxa-8-azacyclododeca-6-yl]-2-pyridinecarboxamide

Pyridomycin

2-Pyridinecarboxamide, 3-hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridinylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]-

18791-21-4

C27H32N4O8