ChemicalBook > CAS DataBase List > (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE

Product Name
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
CAS No.
56715-13-0
Chemical Name
(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
Synonyms
(+)-Atenolol;(R)-(+)-ATENOLOL;Atenolol R-Isomer;(R)-(+)-AtenololHCl;(R)-(+)-Atenolol 99%;R(+)-ATENOLOL LESS ACTIVE ENANTIOME;Atenolol Impurity 15 ((R)-Atenolol);(R)-2-(4-(2-hydroxy-3-(isopropylaMino)propoxy)phenyl)acetaMide;2-[4-[(2R)-2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide;2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
CBNumber
CB4230500
Molecular Formula
C14H22N2O3
Formula Weight
266.34
MOL File
56715-13-0.mol
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(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Property

Melting point:
148-152 °C(lit.)
Boiling point:
508.0±50.0 °C(Predicted)
Density 
1.125±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >6.0 mg/mL
form 
solid
pka
13.88±0.20(Predicted)
color 
pale yellow
optical activity
[α]25/D +16°, c = 1 in 1 M HCl
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
330884
Product name
(R)-(+)-Atenolol
Purity
99%
Packaging
100mg
Price
$160
Updated
2024/03/01
Cayman Chemical
Product number
18623
Product name
(R)-(+)-Atenolol
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18623
Product name
(R)-(+)-Atenolol
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
18623
Product name
(R)-(+)-Atenolol
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
18623
Product name
(R)-(+)-Atenolol
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
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(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Chemical Properties,Usage,Production

Description

(+)-Atenolol is an enantiomer of the β1-adrenergic receptor (β1-AR) antagonist (±)-atenolol . (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (Ki = 8.61 μM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats.

Uses

Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).

Uses

Antihypertensor

Uses

less active enantiomer

Definition

ChEBI: The (R)-enantiomer of atenolol.

References

[1] stoschitzky k, egginger g, zernig g, et al. stereoselective features of (r)- and (s)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[j]. chirality, 1993, 5(1): 15-19.

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Suppliers

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56715-13-0, (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDERelated Search:

S(-)-ATENOLOL (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Atenolol 4-Hydroxyphenylacetamide 4-METHOXYPHENYLACETAMIDE 1-AMINO-3-PHENOXY-PROPAN-2-OL 3-(4-methylphenoxy)propan-1-amine CHEMBRDG-BB 5482082 (2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL AKOS BC-1949 4-(3-Amino-2-hydroxypropoxy)phenylacetamide 3-(ISOPROPYLAMINO)-1,2-PROPANEDIOL 1-AMINO-3-(4-ETHYLPHENOXY)PROPAN-2-OL (R)-3-ISOPROPYLAMINO-1,2-PROPANEDIOL 1-METHYLAMINO-3-PHENOXY-PROPAN-2-OL CHEMBRDG-BB 9070877 ATENOLOL IMPURITY STANDARD

  • (R)-(+)-AtenololHCl
  • 4-[(R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
  • 2-[4-[(2R)-2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide
  • 2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
  • 2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethanamide
  • (R)-(+)-Atenolol,(+)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
  • R(+)-ATENOLOL LESS ACTIVE ENANTIOME
  • Benzeneacetamide, 4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
  • Benzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, (R)-
  • (R)-(+)-ATENOLOL
  • 4-[(2R)-2-Hydroxy-3-[(1-Methylethyl)aMino]propoxy]benzeneacetaMide
  • (R)-2-(4-(2-hydroxy-3-(isopropylaMino)propoxy)phenyl)acetaMide
  • Atenolol R-Isomer
  • (R)-(+)-Atenolol 99%
  • (+)-2-[4-[(2R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy] phenyl] acetamide
  • (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
  • (+)-Atenolol
  • Atenolol Impurity 15 ((R)-Atenolol)
  • Prenormin,2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
  • 56715-13-0
  • CH32CHNHCH2CHOHCH2OC6H4CH2CONH2
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