Nimustine

Product Name: Nimustine
CAS No.: 42471-28-3
Chemical Name: Nimustine
Synonyms: ACNU;ACNU 50;Nimustin;NIMUSTINE;NITROSOUREA;NIFUMICACID;NIMUSTINE HCL;Nimustine USP/EP/BP;pimustine hydrochloride;1,2-DibroMo-3-chloropropane Standard
CBNumber: CB4231103
Molecular Formula: C9H13ClN6O2
Formula Weight: 272.69
MOL File: 42471-28-3.mol

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Nimustine Property

Melting point:: 125°C (rough estimate)
Boiling point:: 98°C (rough estimate)
Density: 1.9048 (rough estimate)
refractive index: 1.5790 (estimate)
pka: 9.58±0.46(Predicted)
form: solid
CAS DataBase Reference: 42471-28-3(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: YR8450000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0003580
Product name: NIMUSTINE
Purity: 95.00%
Packaging: 100MG
Price: $402.7
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003580
Product name: NIMUSTINE
Purity: 95.00%
Packaging: 1G
Price: $427.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003580
Product name: NIMUSTINE
Purity: 95.00%
Packaging: 5G
Price: $537.5
Updated: 2021/12/16

AHH

Product number: API-1243
Product name: Nimustine
Purity: 98%
Packaging: 10g
Price: $320
Updated: 2021/12/16

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Nimustine Chemical Properties,Usage,Production

Originator

Nidran,Sankyo,Japan,1979

Definition

ChEBI: An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-amino-2-methylpyrimidin-5-ylmethyl] group. An anti eoplastic agent especially effective against malignant brain tumors.

Manufacturing Process

0.4 g of sodium nitrite was added with stirring, at 0°C to 5°C, to a solution of 450 mg of 1-(2-chloroethyl)-3-[(2-methyl-4-aminopyridin-5-yl)methyl]urea in 8 ml of 5% hydrochloric acid, and the reaction mixture was then stirred at 0°C to 10°C for an additional 1.5 hours.
After completion of the reaction, the reaction mixture was made alkaline by the addition of sodium carbonate, whereupon crystals separated out in situ. The crystals were recovered by filtration, washed with water and then recrystallized from 6 ml of ethanol, to give 0.1 g of the pale yellow pure desired product having a decomposition point of 125°C.

Therapeutic Function

Antitumor, Antileukemic

Nimustine Preparation Products And Raw materials

Raw materials

Preparation Products

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Nimustine Suppliers

China 54 Europe 2 Germany 2 India 1 Switzerland 1 Ukraine 1 United Kingdom 6 United States 19 Global 86

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View Lastest Price from Nimustine manufacturers

Dideu Industries Group Limited

Product: Nimustine 42471-28-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-05

Career Henan Chemical Co

Product: Nimustine 42471-28-3
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-01-08

42471-28-3, NimustineRelated Search:

Ethylurea Bendamustine Semicarbazide Kresoxim-methyl Methyl acrylate Thiophanate-methyl METSULFURON METHYL Bensulfuron methyl Bendamustine hydrochloride Methylparaben Methyl acetate Methyl Methyl bromide NIMUSTINE HYDROCHLORIDE,NIMUSTINE HCL Parathion-methyl 1-Methyl-1-nitrosourea N-NITROSO-N-ETHYLUREA Chlorine

1-(4-AMINO-2-METHYL-5-PYRIMIDINYL)-METHYL-3-(2-CHLOROETHYL)-3-NITROSOUREA HYDROCHLORIDE

1-((4-amino-2-methylpyrimidin-5-yl)methyl)-3-(2-chloroethyl)-3-nitrosourea

NIMUSTINE

NIMUSTINE HCL

N'-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-N-(2-CHLORETHYL)-N-NITROSOUREA

ACNU

3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride

3-(4-amino-2-methyl-5-pyrimidinyl)methyl-1-(2-chloroethyl)-1-nitrosourea

n’-((4-amino-2-methyl-5-pyrimidinyl)methyl)-n-(2-chloroethyl)-n-nitroso-ure

Nimustin

1-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea

3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea

1,2-DibroMo-3-chloropropane Standard

NITROSOUREA

NIFUMICACID

Urea, N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-

Nimustine USP/EP/BP

ACNU 50

pimustine hydrochloride

NimustineNIMUSTIN</NOBR><br>CAS:42471-28-3<BR>CAND-1042

42471-28-3

1996-12-8

42471-28-6

C9H13ClN6O2

DNA Intercalators and Crosslinkers

DNA metabolism

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BioChemical

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