TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE

Product Name: TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE
CAS No.: 99207-32-6
Chemical Name: TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE
Synonyms: 4-[Boc(methyl)amino]-1-butanol;N-Boc-4-(methylamino)butan-1-ol;TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE;tert-butyl N-(4-hydroxybutyl)-N-methylcarbamate;4-(N-tert-Butyloxycarbonyl-N-methylamino)butanol;(4-Hydroxy-butyl)-Methyl-carbaMic acid tert-butyl ester;Carbamic acid, (4-hydroxybutyl)methyl-, 1,1-dimethylethyl ester;Carbamic acid, N-(4-hydroxybutyl)-N-methyl-, 1,1-dimethylethyl ester
CBNumber: CB42453161
Molecular Formula: C10H21NO3
Formula Weight: 203.28
MOL File: 99207-32-6.mol

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TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE Property

storage temp.: 2-8°C
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: T205920
Product name: tert-Butyl4-Hydroxybutylmethylcarbamate
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR918265
Product name: tert-Butyl4-hydroxybutylmethylcarbamate
Purity: 96%
Packaging: 1g
Price: $198
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0379861
Product name: (4-HYDROXY-BUTYL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $505.63
Updated: 2021/12/16

AK Scientific

Product number: 4604AJ
Product name: tert-Butyl4-hydroxybutylmethylcarbamate
Packaging: 5g
Price: $601
Updated: 2021/12/16

Apolloscientific

Product number: OR918265
Product name: tert-Butyl4-hydroxybutylmethylcarbamate
Purity: 96%
Packaging: 5g
Price: $741
Updated: 2021/12/16

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TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE Chemical Properties,Usage,Production

Synthesis

42042-68-2

24424-99-5

99207-32-6

General procedure for the synthesis of N-Boc-N-methyl-4-aminomethylbutanol from 4-(methylamino)butan-1-ol and di-tert-butyl dicarbonate: a solution of 4-(methylamino)butan-1-ol (2.76g, 26.8mmol) in triethylamine/methanol (1:7 v/v, 100mL) was stirred for 10 minutes at 0 °C. Subsequently, a solution of di-tert-butyl dicarbonate (8.76 g, 40.2 mmol) in methanol (20 mL) was added dropwise over 10 min. The reaction mixture was stirred under nitrogen protection for 1 hour. After that, the temperature of the reaction system was allowed to gradually increase to room temperature and stirring was continued overnight. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in dichloromethane and washed with deionized water. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and concentrated to afford the colorless oily product N-Boc-N-methyl-4-aminomethylbutanol (4.54 g, 84% yield), which could be used in the next reaction without further purification.1H NMR (CDCl3) δ 3.66 (t, 2H), 3.23 (t, 2H), 2.83 (s, 3H), 1.78 (br s, 1H), 1.51-1.60 (m, 4H), 1.44 (s, 9H).

References

[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 14, p. 5819 - 5828
[2] Patent: WO2013/148230, 2013, A1. Location in patent: Page/Page column 30
[3] Tetrahedron Letters, 2006, vol. 47, # 43, p. 7551 - 7556
[4] Patent: US4975439, 1990, A

TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE Suppliers

China 44 India 1 United States 4 Global 49

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99207-32-6, TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATERelated Search:

BOC-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID N-BOC-ISONIPECOTIC ACID 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 4-Boc-1-Fmoc-2-Piperazine acetic acid 1-BOC-4-METHANESULFONYLOXYMETHYL-PIPERIDINE 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID 2-(N,N-DIMETHYLAMINOMETHYL)PHENYLBORONIC ACID N-BOC-4-ETHYL PIPERIDINECARBOXYLATE N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER 1-[(TERT-BUTYL)OXYCARBONYL]-4-(2-CHLOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID Boc-L-glutamic acid γ-benzyl ester N-carboxyanhydride trans-1-Boc-4-(4-chlorophenyl)-3-pyrrolidinecarboxylic acid BOC-N-ME-GLU(OBZL)-OH 1-[(TERT-BUTYL)OXYCARBONYL]-4-PHENYLPYRROLINE-3-CARBOXYLIC ACID 4-(4-METHOXY-PHENYL)-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER BOC-L-TRANSPRO(4-CH2OH) FMOC-D, L-ALA(3-PYRROLIDINYL-(2-N-BOC)) 1-[(TERT-BUTYL)OXYCARBONYL]-4-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLINE-3-CARBOXYLIC ACID

TERT-BUTYL 4-HYDROXYBUTYLMETHYLCARBAMATE

(4-Hydroxy-butyl)-Methyl-carbaMic acid tert-butyl ester

N-Boc-4-(methylamino)butan-1-ol

Carbamic acid, (4-hydroxybutyl)methyl-, 1,1-dimethylethyl ester

tert-butyl N-(4-hydroxybutyl)-N-methylcarbamate

4-(N-tert-Butyloxycarbonyl-N-methylamino)butanol

Carbamic acid, N-(4-hydroxybutyl)-N-methyl-, 1,1-dimethylethyl ester

4-[Boc(methyl)amino]-1-butanol

99207-32-6