Madecassoside

ChemicalBook > CAS DataBase List > Madecassoside

Product Name: Madecassoside
CAS No.: 34540-22-2
Chemical Name: Madecassoside
Synonyms: RederMic;MADECASSOIDE;MADECASSOSIDE;Asiaticoside A;MADECASSOSIDE(P);MADECASSOSIDE hplc;Madecassoside (8CI);MADECASSOSIDE WITH HPLC;Madecassoside (Asiaticoside A);Madecassoside, froM Centella asiatica
CBNumber: CB6210654
Molecular Formula: C48H78O20
Formula Weight: 975.12
MOL File: 34540-22-2.mol

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Madecassoside Property

Melting point:: 220-223 °C
Boiling point:: 1043.6±65.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H2O: soluble1mg/mL, clear, colorless
pka: 12.50±0.70(Predicted)
form: powder
color: white to off-white
Stability:: Hygroscopic
InChIKey: BNMGUJRJUUDLHW-CIZDPPTDSA-N
LogP: -1.338 (est)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: YU9555000
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M6949
Product name: Madecassoside from Centella asiatica
Purity: ≥95% % (HPLC)
Packaging: 10mg
Price: $185
Updated: 2024/03/01

Sigma-Aldrich

Product number: M6949
Product name: Madecassoside from Centella asiatica
Purity: ≥95% % (HPLC)
Packaging: 50mg
Price: $225.6
Updated: 2024/03/01

Cayman Chemical

Product number: 11855
Product name: Madecassoside
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 11855
Product name: Madecassoside
Purity: ≥98%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 11855
Product name: Madecassoside
Purity: ≥98%
Packaging: 25mg
Price: $249
Updated: 2024/03/01

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Madecassoside Chemical Properties,Usage,Production

Description

Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica. It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.

Chemical Properties

Madecassoside is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of madecassoside in these solvents is approximately 5, 10, and 25 mg/ml, respectively.H2O : 33.33 mg/mL (34.18 mM)

Uses

Madecassoside is an antioxidant and anti-inflammatory agent. Used as a protective agent against cognitive impairment.

Definition

ChEBI: A triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities.

Mechanism of action

Madecassoside can directly reduce the cytoskeletal protein actin expression of KFs and its mechanism of action is by inhibiting the activity of some (not all) of the several intracellular molecules that are responsible for abnormal keloid migration, including the significant, concentration‐dependent reduction of phosphorylated Akt, PI3K and p38 of KFs and the repression of actin‐depolymerization‐associated p‐cofilin/cofilin[1].

References

[1] Bandopadhyay s, et al. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review. J. Cell. Mol. Med, 2023; 27: 593–608.

Madecassoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Madecassoside Suppliers

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View Lastest Price from Madecassoside manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Madecassoside 34540-22-2
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2024-01-05

Henan Fengda Chemical Co., Ltd

Product: Madecassoside 34540-22-2
Price: US $8.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-23

BINBO BIOLOGICAL CO.,LTD

Product: Madecassoside 34540-22-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-09

34540-22-2, MadecassosideRelated Search:

Asiaticoside Centella asiatica extract Total Of Triterpenes PROPYLENE GLYCOL BUTYL ETHER METHYL 13-METHYLTETRADECANOATE 1,12-OCTADECANEDIOL isobutoxypropanol 6-O-BETA-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE isohexadecanoic acid 2-Ethyl-1,3-hexanediol MONOLAURIN MONOCAPRYLIN Isopropyl-cyclohexanecarboxylic acid METHYL 15-HYDROXYPENTADECANOATE 15-HYDROXYPENTADECANOIC ACID N-PENTADECANOIC ACID ETHYL ESTER ETHYL 2,2-DIETHYLBUTYRATE 1,3-DIISOPROPYLCYCLOHEXANE

Madecassoside, 98%, from Centella asiatica

MADECASSOIDE

MADECASSOSIDE

O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate

O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate

MADECASSOSIDE(P)

MADECASSOSIDE hplc

Asiaticoside A

glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)-

Urs-12-en-28-oicacid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-

2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid 6-O-[4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl ester

RederMic

MADECASSOSIDE WITH HPLC

Madecassoside, froM Centella asiatica

Madecassoside, 98%, from Centella asiatica (L.) Urb.

Madecassoside (Asiaticoside A)

Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)-

Madecassoside (8CI)

(1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate

34540-22-2

C48H78O20

Inhibitors

The group of Asiaticoside

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Saponins