ChemicalBook > CAS DataBase List > N-6-Trifluoroacetyl-L-lysine

N-6-Trifluoroacetyl-L-lysine

Product Name
N-6-Trifluoroacetyl-L-lysine
CAS No.
10009-20-8
Chemical Name
N-6-Trifluoroacetyl-L-lysine
Synonyms
Ε-TFA-LYSINE;LYR(TFA)-TYR;LYS(TFA)-TYR;H-LYS(TFA)-OH;L-Lys(Tfa)-OH;LYSINE(TFA)-OH;H-LYS(CF3CO)-OH;EPSILON-TFA-LYSINE;n(epsilon)-trifluoro;Trifluoroacetyllysine
CBNumber
CB4249490
Molecular Formula
C8H13F3N2O3
Formula Weight
242.2
MOL File
10009-20-8.mol
More
Less

N-6-Trifluoroacetyl-L-lysine Property

Melting point:
258
Boiling point:
382.5±42.0 °C(Predicted)
Density 
1.4
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
2 M HCl: 10 mg/mL, clear, colorless
pka
2.51±0.24(Predicted)
form 
Solid
color 
Off-White
BRN 
2122429
InChI
InChI=1S/C8H13F3N2O3/c9-8(10,11)7(16)13-4-2-1-3-5(12)6(14)15/h5H,1-4,12H2,(H,13,16)(H,14,15)/t5-/m0/s1
InChIKey
PZZHRSVBHRVIMI-YFKPBYRVSA-N
SMILES
C(O)(=O)[C@H](CCCCNC(C(F)(F)F)=O)N
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
1
F 
10
HS Code 
29241990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
53604
Product name
Nε-Trifluoroacetyl-L-lysine
Purity
≥96.0% (TLC)
Packaging
5G
Price
$77.8
Updated
2025/07/31
Sigma-Aldrich
Product number
53604
Product name
Nε-Trifluoroacetyl-L-lysine
Purity
≥96.0% (TLC)
Packaging
25g
Price
$229
Updated
2023/06/20
TCI Chemical
Product number
T2815
Product name
Nε-Trifluoroacetyl-L-lysine
Purity
>98.0%(T)
Packaging
5g
Price
$21
Updated
2025/07/31
TCI Chemical
Product number
T2815
Product name
Nε-Trifluoroacetyl-L-lysine
Purity
>98.0%(T)
Packaging
25g
Price
$56
Updated
2025/07/31
TRC
Product number
T788500
Product name
N6-Trifluoroacetyl-L-lysine
Packaging
25g
Price
$85
Updated
2021/12/16
More
Less

N-6-Trifluoroacetyl-L-lysine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts.

Definition

ChEBI: An N6-acyl-L-lysine where the N6-acyl group is trifluoroacetyl.

Biological Activity

Nε-Trifluoroacetyl-L-lysine is an inhibitor of L-lysine cyclodeaminase.', 'Nε-Trifluoroacetyl-L-lysine may be used to create synthetic organic polypeptides useful for nonaqueous capillary electrophoresis (NACE).

Synthesis

383-63-1

657-27-2

10009-20-8

1. Sodium ethanolate solution was prepared by dissolving sodium metal (4.6 g, 0.2 mol) in 200 mL of anhydrous ethanol. 2. L-lysine hydrochloride (18.25 g, 0.1 mol) was slowly added to the above solution under stirring conditions. 3. The reaction mixture was stirred continuously for 1 hour, followed by filtration to remove the insoluble precipitate. 4. The filtrate was cooled in an ice bath and ethyl trifluoroacetate (21.3 g, 0.15 mol) was added slowly and dropwise with vigorous stirring. 5. The reaction mixture was gradually warmed to room temperature and stirring was continued for 2 hours. 6. Acetic acid (6 g, 0.1 mol) was added to neutralize the reaction system and the resulting precipitate was subsequently collected by filtration. 7. The precipitate was washed sequentially with ethanol and acetone and dried to give the target product trifluoroacetyl lysine. 8. Yield: 15 g (62% yield). 9. MALDI-TOF mass spectrometry (positive ion mode): m/z 242.455 ([M+H]+, relative abundance 67%).

References

[1] Russian Journal of Organic Chemistry, 2007, vol. 43, # 10, p. 1427 - 1431
[2] Patent: WO2009/114809, 2009, A1. Location in patent: Page/Page column 7
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 255 - 258

N-6-Trifluoroacetyl-L-lysine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-6-Trifluoroacetyl-L-lysine Suppliers

Canada 1 China 332 Europe 2 Germany 5 India 25 Japan 5 Norway 1 Slovakia 1 South Korea 1 Switzerland 2 United Kingdom 7 United States 40 Global 422
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Alfa Chemistry
Tel
+1-5166625404;
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
20405
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
High Performance Product Engineering LLC.,
Tel
--
Fax
--
Country
United States
ProdList
60
Advantage
58
Panslavia Chemicals
Tel
--
Fax
--
Country
United States
ProdList
121
Advantage
58
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Ring Specialty Chemicals Inc.
Tel
--
Fax
--
Email
info@ringchemicals.com
Country
United States
ProdList
888
Advantage
39
Kingchem Inc.
Tel
--
Fax
--
Email
s.wang@kingchem.com
Country
United States
ProdList
757
Advantage
60
Pure Chemistry Scientific Inc
Tel
--
Fax
--
Email
sales@purechems.com
Country
United States
ProdList
2321
Advantage
50
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Jupiter Bioscience Limited
Tel
--
Fax
--
Email
vksaipriya@jupiterbioscience.com
Country
United States
ProdList
247
Advantage
68
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
City Chemical LLC
Tel
--
Fax
--
Email
sales@citychemical.com
Country
United States
ProdList
6708
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
AB Chem Technologies, LLC
Tel
--
Fax
--
Email
sales@abchemtech.com
Country
United States
ProdList
1101
Advantage
46
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
CGeneTech, Inc.
Tel
--
Fax
--
Email
qyu@cgenetech.com
Country
United States
ProdList
959
Advantage
30
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Ennova MedChem Group Inc., formerly Arch Corporation
Tel
--
Fax
--
Email
sales@ennovamedchem.com
Country
United States
ProdList
1218
Advantage
42
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66
City Chemicals Corporation
Tel
--
Fax
--
Country
United States
ProdList
6460
Advantage
72
More
Less

View Lastest Price from N-6-Trifluoroacetyl-L-lysine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N-6-Trifluoroacetyl-L-lysine 10009-20-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08
airuikechemical co., ltd.
Product
n-6-trifluoroacetyl-l-lysine 10009-20-8
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-6-Trifluoroacetyl-L-lysine 10009-20-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

10009-20-8, N-6-Trifluoroacetyl-L-lysineRelated Search:

Trifluoroacetyl chloride BOC-TRP-N(OCH3)CH3 Sodium triacetoxyborohydride HEXAFLUOROACETYLACETONE Acetylacetone Triethyl acetyl citrate Poly-L-lysine N-ACETYL-L-TYROSINE ETHYL ESTER DL-Lysine acetylsalicylate L-Lysine 3,3-Dimethyl-2-oxobutyric acid H-Lys-OBzl·HCl·TosOH Ethyl 2,6-diaminohexanoate dihydrochloride 6-Azido-L-norleucine HCl H-Lys(Mtt)-OH H-Lys-Leu-Lys-OH N6-Cbz-L-Lysine benzyl ester hydrochloride Lysine(propionyl)- OH

  • H-LYS(TFA)-OH
  • H-LYS(CF3CO)-OH
  • EPSILON-TFA-LYSINE
  • LYSINE(TFA)-OH
  • N-EPSILON-TRIFLUOROACETYL-L-LYSINE
  • N6-TRIFLUOROACETYL-L-LYSINE
  • N6-Trrifluoroacetyl-L-lysine(for Lisinopril)
  • N6-Trifluoroacetyl-L-lysine 98%
  • INTERMEDIATE OF QUINAPRIL/N6-TRIFLUOROACETYL-L-LYSINE
  • N-6-TRIFLUORO ACETYL-L-LYSINE ( LISINOPRIL INTERMEDIATE )
  • N6-Trifluoroacetyl-L-lysine98%
  • N(6)-Trifluoracetyl-L-Lysin
  • Ε-TFA-LYSINE
  • N-ε-Trifluoroacetyl-L-lysine
  • N1-Trifluoroacetyl-L-Lysine
  • N6-Trifluoroaccety-L-lysine
  • N6-Trifluoroacetyl-L-lysine (for lisinopril)
  • (2S)-2-amino-6-(2,2,2-trifluoroacetamido)hexanoic acid
  • (2S)-2-amino-6-(trifluoroacetamido)hexanoic acid
  • (S)-2-aMino-6-(2,2,2-trifluoroacetaMido)hexanoic acid
  • n(epsilon)-trifluoro
  • N-E-TRIFLUOROACETYL-L-LYSINE
  • Trifluoroacetyllysine
  • LYR(TFA)-TYR
  • N6-Tryfluoro Acetyl-L-Lysine
  • N<sup>ε</sup>-Trifluoroacetyl-L-lysine
  • (S)-2-AMino-6-(2,2,2-trifluoro-acetylaMino)-hexanoic acid
  • LYS(TFA)-TYR
  • L-Lys(Tfa)-OH
  • Nε-Trifluoroacetyl-L-lysine≥ 99% (Assay)
  • ε-TFA-lysine H-Lys(Tfa)-OH
  • Lys(tfa)-OH / K(Tfa)
  • L-Lysine, N6-(2,2,2-trifluoroacetyl)-
  • N-6-Trifluoroacetyl-L-lysine USP/EP/BP
  • N-6-Trifluoroacetyl-L-Lysine extrapure, 98%
  • N6-(2,2,2-Trifluoroacetyl)-L-lysine
  • Nε-Trifluoroacetyl Lysine
  • <i>N</i><sub>ε</sub>-Trifluoroacetyl-<sc>L</sc>-lysine
  • (S)-2-Amino-6-(2,2,2-trifluoro-acetcarboxcarboxcarboxamido)-hexanoic acid
  • 10009-20-8
  • 10009-60-8
  • C8H13F3N2O3
  • C8H13N2O3F3
  • Specialty Synthesis
  • Lysine
  • Peptide Synthesis
  • Amino Acid Derivatives
  • Amino Acids & Derivatives, Metabolites & Impurities
  • Amino Acids & Derivatives
  • Metabolites & Impurities
  • amino acid
  • API intermediates
  • Chemical intermediate for LISINOPRIL
  • 10009-20-8