ChemicalBook > CAS DataBase List > DIACYLGLYCEROL KINASE INHIBITOR II

DIACYLGLYCEROL KINASE INHIBITOR II

Product Name
DIACYLGLYCEROL KINASE INHIBITOR II
CAS No.
120166-69-0
Chemical Name
DIACYLGLYCEROL KINASE INHIBITOR II
Synonyms
R59949;R-59949(R-59-949);DAG Kinase Inhibitor;DAG Kinase Inhibitor II;DIACYLGLYCEROL KINASE INHIBITOR II;Diacylglycerol Kinase Inhibitor II solid;DIACYLGLYCEROL KINASE INHIBITOR I (R59 949);DIACYLGLYCEROL KINASE INHIBITOR II (R 59 949);Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem;3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
CBNumber
CB4239260
Molecular Formula
C28H25F2N3OS
Formula Weight
489.58
MOL File
120166-69-0.mol
More
Less

DIACYLGLYCEROL KINASE INHIBITOR II Property

Melting point:
228-230 °C
Boiling point:
637.1±65.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
0.1 M HCl: slightly soluble
form 
solid
pka
11.24±0.20(Predicted)
color 
pale yellow
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D5794
Product name
Diacylglycerol Kinase Inhibitor II
Purity
solid
Packaging
1mg
Price
$36.18
Updated
2024/03/01
Sigma-Aldrich
Product number
266788
Product name
Diacylglycerol Kinase Inhibitor II
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
21221
Product name
R-59-949
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21221
Product name
R-59-949
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
D5794
Product name
Diacylglycerol Kinase Inhibitor II
Purity
solid
Packaging
5mg
Price
$173
Updated
2024/03/01
More
Less

DIACYLGLYCEROL KINASE INHIBITOR II Chemical Properties,Usage,Production

Description

R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. DGK-α inhibition with R-59-949 increases diacylglycerol-dependent PKC activity, serotonin secretion, and aggregation of thrombin-stimulated platelets. R-59-949 inhibits DGK-α activity induced by platelet-derived growth factor (PDGF) in intact vascular smooth muscle cells (VSMCs). It inhibits high K+- and glucose-induced insulin secretion in MIN6 pancreatic β-cells in a dose-dependent manner. In vivo, administration of R-59-949 prevents retinal neovascularization in a mouse model of oxygen-induced retinopathy.

Uses

Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.

Definition

ChEBI: 3-[2-[4-[bis(4-fluorophenyl)methylidene]-1-piperidinyl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one is a diarylmethane.

Biochem/physiol Actions

Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.

DIACYLGLYCEROL KINASE INHIBITOR II Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

DIACYLGLYCEROL KINASE INHIBITOR II Suppliers

Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82

120166-69-0, DIACYLGLYCEROL KINASE INHIBITOR IIRelated Search:


  • DIACYLGLYCEROL KINASE INHIBITOR I (R59 949)
  • DIACYLGLYCEROL KINASE INHIBITOR II
  • R59949, 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
  • 3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
  • 3-[2-[4-(bis(4-Fluorophenyl)Methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, R59949
  • DAG Kinase Inhibitor II
  • DAG Kinase Inhibitor
  • 3-[2-(4-[BIS(4-FLUOROPHENYL)-METHYLENE)-1-PIPERIDINYL)ETHYL]-2,3-DIHYDRO-2-THIOXO-4[1H]-QUINAZOLINONE
  • R59949
  • DIACYLGLYCEROL KINASE INHIBITOR II (R 59 949)
  • 3-[2-[4-(bis(4-fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1h)-quinazolinone
  • Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem
  • 4(1H)-Quinazolinone, 3-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-
  • Diacylglycerol Kinase Inhibitor II solid
  • R-59949(R-59-949)
  • 3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one
  • kinase,endogenous,PKC,plasma,platelet,diacylglycerol,Protein kinase C,Inhibitor,R59949,inhibit,ligand,membranes
  • 3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
  • 120166-69-0
  • C28H25F2N3OS
  • Serine/Threonine Kinase Inhibitors
  • Kinase/Phosphatase Biology
  • Diacylglycerol kinase (DAGK)
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • quinazolinone