DGAT-1 inhibitor
- Product Name
- DGAT-1 inhibitor
- CAS No.
- 959122-11-3
- Chemical Name
- DGAT-1 inhibitor
- Synonyms
- CS-121;A922500;DGAT-1 inhibitor;DGAT-1 Inhibitor 4a;DGAT-1 Inhibitor, A 922500;DGAT-1 inhibitor USP/EP/BP;A922500(DGAT-1 Inhibitor 4a);DGAT-1 Inhibitor A922500 A-922500;DGAT-1 INHIBITOR 4A; A-922500; A922500;Diacyl glycerolacyltransferase 1 inhibitor
- CBNumber
- CB42470944
- Molecular Formula
- C26H24N2O4
- Formula Weight
- 428.48
- MOL File
- 959122-11-3.mol
DGAT-1 inhibitor Property
- Density
- 1.323
- storage temp.
- -20°C
- solubility
- ≥21.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- Light yellow solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A1737
- Product name
- A922500
- Packaging
- 1MG
- Price
- $57.5
- Updated
- 2023/06/20
- Product number
- A1737
- Product name
- A922500
- Packaging
- 5MG
- Price
- $242
- Updated
- 2023/06/20
- Product number
- A1737
- Product name
- A922500
- Packaging
- 10MG
- Price
- $413
- Updated
- 2023/06/20
- Product number
- 252801
- Product name
- DGAT-1 Inhibitor, A 922500
- Packaging
- 5mg
- Price
- $298
- Updated
- 2022/05/15
- Product number
- 10012708
- Product name
- A-922500
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
DGAT-1 inhibitor Chemical Properties,Usage,Production
Uses
A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.
Definition
ChEBI: A 922500 is an aromatic ketone.
Biological Activity
Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC 50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active.
Biochem/physiol Actions
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.
DGAT-1 inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
DGAT-1 inhibitor Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from DGAT-1 inhibitor manufacturers
- Product
- (1R,2R)-2-[[4'-[[(Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid 959122-11-3
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09