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OLANEXIDINE

Product Name
OLANEXIDINE
CAS No.
146510-36-3
Chemical Name
OLANEXIDINE
Synonyms
OLANEXIDINE;Olanexidine-008;Olanexidine [inn];Olanexidine-008-HCl;Olanexidine Gluconate;Olanexidine Impurity 11;N1-(3,4-Dichlorobenzyl)-N5-octylbiguanide;N''-(3,4-dichlorobenzyl)-N'''-octylimidodicarbonimidic diamide;N''-(3,4-dichlorobenzyl)-N'''-octylimidodicarbonimidic diami...;1-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]-2-octylguanidine
CBNumber
CB42451253
Molecular Formula
C17H27Cl2N5
Formula Weight
372.34
MOL File
146510-36-3.mol
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OLANEXIDINE Property

Boiling point:
454.7±55.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
pka
11.92±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0019384
Product name
OLANEXIDINE
Purity
95.00%
Packaging
5MG
Price
$503.79
Updated
2021/12/16
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OLANEXIDINE Chemical Properties,Usage,Production

Description

In July 2015, olanexidine gluconate, a biguanide compound with remarkable antibacterial activity, was approved by the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan for skin antisepsis at surgical sites. The drug was developed and marketed by Otsuka Pharmaceutical in Japan and is available as topical solution (1.5%). Olanexidine gluconate exhibited efficacy against a wide range of bacterial strains, especially Grampositive bacteria. In vitro experiments exploring its mechanism of action indicated that olanexidine interacts with bacterial surface molecules (such as lipopolysaccharides and lipoteichoic acid), disrupting the cell membranes of liposomes. These models suggest that the drug permeates the membranes of both Escherichia coli and Staphylococcus aureus and denatures proteins at relatively high concentrations (>160 g/mL).

Definition

ChEBI: Olanexidine is a dichlorobenzene.

Synthesis

The synthesis of olanexidine gluconate is relatively straightforward, involving the linkage of an n-octyl side chain and a dichlorobenzylamine through a bis-guanidyl lynchpin. The synthesis began with the reaction of commercial noctylamine (17) with sodium dicyanamide in the presence of concentrated sulfuric acid in refluxing n-butyl acetate to give rise to 1-cyano-3-octylguanidine (18) in 86% yield . Conditions employed to subsequently secure biguanidine 20 as the HCl salt hemihydrate in 77% yield were nearly identical to those used for the conversion of 17 to 18. Finally, treatment of 20 with sodium hydroxide in the presence of gluconic acid (21) gave rise to olanexidin gluconate (II) in almost quantitative yield.

OLANEXIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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OLANEXIDINE Suppliers

Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4601
Advantage
55
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
10002
Advantage
58
Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd.
Tel
0531-58897130 15508676053
Email
drug_impurity@sdcclh.com
Country
China
ProdList
2007
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
Jinan blalong chemical co. LTD
Tel
2710913286@.com
Email
1513643261@qq.com
Country
China
ProdList
14246
Advantage
58
Guangzhou Juntang Technology Co., Ltd
Tel
020-36607679 13502246435
Email
sales@dmstandards.com
Country
China
ProdList
10945
Advantage
58
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View Lastest Price from OLANEXIDINE manufacturers

Career Henan Chemica Co
Product
OLANEXIDINE 146510-36-3
Price
US $17.00/g
Min. Order
1g
Purity
95%
Supply Ability
1KG
Release date
2020-10-28

146510-36-3, OLANEXIDINERelated Search:


  • N''-(3,4-dichlorobenzyl)-N'''-octylimidodicarbonimidic diamide
  • 1-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]-2-octylguanidine
  • Olanexidine Impurity 11
  • OLANEXIDINE
  • Imidodicarbonimidic diamide, N-((3,4-dichlorophenyl)methyl)-N'-octyl
  • Olanexidine [inn]
  • N-[(3,4-Dichlorophenyl)methyl]-N'-octylimidodicarbonimidic diamide
  • N1-(3,4-Dichlorobenzyl)-N5-octylbiguanide
  • Olanexidine Gluconate
  • Olanexidine-008-HCl
  • Olanexidine-008
  • N''-(3,4-dichlorobenzyl)-N'''-octylimidodicarbonimidic diami...
  • Imidodicarbonimidicdiamide,N-[(3,4-dichlorophenyl)methyl]-N'-octyl-
  • 146510-36-3
  • C17H27Cl2N5