Alisol C 23-acetate
- Product Name
- Alisol C 23-acetate
- CAS No.
- 26575-93-9
- Chemical Name
- Alisol C 23-acetate
- Synonyms
- 23-Acetyl alisol C;Alisol C 23-acetate;Alisol C-monoacetat;23-O-Acetylalisol C;Alisol C monoacetate;Alisol C 23-monoacetate;Alisol C 23-acetate, 10 mM in DMSO;Alisol C (23-acetate) (23-O-Acetylalisol C;(8α,9β,14β,23S,24R)-23-Acetoxy-24,25-epoxy-11β-hydroxydammar-13(17)-ene-3,16-dione;(8α,9β,14β,23S,24R)-23-Acetoxy-11β-hydroxy-24,25-epoxydammar-13(17)-ene-3,16-dione
- CBNumber
- CB42400392
- Molecular Formula
- C32H48O6
- Formula Weight
- 528.72
- MOL File
- 26575-93-9.mol
Alisol C 23-acetate Property
- Boiling point:
- 624.9±55.0 °C(Predicted)
- Density
- 1.15
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- powder
- pka
- 14.36±0.70(Predicted)
- color
- White
- InChIKey
- KOOCQNIPRJEMDH-QSKXMHMESA-N
N-Bromosuccinimide Price
- Product number
- 299895
- Product name
- Alisol C Monoacetate
- Packaging
- 10mg
- Price
- $581
- Updated
- 2021/12/16
- Product number
- FA73941
- Product name
- Alisol C monoacetate
- Packaging
- 2mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- Y0025
- Product name
- AlisolCmonoacetate
- Packaging
- 2mg
- Price
- $167
- Updated
- 2021/12/16
- Product number
- FA73941
- Product name
- Alisol C monoacetate
- Packaging
- 5mg
- Price
- $173
- Updated
- 2021/12/16
- Product number
- FA73941
- Product name
- Alisol C monoacetate
- Packaging
- 10mg
- Price
- $300
- Updated
- 2021/12/16
Alisol C 23-acetate Chemical Properties,Usage,Production
Description
Alisol C 23-acetate, a natural product extracted from Alisma orientale, can significantly and strongly inhibit DTH response after oral administration.
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Alisma orientalis.
Uses
Alisol C 23-acetate, a natural product extracted from Alisma orinentale, can significantly and strongly inhibit DTH response after oral administration.
Biological Activity
Alisol B 23-acetate produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes.
Synthesis
100kg of raw materials crushed to 40 mesh, with 200kg concentration of 0.1% potassium hydroxide solution wetting for 4h, using a concentration of 80% ethanol extraction 3 times, each time the extraction of 2h, the extract is concentrated and ready for use.
The extraction and concentration using the material of PVC tubular membrane for liquid clarification, the molecular weight cut-off for 2000-5000dalton, collect the clear liquid and concentrated liquid, the clear liquid continues to be separated by nanofiltration membrane, the material used is PVDF hollow fiber membrane, the molecular weight cut-off for 150-450dalton, collect the concentrated liquid, concentrate and then dry;
The dried powder, at 40 , using 2 times the mass of dried powder dichloromethane and acetone mixed solvent dissolved for 1h, the mass ratio of 1:1, filtration, concentrated to 1 times the mass of dried powder, placed on standby;
To 40 concentrate first add 1% of the mass of concentrate of the ZTCIA + B-type clarifying agent, which the concentration of A, B, are 2%, stirring to add the first B, to be After stirring for 10 minutes, add A, the mass ratio of B and A is 2:1, 40 heat preservation for 20 minutes; then add 1% of the mass of the concentrate concentration of 2.0% of the nonionic flocculant, 40 under the condition of heat preservation for 1h, filtration, the filtrate is concentrated to the original volume of 0.1 times the volume of the concentration of 98% ethanol to the concentrate to add 0.1 times the mass of the concentrate, placed on the crystallization, centrifugal drying, to obtain 180g, the content of 98.0%, the concentration of 98% ethanol, the concentration of 98%, the concentration of 98%, the concentration of 98%. Get 180g, the content of 98.2% of the product.
References
[1] Lee JH, et al. The rhizomes of Alisma orientale and alisol derivatives inhibit allergic response and experimental atopic dermatitis. Biol Pharm Bull. 2012;35(9):1581-7. DOI:10.1248/bpb.b110689
Alisol C 23-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Alisol C 23-acetate manufacturers
- Product
- Alisol C monoacetate 26575-93-9
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-05