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DGAT-1 inhibitor

Product Name
DGAT-1 inhibitor
CAS No.
959122-11-3
Chemical Name
DGAT-1 inhibitor
Synonyms
CS-121;A922500;DGAT-1 inhibitor;DGAT-1 Inhibitor 4a;DGAT-1 Inhibitor, A 922500;DGAT-1 inhibitor USP/EP/BP;A922500(DGAT-1 Inhibitor 4a);DGAT-1 Inhibitor A922500 A-922500;DGAT-1 INHIBITOR 4A; A-922500; A922500;Diacyl glycerolacyltransferase 1 inhibitor
CBNumber
CB42470944
Molecular Formula
C26H24N2O4
Formula Weight
428.48
MOL File
959122-11-3.mol
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DGAT-1 inhibitor Property

Density 
1.323
storage temp. 
-20°C
solubility 
≥21.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
Light yellow solid
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Safety

Hazard Codes 
T,N
Risk Statements 
25-36-50
Safety Statements 
26-45-61
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A1737
Product name
A922500
Packaging
1MG
Price
$57.5
Updated
2023/06/20
Sigma-Aldrich
Product number
A1737
Product name
A922500
Packaging
5MG
Price
$242
Updated
2023/06/20
Sigma-Aldrich
Product number
A1737
Product name
A922500
Packaging
10MG
Price
$413
Updated
2023/06/20
Sigma-Aldrich
Product number
252801
Product name
DGAT-1 Inhibitor, A 922500
Packaging
5mg
Price
$298
Updated
2022/05/15
Cayman Chemical
Product number
10012708
Product name
A-922500
Purity
≥95%
Packaging
1mg
Price
$38
Updated
2024/03/01
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DGAT-1 inhibitor Chemical Properties,Usage,Production

Uses

A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.

Definition

ChEBI: A 922500 is an aromatic ketone.

Biological Activity

Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC 50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active.

Biochem/physiol Actions

The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.

DGAT-1 inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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DGAT-1 inhibitor Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Wuhan TCASChem Technology Co., Ltd.
Tel
027-027-86697669 13986148687
Fax
86-027-86697669
Email
sales@tcaschem.com
Country
China
ProdList
3881
Advantage
55
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
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View Lastest Price from DGAT-1 inhibitor manufacturers

Career Henan Chemical Co
Product
(1R,2R)-2-[[4'-[[(Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid 959122-11-3
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

959122-11-3, DGAT-1 inhibitorRelated Search:


  • (1R,2R)-2-[[4'-[[(Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid
  • DGAT-1 inhibitor
  • Diacyl glycerolacyltransferase 1 inhibitor
  • A922500
  • A922500(DGAT-1 Inhibitor 4a)
  • enylureido)biphenyl(1R,2R)-2-(4'-(3-phcarbonyl)cyclopentanecarboxylic acid
  • DGAT-1 Inhibitor 4a
  • (1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)cyclopentanecarboxylic acid
  • Cyclopentanecarboxylic acid, 2-[[4'-[[(phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]-, (1R,2R)-
  • (1R,2R)-2-(4,-(3-phenylureido)-[1,1,-biphenyl]-4-carbonyl)cyclopentanecarboxylic acid
  • DGAT-1 Inhibitor, A 922500
  • CS-121
  • DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem
  • DGAT-1 INHIBITOR 4A; A-922500; A922500
  • DGAT-1 inhibitor USP/EP/BP
  • DGAT-1 Inhibitor A922500 A-922500
  • (1R,2R)-2-(4'-(3-Phenylureido)-[1,1'-biphenyl]-4-carbonyl)cyclopentanecarboxylic acid
  • 959122-11-3
  • Inhibitor
  • Inhibitors
  • APIs