ChemicalBook > CAS DataBase List > 2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL-

2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL-

Product Name
2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL-
CAS No.
6314-12-1
Chemical Name
2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL-
Synonyms
NSC 40200;5-Bromo-4-chloro-6-methylpyrimidin-2-amine;5-Bromo-4-chloro-6-methyl-2-pyrimidinamine;2-Amino-5-bromo-4-chloro-6-methylpyrimidine;2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL-;2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL- ISO 9001：2015 REACH
CBNumber
CB42463593
Molecular Formula
C5H5BrClN3
Formula Weight
222.47
MOL File
6314-12-1.mol
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2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL- Property

Density 
1.815
storage temp. 
-20°C, sealed storage, away from moisture and light
Appearance
Off-white to light brown Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB144130
Product name
5-Bromo-4-chloro-6-methylpyrimidin-2-amine
Packaging
250mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144130
Product name
5-Bromo-4-chloro-6-methylpyrimidin-2-amine
Packaging
500mg
Price
$140
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0419559
Product name
5-BROMO-4-CHLORO-6-METHYLPYRIMIDIN-2-AMINE
Purity
95.00%
Packaging
250MG
Price
$229.95
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144130
Product name
5-Bromo-4-chloro-6-methylpyrimidin-2-amine
Packaging
1g
Price
$246
Updated
2021/12/16
Matrix Scientific
Product number
073829
Product name
5-Bromo-4-chloro-6-methylpyrimidin-2-amine
Purity
95+%
Packaging
250mg
Price
$324
Updated
2021/12/16
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2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL- Chemical Properties,Usage,Production

Synthesis

5600-21-5

6314-12-1

The general procedure for the synthesis of 5-bromo-4-chloro-6-methyl-2-pyrimidinamine from 2-amino-4-chloro-6-methylpyrimidine is as follows: Example 6: Synthesis of 5-bromo-4-chloro-6-methylpyrimidin-2-amine 1. To a solution of 2-amino-4-chloro-6-methylpyrimidine (5.00 g, 34.8 mmol) in dichloromethane (240 mL) was slowly added bromine (1.88 mL, 36.6 mmol). 2. The reaction mixture was stirred at room temperature for 1.5 hours to form a suspension. 3. After the reaction was complete, the reaction mixture was diluted with dichloromethane (1.3 L). 4. The organic phase was washed sequentially with saturated sodium bicarbonate solution (2 x 200 mL) and brine (200 mL). 5. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated to give 5-bromo-4-chloro-6-methylpyrimidin-2-amine (7.5 g, 97% yield). Product Characterization: LCMS (M + H): 223 1H NMR (400 MHz, chloroform-d) δ ppm: 2.54 (s, 3H), 5.10 (s, 2H)

References

[1] Patent: WO2008/32162, 2008, A1. Location in patent: Page/Page column 62-63
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 15, p. 5098 - 5103
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 17, p. 8082 - 8093
[4] Patent: US2018/215720, 2018, A1. Location in patent: Paragraph 0057; 0059; 0074
[5] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 3, p. 637 - 646

2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL- manufacturers

Dideu Industries Group Limited
Product
2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL- 6314-12-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-02

6314-12-1, 2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL-Related Search:

Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI) 2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL- 2-Amino-4-chloro-6-methylpyrimidine 2-Amino-4-methyl-5-bromopyrimidine 2-Amino-5-bromopyrimidine

  • 2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL-
  • 5-Bromo-4-chloro-6-methylpyrimidin-2-amine
  • 2-Amino-5-bromo-4-chloro-6-methylpyrimidine
  • 5-Bromo-4-chloro-6-methyl-2-pyrimidinamine
  • NSC 40200
  • 2-PYRIMIDINAMINE, 5-BROMO-4-CHLORO-6-METHYL- ISO 9001：2015 REACH
  • 6314-12-1
  • C5H5BrClN3