Madecassoside
- Product Name
- Madecassoside
- CAS No.
- 34540-22-2
- Chemical Name
- Madecassoside
- Synonyms
- RederMic;MADECASSOIDE;MADECASSOSIDE;Asiaticoside A;MADECASSOSIDE(P);MADECASSOSIDE hplc;Madecassoside (8CI);MADECASSOSIDE WITH HPLC;Madecassoside (Asiaticoside A);Madecassoside, froM Centella asiatica
- CBNumber
- CB6210654
- Molecular Formula
- C48H78O20
- Formula Weight
- 975.12
- MOL File
- 34540-22-2.mol
Madecassoside Property
- Melting point:
- 220-223 °C
- Boiling point:
- 1043.6±65.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble1mg/mL, clear, colorless
- pka
- 12.50±0.70(Predicted)
- form
- powder
- color
- white to off-white
- Stability:
- Hygroscopic
- InChIKey
- BNMGUJRJUUDLHW-CIZDPPTDSA-N
- LogP
- -1.338 (est)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- YU9555000
- HS Code
- 29389090
N-Bromosuccinimide Price
- Product number
- M6949
- Product name
- Madecassoside from Centella asiatica
- Purity
- ≥95% % (HPLC)
- Packaging
- 10mg
- Price
- $185
- Updated
- 2024/03/01
- Product number
- M6949
- Product name
- Madecassoside from Centella asiatica
- Purity
- ≥95% % (HPLC)
- Packaging
- 50mg
- Price
- $225.6
- Updated
- 2024/03/01
- Product number
- 11855
- Product name
- Madecassoside
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 11855
- Product name
- Madecassoside
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 11855
- Product name
- Madecassoside
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $249
- Updated
- 2024/03/01
Madecassoside Chemical Properties,Usage,Production
Description
Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica. It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.
Chemical Properties
Madecassoside is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of madecassoside in these solvents is approximately 5, 10, and 25 mg/ml, respectively.H2O : 33.33 mg/mL (34.18 mM)
Uses
Madecassoside is an antioxidant and anti-inflammatory agent. Used as a protective agent against cognitive impairment.
Definition
ChEBI: A triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities.
Mechanism of action
Madecassoside can directly reduce the cytoskeletal protein actin expression of KFs and its mechanism of action is by inhibiting the activity of some (not all) of the several intracellular molecules that are responsible for abnormal keloid migration, including the significant, concentration‐dependent reduction of phosphorylated Akt, PI3K and p38 of KFs and the repression of actin‐depolymerization‐associated p‐cofilin/cofilin[1].
References
[1] Bandopadhyay s, et al. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review. J. Cell. Mol. Med, 2023; 27: 593–608.
Madecassoside Preparation Products And Raw materials
Raw materials
Preparation Products
Madecassoside Suppliers
View Lastest Price from Madecassoside manufacturers
- Product
- Madecassoside 34540-22-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- ≥98%
- Supply Ability
- 20tons
- Release date
- 2024-01-05
- Product
- Madecassoside 34540-22-2
- Price
- US $8.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-23
- Product
- Madecassoside 34540-22-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-09