ChemicalBook > CAS DataBase List > 1H-1-Ethyl Candesartan Cilexetil

1H-1-Ethyl Candesartan Cilexetil

Product Name: 1H-1-Ethyl Candesartan Cilexetil
CAS No.: 914613-35-7
Chemical Name: 1H-1-Ethyl Candesartan Cilexetil
Synonyms: Candesartan EP Imp E;Candesartan Impurity 2;Candesartan EP Impurity-E;Candesartan Cilexetil impurity E;1H-1-Ethyl Candesartan Cilexetil;Candesartan Cilexetil EP IMpurity E;Candesartan Cilexetil Impurity 5(EP Impurity E);Candesartan Cilexetil Impurity 5(Candesartan Cilexetil EP Impurity E);2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-;Candesartan Cilexetil EP Impurity E (Candesartan Cilexetil N1-Ethyl Analog)
CBNumber: CB42508599
Molecular Formula: C35H38N6O6
Formula Weight: 638.71282
MOL File: 914613-35-7.mol

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1H-1-Ethyl Candesartan Cilexetil Property

Melting point:: 90-93°C
Boiling point:: 842.0±75.0 °C(Predicted)
Density: 1.32
storage temp.: Refrigerator
solubility: ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
pka: 3.95±0.10(Predicted)
InChIKey: HKUZPIFWPFYKBZ-UHFFFAOYSA-N
SMILES: C1(OCC)N(CC2=CC=C(C3=CC=CC=C3C3N(CC)N=NN=3)C=C2)C2=C(C(OC(OC(OC3CCCCC3)=O)C)=O)C=CC=C2N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17912
Product name: 1H-1-ethyl Candesartan Cilexetil
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 17912
Product name: 1H-1-ethyl Candesartan Cilexetil
Purity: ≥98%
Packaging: 5mg
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 17912
Product name: 1H-1-ethyl Candesartan Cilexetil
Purity: ≥98%
Packaging: 10mg
Price: $330
Updated: 2024/03/01

TRC

Product number: E900870
Product name: 1H-1-EthylCandesartanCilexetil
Packaging: 10mg
Price: $180
Updated: 2021/12/16

ApexBio Technology

Product number: C5023
Product name: 1H-1-ethylCandesartanCilexetil
Packaging: 10mg
Price: $374
Updated: 2021/12/16

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1H-1-Ethyl Candesartan Cilexetil Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Candesartan Cilexetil Impurity E (PHARMEUROPA).

Biological Activity

1h-1-ethyl candesartan cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin ii type 1 receptor (at1) antagonist.angiotensin ii is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including at1[1]. at1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. furthermore, at1 mediates the classical biological actions of angiotensin ii. also, at1 has seven helical transmembrane domains, which is the characteristic of the superfamily of g-protein-coupled receptors. carboxyl-terminal region structure of at1 plays important roles in receptor internalization, desensitization and phosphorylation [2].

References

[1]. otsuka, m. reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin ii type 1 receptor antagonist. thorax. 2004; 59(1): 31-38.
[2]. guo, d., sun, y., hamet, p., & inagami, t. the angiotensin ii type 1 receptor and receptor-associated proteins. cell research. 2001; 11(3): 165-180.

1H-1-Ethyl Candesartan Cilexetil Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-1-Ethyl Candesartan Cilexetil manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Candesartan Cilexetil EP Impurity E 914613-35-7
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-24

914613-35-7, 1H-1-Ethyl Candesartan CilexetilRelated Search:

3-Aminosalicylic acid O-Desetheyl Candesartan Ethyl Ester Trityl candesartan Candesartan O-Desethyl Candesartan Cilexetil 2,5-Dihydroxybenzoic acid Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate N-Trityl Candesartan Ethyl Ester Trityl candesartan cilexetil Candesartan Cilexetil Methoxy Analogue 2H-2-Ethyl Candesartan Cilexetil 2-Desethoxy-2-hydroxy-1H-1-Ethyl Candesartan Cilexetil Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] Candesartan Methyl Ester Desethyl Analog 5-(phenylazo)salicylic acid CV 15959 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil Candesartan Cilexetil Impurity 17

1H-1-Ethyl Candesartan Cilexetil

Candesartan Cilexetil impurity E

Candesartan Impurity 2

2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester

2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-

Candesartan Cilexetil EP IMpurity E

Candesartan Cilexetil Impurity 5(EP Impurity E)

Candesartan EP Imp E

1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(1-ethyltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate

1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester

Candesartan Cilexetil EP Impurity E (Candesartan Cilexetil N1-Ethyl Analog)

Candesartan Cilexetil EP Impurity EQ: What is Candesartan Cilexetil EP Impurity E Q: What is the CAS Number of Candesartan Cilexetil EP Impurity E Q: What is the storage condition of Candesartan Cilexetil EP Impurity E Q: What are the applications of Candesartan Cilexetil EP Impurity E

Candesartan Cilexetil,1H1ethyl Candesartan Cilexetil,Inhibitor,1H 1 ethyl Candesartan Cilexetil,inhibit

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1- ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7- carboxylate

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'- (1-ethyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)- 1H-benzo[d]imidazole-7-carboxylate

Candesartan EP Impurity-E

Candesartan Cilexetil Impurity 5(Candesartan Cilexetil EP Impurity E)

(1RS)-1-[[(Cyclohexyloxy)carbonyl]-oxy]ethyl 2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl

Candesartan Cilexetil Imp. E (EP): (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy- 1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate

1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2′-(1-ethyl-1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate

914613-35-7

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