SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE

SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE Property

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

White to off-white Solid

Safety

HS Code 

2933399990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Spiro[3H-indole-3,4''-piperidin]-2(1H)-one Hydrochloride, can be used as high-affinity, selective σ ligands.

Synthesis

1'-(Benzyloxycarbonyl)spiro[3H-indole-3,4'-piperidin]-2(1H)-one (74.6 mg) was used as a raw material and dissolved in methanol (1.5 mL). 10% palladium/carbon catalyst (14 mg) was added and the reaction was stirred at room temperature under hydrogen atmosphere for 4 hours. Upon completion of the reaction, the insoluble material was removed by filtration. To the filtrate, 1N aqueous hydrochloric acid (0.33 mL) was added, followed by evaporation of the solvent under reduced pressure to afford spiro[indoline-3,4-piperidin]-2-one hydrochloride (51.7 mg) in 98% yield. The product was characterized by 1H-NMR (D2O): δ 2.11 (4H, m), 3.48 (2H, m), 3.72 (2H, m), 7.07 (1H, d, J = 8 Hz), 7.18 (1H, t, J = 8 Hz), 7.35 (1H, t, J = 8 Hz), 7.45 (1H, d, J = 8 Hz). Mass spectrometry (TSP) analysis showed: m/z 203 (MH+).

References

[1] Patent: US2003/171370, 2003, A1