SC 66

Product Name: SC 66
CAS No.: 871361-88-5
Chemical Name: SC 66
Synonyms: SC 66;CS-2480;SC66;SC 66;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
CBNumber: CB42565930
Molecular Formula: C18H16N2O
Formula Weight: 276.33
MOL File: 871361-88-5.mol

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SC 66 Property

storage temp.: Sealed in dry,2-8°C
solubility: DMSO: ≥5mg/mL (warmed)
form: powder
color: faint yellow to dark yellow

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10876
Product name: SC-66
Purity: ≥98%
Packaging: 5mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 10876
Product name: SC-66
Purity: ≥98%
Packaging: 10mg
Price: $71
Updated: 2024/03/01

Cayman Chemical

Product number: 10876
Product name: SC-66
Purity: ≥98%
Packaging: 25mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 10876
Product name: SC-66
Purity: ≥98%
Packaging: 100mg
Price: $510
Updated: 2024/03/01

Tocris

Product number: 4398
Product name: SC66
Purity: ≥98%(HPLC)
Packaging: 50
Price: $378
Updated: 2021/12/16

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SC 66 Chemical Properties,Usage,Production

Description

Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP₃) or phosphatidylinositol-3,4-bisphosphate (PIP₂). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.

Uses

SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance.

storage

-20°C

SC 66 Preparation Products And Raw materials

Raw materials

Preparation Products

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SC 66 Suppliers

China 71 India 1 United Kingdom 1 United States 14 Global 87

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

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View Lastest Price from SC 66 manufacturers

Career Henan Chemical Co

Product: SC 66 871361-88-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

871361-88-5, SC 66Related Search:

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester SC-514 SC 57461A α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

SC 66

Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-

(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone

CS-2480

SC66;SC 66

(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone

Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis

871361-88-5