2-Bromo-6-chlorobenzoic acid
- Product Name
- 2-Bromo-6-chlorobenzoic acid
- CAS No.
- 93224-85-2
- Chemical Name
- 2-Bromo-6-chlorobenzoic acid
- Synonyms
- AKOS MSC-0781;BUTTPARK 51\01-28;2-Bromo-6-chlorobenzoicaci;6-bromo-2-chloroBenzoic acid;2-BROMO-6-CHLOROBENZOIC ACID;3-bromo-2-chloro-benzoic acid;Benzoic acid, 2-broMo-6-chloro-;2-Bromo-6-chlorobenzoic acid, CAS 93224-85-2;2-Bromo-6-chlorobenzoic acid ISO 9001：2015 REACH
- CBNumber
- CB4236698
- Molecular Formula
- C7H4BrClO2
- Formula Weight
- 235.46
- MOL File
- 93224-85-2.mol
2-Bromo-6-chlorobenzoic acid Property
- Melting point:
- 148-152 °C
- Boiling point:
- 315.9±27.0 °C(Predicted)
- Density
- 1.809±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- powder to crystal
- pka
- 1.62±0.10(Predicted)
- color
- White to Orange to Green
- InChIKey
- URGXUQODOUMRFP-UHFFFAOYSA-N
- CAS DataBase Reference
- 93224-85-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-45
- RIDADR
- 2811
- WGK Germany
- 2
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B4820
- Product name
- 2-Bromo-6-chlorobenzoic Acid
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $30
- Updated
- 2025/07/31
- Product number
- B4820
- Product name
- 2-Bromo-6-chlorobenzoic Acid
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $88
- Updated
- 2025/07/31
- Product number
- B682535
- Product name
- 2-Bromo-6-chlorobenzoic acid
- Packaging
- 25g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 2621-D-02
- Product name
- 2-Bromo-6-chlorobenzoic acid
- Packaging
- 100g
- Price
- $504
- Updated
- 2021/12/16
- Product number
- FB139787
- Product name
- 2-Bromo-6-chlorobenzoic acid
- Packaging
- 250g
- Price
- $577.5
- Updated
- 2021/12/16
2-Bromo-6-chlorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
off-white powder
Uses
2-Bromo-6-chlorobenzoic acid is used in the syntheis of Diclofenac Monobromo Sodium Salt Impurity (D436490).
Synthesis
108-37-2
124-38-9
93224-85-2
Step 1. Synthesis of 2-bromo-6-chlorobenzoic acid: Diisopropylamine (3.5 mL, 25 mmol) was slowly added to a tetrahydrofuran (THF, 70 mL) solution of n-butyllithium (n-BuLi, 10 mL, 25 mmol, 2.5 M hexane solution) cooled at -78 °C under anhydrous conditions. After stirring the reaction mixture for 15 minutes, 1-chloro-3-bromobenzene (4.32 g, 25 mmol) was added dropwise and stirring was continued at -78 °C for 2 hours. Subsequently, dry ice (solid CO2) was added to the reaction system and after 15 min of reaction, aqueous 2N hydrochloric acid (100 mL) was slowly added to quench the reaction. The reaction mixture was extracted with ethyl acetate (EtOAc) and the organic phases were combined. The product was purified by recrystallization from hexane and finally isolated to give 5 g of 2-bromo-6-chlorobenzoic acid in 85% yield.
References
[1] Organic Letters, 2009, vol. 11, # 5, p. 1051 - 1054
[2] Tetrahedron Letters, 1997, vol. 38, # 9, p. 1559 - 1562
[3] Patent: WO2008/124582, 2008, A1. Location in patent: Page/Page column 117
[4] Patent: WO2008/124575, 2008, A1. Location in patent: Page/Page column 108
[5] Organic Process Research and Development, 2005, vol. 9, # 6, p. 764 - 767
2-Bromo-6-chlorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-6-chlorobenzoic acid manufacturers
- Product
- 2-Bromo-6-chlorobenzoic acid 93224-85-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24