2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product Name: 2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.: 83622-42-8
Chemical Name: 2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Synonyms: Pinacol (Chloromethyl)boronate;Chloromethylboronic acid pinal ester;chloroMethylboronic acid, pinacol ester;2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 2-(chloromethyl)-4,4,5,5-tetramethyl-;2-(2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;(Chloromethyl)boronic acid pinacol ester (may contain 5% (Bromomethyl)boronic acid pinacol ester)
CBNumber: CB42553115
Molecular Formula: C7H14BClO2
Formula Weight: 176.45
MOL File: 83622-42-8.mol

More

Less

2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Property

Boiling point:: 81℃ (14 Torr)
Density: 1.02±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
Appearance: Colorless to light yellow Liquid

More

Less

Safety

HS Code: 2931900090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

TRC

Product number: C427745
Product name: 2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Packaging: 250mg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-W006387
Product name: 2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Purity: ≥98.0%
Packaging: 5g
Price: $69
Updated: 2021/12/16

ChemScene

Product number: CS-W006387
Product name: 2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Purity: ≥98.0%
Packaging: 10g
Price: $135
Updated: 2021/12/16

AK Scientific

Product number: J53116
Product name: 2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Packaging: 10g
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143379
Product name: 2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Packaging: 500mg
Price: $165
Updated: 2021/12/16

More

Less

2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Chemical Properties,Usage,Production

Synthesis

76-09-5

83622-42-8

The general procedure for the synthesis of 2-(chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane from pinacol was as follows: to a mixed solution containing triisopropylborate (15 mL, 65 mmol), chloroiodomethane (13 g, 72 mmol), and tetrahydrofuran (78 mL) was added slowly and dropwise at -78 °C (external temperature) n-butyllithium ( 1.6 M hexane solution, 41 mL, 65 mmol) at -78 °C (external temperature), and the dropwise addition lasted for 20 min. After the dropwise addition, the reaction mixture was warmed to room temperature and stirred for 2.5 hours. Subsequently, the reaction mixture was cooled to 0 °C (external temperature) and a 4N hydrochloric acid-ethyl acetate solution was slowly added dropwise at this temperature until the reaction mixture reached neutrality. Pinacol (7.7 g, 65 mmol) was added to the reaction mixture while maintaining 0 °C, then the mixture was warmed to room temperature and stirred for 40 min. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the resulting residue was distilled under reduced pressure conditions (63-70 °C, 11 mmHg) to afford finally 2-(chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (9.2 g, 52 mmol, 81% yield). The product was characterized by 1H-NMR (CDCl3) with chemical shift δ (ppm) of 1.30 (12H, s), 2.97 (2H, s).

References

[1] Patent: US2008/15351, 2008, A1. Location in patent: Page/Page column 11

2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Suppliers

China 69 India 2 United Kingdom 2 United States 6 Global 79

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Shanghai ZaiQi Bio-Tech Co., Ltd.

Tel: 021-54824098, 021-37212705 021-37212706, 13391256916
Fax: 021-54824069
Email: sales@chemzq.com
Country: China
ProdList: 570
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Changzhou Chemscaler Pharmtech Co., Ltd.

Tel: 0519-81096292 15312577869
Email: chemscaler@yahoo.com.cn
Country: China
ProdList: 311
Advantage: 60

EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
ProdList: 1876
Advantage: 55

AllyChem Co., Ltd.

Tel: 0411-62313318 13942603642
Fax: 0411-87549748
Email: info@allychem.com
Country: China
ProdList: 1028
Advantage: 65

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

More

Less

View Lastest Price from 2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (Chloromethyl)boronic acid pinacol ester 83622-42-8
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-02

Career Henan Chemical Co

Product: 2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 83622-42-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-30

83622-42-8, 2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneRelated Search:

2-(4-chlorobenzyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane 4-Fluorobenzylboronic acid pinacol ester 3-Fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 4-BroMo-1-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 2-(2,5-Dibromo-3-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-CYCLOHEXENE-1-CARBOXYLIC ACID METHYL ESTER

(Chloromethyl)boronic acid pinacol ester (may contain 5% (Bromomethyl)boronic acid pinacol ester)

2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

chloroMethylboronic acid, pinacol ester

2-(2-(Chloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Pinacol (Chloromethyl)boronate

1,3,2-Dioxaborolane, 2-(chloromethyl)-4,4,5,5-tetramethyl-

Chloromethylboronic acid pinal ester

83622-42-8

C7H14BClO2

Organic boronic acid

organic boroinic acid