Madecassoside

Product Name: Madecassoside
CAS No.: 34540-22-2
Chemical Name: Madecassoside
Synonyms: RederMic;MADECASSOIDE;MADECASSOSIDE;Asiaticoside A;MADECASSOSIDE(P);Madecassoside-RM;MADECASSOSIDE hplc;Madecassoside (8CI);MADECASSOSIDE WITH HPLC;Madecassoside (Asiaticoside A)
CBNumber: CB6210654
Molecular Formula: C48H78O20
Formula Weight: 975.12
MOL File: 34540-22-2.mol

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Madecassoside Property

Melting point:: 220-223 °C
Boiling point:: 1043.6±65.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H2O: soluble1mg/mL, clear, colorless
pka: 12.50±0.70(Predicted)
form: powder
color: white to off-white
Stability:: Hygroscopic
InChIKey: BNMGUJRJUUDLHW-CIZDPPTDSA-N
LogP: -1.338 (est)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: YU9555000
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M6949
Product name: Madecassoside from Centella asiatica
Purity: ≥95% % (HPLC)
Packaging: 10mg
Price: $185
Updated: 2024/03/01

Sigma-Aldrich

Product number: M6949
Product name: Madecassoside from Centella asiatica
Purity: ≥95% % (HPLC)
Packaging: 50mg
Price: $225.6
Updated: 2024/03/01

Cayman Chemical

Product number: 11855
Product name: Madecassoside
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 11855
Product name: Madecassoside
Purity: ≥98%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 11855
Product name: Madecassoside
Purity: ≥98%
Packaging: 25mg
Price: $249
Updated: 2024/03/01

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Madecassoside Chemical Properties,Usage,Production

Description

Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica. It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.

Chemical Properties

Madecassoside is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of madecassoside in these solvents is approximately 5, 10, and 25 mg/ml, respectively.H2O : 33.33 mg/mL (34.18 mM)

Uses

Madecassoside is an antioxidant and anti-inflammatory agent. Used as a protective agent against cognitive impairment.

Definition

ChEBI: A triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities.

Mechanism of action

Madecassoside can directly reduce the cytoskeletal protein actin expression of KFs and its mechanism of action is by inhibiting the activity of some (not all) of the several intracellular molecules that are responsible for abnormal keloid migration, including the significant, concentration‐dependent reduction of phosphorylated Akt, PI3K and p38 of KFs and the repression of actin‐depolymerization‐associated p‐cofilin/cofilin[1].

References

[1] Bandopadhyay s, et al. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review. J. Cell. Mol. Med, 2023; 27: 593–608.

Madecassoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Madecassoside Suppliers

China 256 France 1 Germany 3 India 3 Japan 1 South Korea 1 United Kingdom 7 United States 31 USA 1 Global 304

Guilin Benefittw Biotechnology Co.,LTD.

Tel: 0773-0773-8280552 18978691595
Fax: 0773-8280552
Email: 935960@qq.com
Country: China
ProdList: 40
Advantage: 58

Shaanxi Pioneer Biotech Co., Ltd.

Tel: 029-029-86629612 18202932191
Email: sales3@pioneerbiotech.com
Country: China
ProdList: 270
Advantage: 55

Xi'an Jianglin Biotechnology Co., Ltd

Tel: 18292036798; 18292036798
Email: JLSW00@163.com
Country: China
ProdList: 32
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8836
Advantage: 52

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

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View Lastest Price from Madecassoside manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Madecassoside 34540-22-2
Price: US $48.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-14

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Madecassoside 34540-22-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg/month
Release date: 2021-07-20

BINBO BIOLOGICAL CO.,LTD

Product: Madecassoside 34540-22-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-09

34540-22-2, MadecassosideRelated Search:

Asiaticoside Centella asiatica extract Total Of Triterpenes PROPYLENE GLYCOL BUTYL ETHER METHYL 13-METHYLTETRADECANOATE 1,12-OCTADECANEDIOL isobutoxypropanol 6-O-BETA-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE isohexadecanoic acid 2-Ethyl-1,3-hexanediol MONOLAURIN MONOCAPRYLIN Isopropyl-cyclohexanecarboxylic acid METHYL 15-HYDROXYPENTADECANOATE 15-HYDROXYPENTADECANOIC ACID N-PENTADECANOIC ACID ETHYL ESTER ETHYL 2,2-DIETHYLBUTYRATE 1,3-DIISOPROPYLCYCLOHEXANE

Madecassoside, 98%, from Centella asiatica

MADECASSOIDE

MADECASSOSIDE

O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate

O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate

MADECASSOSIDE(P)

MADECASSOSIDE hplc

Asiaticoside A

glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)-

Urs-12-en-28-oicacid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-

2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid 6-O-[4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl ester

RederMic

MADECASSOSIDE WITH HPLC

Madecassoside, froM Centella asiatica

Madecassoside, 98%, from Centella asiatica (L.) Urb.

Madecassoside (Asiaticoside A)

Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)-

Madecassoside (8CI)

(1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate

Centella Asiatica Extract Madecassoside

Madecassoside-RM

34540-22-2

C48H78O20

Inhibitors

The group of Asiaticoside

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Saponins