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Artemether

Product Name
Artemether
CAS No.
71963-77-4
Chemical Name
Artemether
Synonyms
artMether;Artimether;ARTHEMETER;ArteMether (SM-224);SM-224;Gvither;ArteMos;ArtenaM;cgp56696;Artesian
CBNumber
CB4248286
Molecular Formula
C16H26O5
Formula Weight
298.37
MOL File
71963-77-4.mol
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Artemether Property

Melting point:
86-88°C
Boiling point:
359.79°C (rough estimate)
alpha 
D19.5 +171° (c = 2.59 in CHCl3)
Density 
1.0733 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
off-white to light brown
optical activity
[α]/D +155 to +175°, c = 0.5 in methanol
Merck 
14,815
InChI
InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
InChIKey
SXYIRMFQILZOAM-HVNFFKDJSA-N
SMILES
O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](OC)O4)O1
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
3
RTECS 
KD4165000
HS Code 
29329930
Hazardous Substances Data
71963-77-4(Hazardous Substances Data)
Toxicity
LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H242Heating may cause a fire

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P235Keep cool.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P370+P378In case of fire: Use … for extinction.

P410Protect from sunlight.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9361
Product name
Artemether
Purity
≥98% (HPLC)
Packaging
5mg
Price
$90.8
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR3423
Product name
Artemether
Purity
certified reference material, pharmaceutical secondary standard
Packaging
200MG
Price
$222
Updated
2024/03/01
Sigma-Aldrich
Product number
1042780
Product name
Artemether
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$261.6
Updated
2024/03/01
TCI Chemical
Product number
A2190
Product name
Artemether
Purity
>98.0%(HPLC)
Packaging
5g
Price
$80
Updated
2024/03/01
TCI Chemical
Product number
A2190
Product name
Artemether
Purity
>98.0%(HPLC)
Packaging
25g
Price
$237
Updated
2024/03/01
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Artemether Chemical Properties,Usage,Production

Description

Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.

Chemical Properties

White Solid

Uses

Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.

Uses

atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist

Uses

Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when

Definition

ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria.

General Description

Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant.

Biochem/physiol Actions

Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.

Safety Profile

Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.

target

Antifection

storage

Store at -20°C

Artemether Preparation Products And Raw materials

Raw materials

Preparation Products

Artemisinin
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Artemether Suppliers

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View Lastest Price from Artemether manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Artemether 71963-77-4
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-08-27
Hebei Junhua Import and Export Co., LTD
Product
Artemether 71963-77-4
Price
US $0.00/kg
Min. Order
1kg
Purity
97%
Supply Ability
1000
Release date
2025-02-24
Hebei Dangtong Import and export Co LTD
Product
Artemether 71963-77-4
Price
US $1308.00-1260.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-04-12

71963-77-4, ArtemetherRelated Search:

4-Methoxybenzylchloride p-Anisidine Anisole 3-Methoxybenzaldehyde 4-Methoxyphenylacetone p-Anisaldehyde 2-Methoxyethanol (Trifluoromethoxy)benzene 4-Methoxyphenylacetic acid Quercetin tert-Butyl hydroperoxide tert-Amyl hydroperoxide Arteether ARTEMETHER alpha-Artemether artemisitene ArteMether Tetrahydrofuran Acetate artesunate

  • methyl-dihydroartemisinine
  • [3r-(3r,5as,6s,8as,9r,10r,12s,12ar**)]-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin
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  • cgp56696
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  • ARTEMTHER
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  • Artemether [3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
  • Artemether 71963-77-4
  • ARTEMETHER PH. INT
  • 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR)-, (+)
  • (3R,5aα,8aα,12aR)-Decahydro-10β-methoxy-3,6α,9β-trimethyl-3,12α-epoxypyrano[4,3-j]-1,2-benzodioxepin
  • (3R,5aα,8aα,12aR)-Decahydro-10β-methoxy-3,6α,9β-trimethyl-3β,12α-epoxypyrano[4,3-j]-1,2-benzodioxepin
  • Dihydroartemisin methyl ether
  • SM-224
  • WR-254986
  • (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
  • dihydroqinghaosu methyl ether
  • Artemether (100 mg)
  • ArteMos
  • ArtenaM
  • 3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin,decahydro-10-methoxy-3,6,9-trim
  • 5a-beta,6-beta,8a-beta,9-alpha,12-beta,12ar)-(3-alph(+)-ethyl
  • artemisininelactolmethylether
  • Artemether&gt
  • 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-
  • (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Methoxy-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
  • Artemether CP2015
  • α-(N-Methyl-Benzylamino）-3-Hydroxyacetophenone Hydrochloride
  • (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
  • Artemether USP/EP/BP
  • Artemetherr
  • ArtemetherQ: What is Artemether Q: What is the CAS Number of Artemether Q: What is the storage condition of Artemether Q: What are the applications of Artemether
  • Artemether (1042780)
  • Artemether, ≥ 98.0%
  • (+)-Artemether
  • Artemether, 10 mM in DMSO
  • 71963-77-4
  • 963-77-4
  • C16H26O5
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Antimalarial
  • chemical reagent