L-Aspartic acid 4-benzyl ester

Product Name: L-Aspartic acid 4-benzyl ester
CAS No.: 2177-63-1
Chemical Name: L-Aspartic acid 4-benzyl ester
Synonyms: H-ASP(OBZL)-OH;L-Aspartic acid β-benzyl ester;Asp(OBz)-OH;H-Asp(OBn)-OH;H-L-Asp(Bzl)-OH;H-L-ASP(OBZL)-OH;H-ASP(OBZL)-OH 98%;B-BENZYL L-ASPARTATE;4-BENZYL L-ASPARTATE;á-benzyl l-aspartate
CBNumber: CB4232504
Molecular Formula: C11H13NO4
Formula Weight: 223.23
MOL File: 2177-63-1.mol

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L-Aspartic acid 4-benzyl ester Property

Melting point:: ~225 °C (dec.)
Boiling point:: 413.1±45.0 °C(Predicted)
Density: 1.283±0.06 g/cm3(Predicted)
refractive index: 27 ° (C=1, 1mol/L HCl)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 2.16±0.23(Predicted)
form: Powder
color: White
Water Solubility: Insoluble in water.
BRN: 1983183
CAS DataBase Reference: 2177-63-1(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B2129
Product name: L-Aspartic acid β-benzyl ester
Packaging: 25g
Price: $368
Updated: 2025/07/31

TCI Chemical

Product number: B3209
Product name: 4-Benzyl L-Aspartate
Purity: >98.0%(T)
Packaging: 5g
Price: $57
Updated: 2025/07/31

TCI Chemical

Product number: B3209
Product name: 4-Benzyl L-Aspartate
Purity: >98.0%(T)
Packaging: 25g
Price: $192
Updated: 2025/07/31

TRC

Product number: A788668
Product name: H-Asp(OBzl)-OH
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA47538
Product name: L-Aspartic acid b-benzyl ester
Packaging: 50g
Price: $60
Updated: 2021/12/16

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L-Aspartic acid 4-benzyl ester Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Aspartic acid β-benzyl ester is used in the synthesis of peptides with a 1,4-diazepine-2,5-dione ring structure and in development of block copolymers.

Definition

ChEBI: L-aspartic acid beta-benzyl ester is an aspartic acid derivative.

Synthesis

56-84-8

100-51-6

2177-63-1

100 mL of anhydrous ether was added to a 500 mL beaker and 20 mL of concentrated sulfuric acid was added slowly and dropwise while stirring and cooling to room temperature. Subsequently, 150 mL of benzyl alcohol was added and the ether was removed by stirring well. Under reduced pressure, 26 g of L-aspartic acid was added to the reaction flask in 5 batches. The reaction was stirred for 24 h at room temperature, after which 300 mL of 95% ethanol was added, and 80 mL of pyridine was slowly added dropwise through a dropping funnel with vigorous stirring while dropping. The reaction mixture was placed in a refrigerator overnight and the solid was collected by filtration. The solid was dissolved with 80% ethanol with stirring, heated and filtered. The filtrate was frozen for 8 hours, filtered again and finally lyophilized to obtain pure β-aspartic acid benzyl ester in 90% yield.

References

[1] Journal of Natural Products, 2017, vol. 80, # 7, p. 2136 - 2140
[2] Patent: CN107129501, 2017, A. Location in patent: Paragraph 0009; 0010; 0011
[3] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2011, vol. 41, # 5, p. 459 - 464
[4] Patent: US2004/133033, 2004, A1. Location in patent: Page 4-5
[5] Chemistry - A European Journal, 2018, vol. 24, # 54, p. 14373 - 14377

L-Aspartic acid 4-benzyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Aspartic acid 4-benzyl ester Suppliers

Americas 1 China 230 Europe 3 France 2 Germany 7 India 12 Japan 5 South Korea 1 Switzerland 6 United Kingdom 13 United States 51 Global 331

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View Lastest Price from L-Aspartic acid 4-benzyl ester manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: H-Asp(OBzl)-OH 2177-63-1
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-26

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-Asp(OBzl)-OH 2177-63-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-12

Henan Aochuang Chemical Co.,Ltd.

Product: L-Aspartic acid 4-benzyl ester 2177-63-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-13

2177-63-1, L-Aspartic acid 4-benzyl esterRelated Search:

L-Aspartic acid dibenzyl ester 4-toluenesulfonate L-ASPARTIC ACID Methyl acrylate Benzyl benzoate Benzyl bromide Tris(trimethylsilyl)phosphate Benzyl alcohol Poly-L-aspartic acid L-Aspartic acid Sodium L-aspartate H-Asp(OAll)-OH.HCl H-ASP(OBZL)-OBZL HCL H-ASP(OBZL)-NH2 HCL N-Cbz-L-Aspartic acid 4-benzyl ester BOC-ASP(OBZL)-OSU FMOC-ASP(O-2-PHIPR)-OH Fmoc-L-Aspartic acid-1-benzyl ester Boc-L-aspartic acid 4-benzyl ester

H-ASP(OBZL)-OH

H-L-ASP(OBZL)-OH

L-ASPARTIC ACID 4-BENZYL ESTER

L-ASPARTIC ACID BETA-BENZYL ESTER

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BETA-BENZYL L-ASPARTATE

benzyl hydrogen beta-L-aspartate

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B-BENZYL L-ASPARTATE

ALPHA-BENZYL-L-ASPARTATE

cis-3,4-DMETHYL-2-HEXENE

á-benzyl l-aspartate

(2S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid

(2S)-2-amino-4-oxo-4-phenylmethoxybutanoic acid

(S)-2-Amino-4-(benzyloxy)-4-oxobutanoicacid

Aspartic acid, 4-benzyl ester

H-L-Asp(Bzl)-OH

L-ASPARTIC ACID-B-BENZYLESTER

H-Asp(OBn)-OH

Aspartic acid, 4-(phenylmethyl) ester

β-Benzyl L-aspartate, L-Aspartic acid 4-benzyl ester

(2S)-2-Amino-4-oxo-4-(benzyloxy)butyric acid

3-(Benzyloxycarbonyl)-L-alanine

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H-Asp(OBzl)-OH ] L-Aspartic acid β-benzyl ester

L-Aspartic acid β-benzyl ester, >=98%

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4-BenzylL-Aspartate&gt

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(2S)-2-amino-4-oxo-4-phenylmethoxybutanoicaci

L-Aspartic acid 4-benzyl ester USP/EP/BP

4-(Phenylmethyl) hydrogen L-aspartate

<sc>L</sc>-Aspartic acid β-benzyl ester

H-ASP(OBZL)-OH 98%

4-(Benzyl) hydrogen L-aspartate

2177-63-1

21777-63-1

C6H5CH2OCOCH2CHNH2COOH

Amino Acids Derivatives

Aspartic acid [Asp, D]

Amino Acids and Derivatives

Amino Acids

alpha-Amino Acids

Amino Acid Benzyl Esters

Amino Acids (C-Protected)

Biochemistry

AMINOACIDS DERIVATIVES