tert-Butyl N-(3-aminopropyl)-N-methylcarbamate

Product Name: tert-Butyl N-(3-aminopropyl)-N-methylcarbamate
CAS No.: 150349-36-3
Chemical Name: tert-Butyl N-(3-aminopropyl)-N-methylcarbamate
Synonyms: N-(3-Aminopropyl)-N-methylcarbamic acid tert-butyl ester citrate;BUTTPARK 90\06-20;BOC-N-ME-1,3-DIAMINOPROPANE;Boc-N-Me-1,3-diaminopropane·HCl;N-Boc-N-Methyl-1,3-diaMinopropane;3-(N-Boc-N-methylamino)propylamine;N1-BOC-N1-METHYL-1,3-PROPANEDIAMINE;1-N-BOC-1-N-METHYL-1,3-DIAMINOPROPANE;N-Boc-N-methyl-1,3-diaminopropane,95%;1-N-BOC-1-N-Methyl-1,3-DIAMINOPROPANE-HCl
CBNumber: CB5242948
Molecular Formula: C9H20N2O2
Formula Weight: 188.27
MOL File: 150349-36-3.mol

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tert-Butyl N-(3-aminopropyl)-N-methylcarbamate Property

Boiling point:: 254.6±19.0 °C(Predicted)
Density: 0.982±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 10.06±0.10(Predicted)
form: Liquid
color: Pale yellow
Water Solubility: Slightly soluble in water.
CAS DataBase Reference: 150349-36-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B807045
Product name: tert-Butyl3-Aminopropyl(methyl)Carbamate
Packaging: 10g
Price: $595
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50498
Product name: Boc-N-Me-1,3-diaminopropane
Packaging: 25g
Price: $625
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4151-1-04
Product name: N-Methylpropane-1,3-diamine, N-Boc protected
Packaging: 5G
Price: $349
Updated: 2021/12/16

AK Scientific

Product number: W3285
Product name: N-(3-Aminopropyl)-N-methylcarbamicacidtert-butylester
Packaging: 5g
Price: $374
Updated: 2021/12/16

Iris Biotech GmbH

Product number: BNN1004
Product name: Boc,Me-DAP*HCl
Packaging: 5G
Price: $472.5
Updated: 2021/12/16

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tert-Butyl N-(3-aminopropyl)-N-methylcarbamate Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, agrochemicals and dyestuff.

Synthesis

24424-99-5

6291-84-5

150349-36-3

GENERAL STEPS: Preparation Example 1 Synthesis of tert-butyl-N-(3-aminopropyl)-N-methylcarbamate (2). N-methyl-1,3-propanediamine (1) (3.26 g, 37.03 mmol) was dissolved in methanol (100 ml), and a 35% hydrochloric acid solution was slowly added at 0 °C, followed by stirring. The reaction solution was stirred at room temperature for 30 min, then cooled to -10 °C and di-tert-butyl dicarbonate (10.51 g, 48.14 mmol) was slowly added. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and alkalized with 10% aqueous sodium hydroxide solution. The alkalized solution was extracted with dichloromethane and the organic phase was dried with anhydrous magnesium sulfate. The dried organic phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent ratio: dichloromethane: methanol: ammonia = 100:9:1, v/v/v) to give tert-butyl N-(3-aminopropyl)-N-methylcarbamate (2). Yield: 3.03 g (43%).1H NMR (400 MHz, CDCl3) δ 3.29 (2H, br, -CH2-NH2), 2.83 (3H, s, -N-CH3), 2.69 (2H, t, J = 6Hz, -N-CH2-CH2-), 1.64 (2H, m, -CH2-CH2-CH2-). 1.46 (9H, s, (CH3)3C-O-CO-), 1.38 (2H, s, -CH2-CH2-NH2).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 3, p. 1073 - 1079
[2] Patent: US2017/81291, 2017, A1. Location in patent: Paragraph 0023; 0046; 0047; 0048
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 6, p. 1565 - 1570

tert-Butyl N-(3-aminopropyl)-N-methylcarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl N-(3-aminopropyl)-N-methylcarbamate Suppliers

China 129 Germany 4 India 1 United Kingdom 3 United States 20 Global 157

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Shanghai Boc Chemical Co.,Ltd

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View Lastest Price from tert-Butyl N-(3-aminopropyl)-N-methylcarbamate manufacturers

Shanghai Rlavie Technology Co ltd

Product: 3-(N-Boc-N-methylamino)propylamine 150349-36-3
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2021-11-22

Career Henan Chemical Co

Product: tert-Butyl N-(3-aminopropyl)-N-methylcarbamate 150349-36-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-13

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BUTTPARK 90\06-20

BOC-N-ME-1,3-DIAMINOPROPANE

N-(3-Aminopropyl)-N-methylcarbamic acid tert-butyl

Boc-N-Me-1,3-diaminopropane·HCl

N-(3-Aminopropyl)-N-methylcarbamic acid ert-butyl ester

tert-Butyl N-(3-aminopropyl)-N-methylcarbamate

N-(3-Aminopropyl)-N-methylcarbamic acid tert-butyl ester citrate

3-(N-Boc-N-methylamino)propylamine

3-(N-tert-Butoxycarbonyl-N-methylamino)propylamine

1-N-BOC-1-N-Methyl-1,3-DIAMINOPROPANE-HCl

N-Boc-N-Methyl-1,3-diaMinopropane

N-Methylpropane-1,3-diamine, N-BOC protected

tert-Butyl (3-aminoprop-1-yl)methylcarbamate, N-(tert-Butoxycarbonyl)-N-methylpropane-1,3-diamine

Carbamic acid, N-(3-aminopropyl)-N-methyl-, 1,1-dimethylethyl ester

N1-BOC-N1-METHYL-1,3-PROPANEDIAMINE

N-Boc-N-methyl-1,3-diaminopropane,95%

1,1-Dimethylethyl N-(3-aminopropyl)-N-methylcarbamate

150349-36-3

C9H21N2O2HCl