Fmoc-L-Aspartic acid-1-benzyl ester

Product Name: Fmoc-L-Aspartic acid-1-benzyl ester
CAS No.: 86060-83-5
Chemical Name: Fmoc-L-Aspartic acid-1-benzyl ester
Synonyms: FMOC-ASP-OBZL;FMOC-L-ASP-OBZL;Fmoc-Asp-OBzl, 98.5%;FMOC-ASPARTIC ACID-OBZL;N-9-FLUORENYLMETHYLOXYCAR;FmocAsparticα-benzylester;Fmoc-Asp-OBzlFmoc-Asp-OBzl;Fmoc-Asp-OBzl Novabiochem;Fmoc Aspartic α-benzyl ester;Fmoc-L-aspartic acid α-benzyl ester
CBNumber: CB7291177
Molecular Formula: C26H23NO6
Formula Weight: 445.46
MOL File: 86060-83-5.mol

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Fmoc-L-Aspartic acid-1-benzyl ester Property

Boiling point:: 683.7±55.0 °C(Predicted)
Density: 1.310±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in water or 1% acetic acid
pka: 4.05±0.19(Predicted)
form: Powder
color: White
optical activity: -13.9393°(C=0.9032g/100ml MEOH)
InChIKey: CBZSVHFNEMONDZ-QHCPKHFHSA-N
SMILES: C(OCC1=CC=CC=C1)(=O)[C@H](CC(O)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference: 86060-83-5(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52220
Product name: Fmoc-Asp-OBzl
Purity: Novabiochem?
Packaging: 5G
Price: $67.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52220
Product name: Fmoc-Asp-OBzl
Purity: Novabiochem?
Packaging: 1G
Price: $25.3
Updated: 2023/06/20

TRC

Product number: F604180
Product name: Fmoc-asp-obzl
Packaging: 250mg
Price: $85
Updated: 2021/12/16

Usbiological

Product number: 277214
Product name: Fmoc-L-aspartic acid alpha-benzyl ester
Packaging: 1g
Price: $369
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002562
Product name: FMOC-L-ASPARTIC ACID-1-BENZYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $498.63
Updated: 2021/12/16

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Fmoc-L-Aspartic acid-1-benzyl ester Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

117854-05-4

86060-83-5

Fmoc-Asp(OtBu)-OBn (1.604 g, 3.197 mmol) was used as a raw material and dissolved in 15 mL of freshly distilled dichloromethane (CH2Cl2). To this solution 15 mL of formic acid (HCOOH) was added and the reaction mixture was stirred at room temperature overnight. The reaction progress was monitored by thin layer chromatography (TLC) and after confirming the complete conversion of the feedstock, the volatiles were removed by distillation under reduced pressure. Subsequently, residual formic acid was removed by co-evaporation with dichloromethane to afford the white solid product Fmoc-Asp(OH)-OBn (1.310 g, 2.94 mmol, 92% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and 13C NMR (101 MHz, CDCl3).1H NMR data were as follows: δ 11.15 (s, 1H), 7.80 (d, J=7.5 Hz, 2H), 7.66 (d, J=7.4 Hz, 2H), 7.44 (t, J=7.4 Hz, 2H ), 7.36 (m, 7H), 6.16 (d, J=8.5Hz, 1H), 5.26 (s, 2H), 4.83 (dt, J=8.6,4.4Hz, 1H), 4.50 (dd, J=10.4,7.4Hz, 1H), 4.46-4.38 (m, 1H), 4.26 (t, J=7.1Hz, 1H), 4.26 (t, J=7.1Hz, 1H), and 3.18 (dd, J=17.4,4.6 Hz, 1H), 3.01 (dd, J=17.4,4.2 Hz, 1H).13C NMR data were as follows: δ 175.36, 170.34, 156.04, 143.53, 143.39, 141.02, 134.84, 128.34, 128.20, 127.94, 127.51, 126.87, 124.90, 119.76, 67.44, 67.21, 50.18, 46.79, 36.12.

References

[1] Journal of the American Chemical Society, 2003, vol. 125, # 40, p. 12100 - 12101
[2] Patent: WO2018/106112, 2018, A1. Location in patent: Page/Page column 50; 51
[3] Carbohydrate Research, 1988, vol. 174, p. 279 - 290
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 24, p. 7306 - 7308
[5] European Journal of Medicinal Chemistry, 2014, vol. 73, p. 225 - 232

Fmoc-L-Aspartic acid-1-benzyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-L-Aspartic acid-1-benzyl ester Suppliers

China 130 Europe 2 Germany 4 India 2 Japan 2 United Kingdom 5 United States 27 Global 172

Nextpeptide Inc

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Capot Chemical Co., Ltd

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Pure Chemistry Scientific Inc.

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Accela ChemBio Co.,Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
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View Lastest Price from Fmoc-L-Aspartic acid-1-benzyl ester manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-Asp-Obzl 86060-83-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-21

Shaanxi Dideu Medichem Co. Ltd

Product: Fmoc-L-Aspartic acid-1-benzyl ester 86060-83-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Career Henan Chemical Co

Product: Fmoc-L-Aspartic acid-1-benzyl ester 86060-83-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-22

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86060-83-5

C26H23NO6

Aspartic acid [Asp, D]

Fmoc-Amino Acids and Derivatives

Fmoc-Amino acid series