ChemicalBook > CAS DataBase List > (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

Product Name
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
CAS No.
56715-13-0
Chemical Name
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
Synonyms
(+)-Atenolol;(R)-(+)-ATENOLOL;Atenolol R-Isomer;(R)-(+)-AtenololHCl;(R)-(+)-Atenolol 99%;R(+)-ATENOLOL LESS ACTIVE ENANTIOME;Atenolol Impurity 15 ((R)-Atenolol);(R)-2-(4-(2-hydroxy-3-(isopropylaMino)propoxy)phenyl)acetaMide;2-[4-[(2R)-2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide;2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
CBNumber
CB4230500
Molecular Formula
C14H22N2O3
Formula Weight
266.34
MOL File
56715-13-0.mol
More
Less

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Property

Melting point:
148-152 °C(lit.)
Boiling point:
508.0±50.0 °C(Predicted)
Density 
1.125±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >6.0 mg/mL
form 
solid
pka
13.88±0.20(Predicted)
color 
pale yellow
optical activity
[α]25/D +16°, c = 1 in 1 M HCl
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
330884
Product name
(R)-(+)-Atenolol
Purity
99%
Packaging
100mg
Price
$160
Updated
2024/03/01
Cayman Chemical
Product number
18623
Product name
(R)-(+)-Atenolol
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18623
Product name
(R)-(+)-Atenolol
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
18623
Product name
(R)-(+)-Atenolol
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
18623
Product name
(R)-(+)-Atenolol
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
More
Less

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Chemical Properties,Usage,Production

Description

(+)-Atenolol is an enantiomer of the β1-adrenergic receptor (β1-AR) antagonist (±)-atenolol . (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (Ki = 8.61 μM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats.

Uses

Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).

Uses

Antihypertensor

Uses

less active enantiomer

Definition

ChEBI: The (R)-enantiomer of atenolol.

References

[1] stoschitzky k, egginger g, zernig g, et al. stereoselective features of (r)- and (s)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[j]. chirality, 1993, 5(1): 15-19.

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80

56715-13-0, (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDERelated Search:


  • (R)-(+)-AtenololHCl
  • 4-[(R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
  • 2-[4-[(2R)-2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide
  • 2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
  • 2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethanamide
  • (R)-(+)-Atenolol,(+)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
  • R(+)-ATENOLOL LESS ACTIVE ENANTIOME
  • Benzeneacetamide, 4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
  • Benzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, (R)-
  • (R)-(+)-ATENOLOL
  • 4-[(2R)-2-Hydroxy-3-[(1-Methylethyl)aMino]propoxy]benzeneacetaMide
  • (R)-2-(4-(2-hydroxy-3-(isopropylaMino)propoxy)phenyl)acetaMide
  • Atenolol R-Isomer
  • (R)-(+)-Atenolol 99%
  • (+)-2-[4-[(2R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy] phenyl] acetamide
  • (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
  • (+)-Atenolol
  • Atenolol Impurity 15 ((R)-Atenolol)
  • Prenormin,2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
  • 56715-13-0
  • CH32CHNHCH2CHOHCH2OC6H4CH2CONH2
  • Organic Building Blocks
  • Amino Alcohols
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals