GSK1070916

Product Name: GSK1070916
CAS No.: 942918-07-2
Chemical Name: GSK1070916
Synonyms: CS-364;GSK1070916;GSK-1070916A;GSK1070916 USP/EP/BP;GSK-1070916 (NMI-900);GSK1070916;GSK 1070916;GSK-1070916?( GSK-1070916A);GSK1070916;GSK-1070916;GSK 1070916;GSK1070916 (NMI900 or GSK1070916 A);GSK-1070916 GSK1070916 NMI-900 NMI900
CBNumber: CB42485003
Molecular Formula: C30H33N7O
Formula Weight: 507.63
MOL File: 942918-07-2.mol

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GSK1070916 Property

Density: 1.21
storage temp.: Store at -20°C
solubility: ≥25.4 mg/mL in DMSO
form: solid
pka: 13.17±0.40(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22953
Product name: GSK1070916
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 22953
Product name: GSK1070916
Purity: ≥98%
Packaging: 5mg
Price: $167
Updated: 2024/03/01

Cayman Chemical

Product number: 22953
Product name: GSK1070916
Purity: ≥98%
Packaging: 10mg
Price: $292
Updated: 2024/03/01

Cayman Chemical

Product number: 22953
Product name: GSK1070916
Purity: ≥98%
Packaging: 25mg
Price: $632
Updated: 2024/03/01

TRC

Product number: G797455
Product name: GSK1070916
Packaging: 5mg
Price: $125
Updated: 2021/12/16

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GSK1070916 Chemical Properties,Usage,Production

Uses

GSK 1070916 is a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models.

Definition

ChEBI: 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-3-pyrazolyl]phenyl]-1,1-dimethylurea is a member of pyrazoles and a ring assembly.

Biological Activity

gsk1070916 is a potent and selective inhibitor of aurora b/c kinase with ki values of 0.38nm and 1.5nm, respectively [1].gsk1070916 is a reversible atp-competitive inhibitor of aurora b and aurora c with ki values of 0.38nm and 1.5nm, respectively. the spa assay shows gsk1070916 has a good selectivity over aurora a. it inhibits aurora b with ic50 value of 5nm but 1259nm for aurora a. it is also reported that treatment of gsk1070916 suppresses cell proliferation in a549 human lung cancer cells with ec50 value of 7nm. moreover, both in vitro and in vivo assays demonstrate gsk1070916 can inhibit the phosphorylation of histone h3, which is a substrate of aurora b. gsk1070916 can also suppress tumor growth in mice with hl-60 tumor xenografts [1].

target

Aurora B

References

[1] adams nd, adams jl, burgess jl, chaudhari am, copeland ra, donatelli ca, drewry dh, fisher ke, hamajima t, hardwicke ma, huffman wf, koretke-brown kk, lai zv, mcdonald ob, nakamura h, newlander ka, oleykowski ca, parrish ca, patrick dr, plant r, sarpong ma, sasaki k, schmidt sj, silva dj, sutton d, tang j, thompson cs, tummino pj, wang jc, xiang h, yang j, dhanak d. discovery of gsk1070916, a potent and selective inhibitor of aurora b/c kinase. j med chem. 2010 may 27;53(10):3973-4001.

GSK1070916 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK1070916 Suppliers

China 88 United Kingdom 1 United States 17 Global 106

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942918-07-2, GSK1070916Related Search:

Enzastaurin (LY317615) ZM 447439 MK-5108 (VX-689) Alisertib (MLN8237) Veliparib Barasertib (AZD1152-HQPA)

N'-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea

GSK1070916

3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea

N'-[4-[4-[2-[3-[(DiMethylaMino)Methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl

GSK-1070916A

GSK1070916;GSK 1070916

CS-364

GSK1070916;GSK-1070916;GSK 1070916

Urea, N'-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethyl-

GSK1070916 USP/EP/BP

GSK1070916 (NMI900 or GSK1070916 A)

GSK-1070916 GSK1070916 NMI-900 NMI900

GSK-1070916?( GSK-1070916A)

GSK-1070916 (NMI-900)

942918-07-2

Inhibitors

Inhibitor