4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

Product Name: 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
CAS No.: 183673-66-7
Chemical Name: 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
Synonyms: FMOC-PIP(BOC)-OH;Fmoc-L-Pip(Boc)-OH;1-BOC-4-FMOC-PIP-OH;FMOC-4,4-ACP(1-N-BOC);BOC-PIC(4)(4-NHBOC)-OH;1-N-Boc-4-N-Fmoc-Aminopiperi;1-BOC-4-N-FMOC-AMINO-PIPERIDINE;1-Boc-4-(Fmoc-amino)piperidine-4;1-N-BOC-4-N-FMOC-AMINO-4-CARBOXYLIC-PIPERIDINE;1-BOC-PIPERIDINE-4-FMOC-AMINO-4-CARBOXYLIC ACID
CBNumber: CB2673000
Molecular Formula: C26H30N2O6
Formula Weight: 466.53
MOL File: 183673-66-7.mol

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4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Property

Melting point:: 80-82 °C
Boiling point:: 569.36°C (rough estimate)
Density: 1.2464 (rough estimate)
refractive index: 1.5300 (estimate)
storage temp.: Inert atmosphere,2-8°C
pka: 3.80±0.20(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 183673-66-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B619250
Product name: N-Boc-amino-(4-N-Fmoc-piperidinyl)carboxylicAcid
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Apolloscientific

Product number: OR953106
Product name: 1-Boc-4-(Fmoc-amino)-4-piperidinecarboxylicacid
Purity: 97%
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18901
Product name: N-Boc-amino-(4-N-fmoc-piperidinyl)carboxylic acid
Packaging: 250mg
Price: $140
Updated: 2021/12/16

Apolloscientific

Product number: OR953106
Product name: 1-Boc-4-(Fmoc-amino)-4-piperidinecarboxylicacid
Purity: 97%
Packaging: 1g
Price: $176
Updated: 2021/12/16

AK Scientific

Product number: V1376
Product name: N-Fmoc-Amino-(4-N-Boc-piperidinyl)carboxylicacid
Packaging: 1g
Price: $178
Updated: 2021/12/16

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4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Chemical Properties,Usage,Production

Chemical Properties

N-Boc-amino-(4-N-Fmoc-piperidinyl)carboxylic Acid is white to cream crystalline powder or chunks

Uses

N-Boc-amino-(4-N-Fmoc-piperidinyl)carboxylic acid is used in the preparation of synthetic peptide amides as kappa opioid receptor agonists for treatment of pain, pruritis and inflammation associated w ith a variety of diseases.

Uses

Cyclic ?,?-disubstituted amino acid for the preparation of water-soluble highly helical peptides.

Synthesis

28920-43-6

183673-71-4

183673-66-7

The general procedure for the synthesis of 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid from methyl chloroformate-9-fluorenylmethyl and 4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid was as follows: 4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (5 g, 20.5 mmol) was dissolved in THF (300 mL), an aqueous solution of Na2CO3 (6.45 g, 61.5 mmol, 3.0 eq.) was added (64.5 mL) and cooled to 0 °C. A THF solution (30 mL) of methyl 9-fluorenyl chloroformate (5.3 g, 30.7 mmol, 1.5 eq.) was added slowly and dropwise. The reaction mixture was gradually warmed to 25 °C and stirring was continued for 12 hours. After completion of the reaction, the reaction solution was carefully acidified with 1 M HCl and the crude product was extracted three times with EtOAc. The organic layers were combined, dried with Na2SO4, concentrated and purified by combiflash column chromatography (eluent: 0 to 10% MeOH/DCM) to afford the target product 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid (4.02 g, 42% yield). The product was confirmed by 1H NMR, 13C NMR and HRMS characterization.

References

[1] Organic Syntheses, 2005, vol. 81, p. 213 - 224
[2] Patent: WO2015/184349, 2015, A2. Location in patent: Paragraph 0225-0226

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Suppliers

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View Lastest Price from 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 183673-66-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-03

183673-66-7, 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTERRelated Search:

N-BOC-ISONIPECOTIC ACID 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 1-Boc-4-Methylaminopiperidine FMOC-D-DAB(FMOC)-OH 1-Amino-1-cyclohexanecarboxylic acid FMOC-DAB(BOC)-OH 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde tert-Butyl N-(3-aminopropyl)-N-methylcarbamate N-Boc-4-piperidinemethanol Ethyl 4-hydroxypiperidine-1-carboxylate 4-Amino-1-Boc-piperidine 1-Boc-piperidine 1-BOC-4-METHYLPIPERIDINE Isopropyl 4-aminopiperidine-1-carboxylate FMOC-D-DAB-OH FMOC-DAB-OH HCL Propamocarb Fmoc-Aib-OH

1-(TERT-BUTOXYCARBONYL)-4-([(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO)PIPERIDINE-4-CARBOXYLIC ACID

1-(TERT-BUTOXYCARBONYL)-4-FLUORENYLMETHOXYCARBONYLAMINOPIPERIDINE-4-CARBOXYLIC ACID

1-N-BOC-4-N-FMOC-AMINO-4-CARBOXYLIC-PIPERIDINE

1-N-BOC-4-N-FMOC-AMINOPIPERIDINE-4-CARBOXYLIC ACID

1-BOC-4-FMOC-PIP-OH

1-BOC-4-(FMOC-AMINO)-PIPERIDINE-4-CARBOXYLIC ACID

1-BOC-PIPERIDINE-4-FMOC-AMINO-4-CARBOXYLIC ACID

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

4-(FMOC-AMINO)-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID

4-[[(9H-Fluoren-9-ylMethoxy)carbonyl]aMino]-1,4-piperidinedicarboxylic Acid 1-(1,1-DiMethylethyl) Ester

1-BOC-4-N-FMOC-AMINO-PIPERIDINE

1-Boc-4-(FMoc-aMino)-4-piperidinecarboxylic acid

BOC-PIC(4)(4-NHBOC)-OH

FMOC-4,4-ACP(1-N-BOC)

FMOC-4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID

FMOC-PIP(BOC)-OH

N-ALPHA,GAMMA-DI-T-BUTOXYCARBONYL-4-AMINO-4-PIPECOLIC ACID

N-BOC-4-N-FMOC-AMINO-4-PIPERIDINYLCARBOXYLIC ACID

N-BOC-4-(FMOC-AMINO)PIPERIDINE-4-CARBOXYLIC ACID

N-(9-FLUORENYLMETHOXYCARBONYL)-AMINO-(4-N-(TERT-BUTOXYCARBONYL)-PIPERIDINYL)CARBOXYLIC ACID

1-[(tert-butoxy)carbonyl]-4-[(9H-fluoren-9-ylMethoxy)carbonyl]piperidine-4-carboxylic acid

1-(tert-butoxycarbonyl)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-piperidinecarboxylic acid

N-FMOC-AMINO-(4-N-BOC-PIPERIDINYL) CARBOXYLIC ACID

4-(((9H-fluoren-9-yl)Methoxy)carbonylaMino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

4-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic aci

1-Boc-piperidine-4-Fmoc-amino-4-carboxylic acid≥ 97% (HPLC)

Fmoc-L-Pip(Boc)-OH

1-Boc-4-(N-Fmoc-amino)piperidine-4-carboxylic acid

1,4-Piperidinedicarboxylicacid,4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-,1-(1,1-dimethylethyl)ester(9CI)

1-Boc-piperidine-4-N-Fmoc-amino-4-carboxylicacid

N-FMOC-Amino-(4-N-BOC-piperidinyl)carboxylicacid,95%

1-N-Boc-4-N-Fmoc-Aminopiperi

4-N-Fmoc-amino-1-N-Bocpiperidine-4-carboxylic acid

1-(N-Boc)-4-(Fmoc-amino)-piperidine-4-carboxylic acid

4-(((9H-fluoren-9-yl)methoxy)carbonyl)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

4-(9H-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylicaci

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER USP/EP/BP

4-(9H-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid

1-Boc-4-(Fmoc-amino)piperidine-4

1-(1,1-Dimethylethyl) 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1,4-piperidinedicarboxylate

1-Boc-Pi'ceridine-4-Fmoc-amino-4-carboxylic acid

4-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester, 10 mM in DMSO

183673-66-7

83673-66-7

C26H30N2O6

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

Others

Heterocycles

Others

Peptide Synthesis

Unnatural Amino Acid Derivatives

FMOC

amino acids

Amino Acid Derivatives

Amino Acids & Derivatives